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Medicine

D-Index
80
Citations
19611
World Ranking
17279
National Ranking
1562

Overview

Derek A. Mann is affiliated with Newcastle University in the United Kingdom. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology. The scientist's publications reflect a focus on immunology, molecular biology, oncology, epidemiology, and cancer research.

The research topics covered by Derek A. Mann include:

  • Liver Disease Diagnosis and Treatment
  • Immune cells in cancer
  • Cancer Immunotherapy and Biomarkers
  • Liver physiology and pathology
  • Chemokine receptors and signaling
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Cancer Genomics and Diagnostics

Derek A. Mann's frequent co-authors are:

  • Jack Leslie
  • Fiona Oakley
  • Helen L. Reeves
  • Daniel Geh
  • Amy Collins

The scientist has published extensively in several venues, with the most frequent outlets being:

  • Journal of Hepatology (17 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (9 publications)
  • Nature (3 publications)
  • Nature Reviews Gastroenterology & Hepatology (3 publications)
  • Hepatology (3 publications)

Selected recent papers authored by Derek A. Mann include:

  • Apoptotic stress causes mtDNA release during senescence and drives the SASP, 2023, Nature
  • CXCR2 inhibition enables NASH-HCC immunotherapy, 2022, Gut
  • Neutrophils as potential therapeutic targets in hepatocellular carcinoma, 2022, Nature Reviews Gastroenterology & Hepatology
  • Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner, 2021, The EMBO Journal
  • Immunomodulatory Effects of Lenvatinib Plus Anti-Programmed Cell Death Protein 1 in Mice and Rationale for Patient Enrichment in Hepatocellular Carcinoma, 2021, Hepatology

Best Publications

  • Cellular senescence drives age-dependent hepatic steatosis.

    Mikolaj Ogrodnik;Satomi Miwa;Tamar Tchkonia;Dina Tiniakos;Dina Tiniakos

  • Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

    Diana Jurk;Caroline Wilson;Joao F. Passos;Fiona Oakley

  • Mitochondria are required for pro‐ageing features of the senescent phenotype

    Clara Correia-Melo;Clara Correia-Melo;Francisco D.M. Marques;Rhys Anderson;Graeme Hewitt

  • The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis

    AM Elsharkawy;F Oakley;DA Mann

  • Nuclear factor‐κB and the hepatic inflammation‐fibrosis‐cancer axis

    Ahmed M. Elsharkawy;Derek A. Mann

  • Clinical evidence for the regression of liver fibrosis

    Elizabeth L. Ellis;Derek A. Mann

  • Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats

    Matthew C. Wright;Razo Issa;David E. Smart;Nathan Trim

  • MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis.

    Jelena Mann;David C.K. Chu;Aidan Maxwell;Fiona Oakley

  • Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis

    Fiona Oakley;Muriel Meso;John P. Iredale;Karen Green

  • Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

    Mohsen Malehmir;Dominik Pfister;Suchira Gallage;Marta Szydlowska

  • Multigenerational epigenetic adaptation of the hepatic wound-healing response

    Müjdat Zeybel;Timothy Hardy;Yi K Wong;John C Mathers

  • Transcriptional regulation of hepatic stellate cell activation

    D A Mann;D E Smart

  • Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis

    J. Mann;F. Oakley;F. Akiboye;A. Elsharkawy

  • A molecular rheostat. Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression

    D A Mann;I Mikaélian;R W Zemmel;S M Green

  • Neurite outgrowth in response to transfected N-CAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMs

    Patrick Doherty;Lewis H. Rowett;Stephen E. Moore;Derek A. Mann

  • A Role for Serotonin (5-HT) in Hepatic Stellate Cell Function and Liver Fibrosis

    Richard G. Ruddell;Fiona Oakley;Ziafat Hussain;Irene Yeung

  • Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.

    Mohammad R Ebrahimkhani;Fiona Oakley;Lindsay B Murphy;Jelena Mann

  • Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

    Timothy Hardy;Mujdat Zeybel;Christopher P Day;Christian Dipper

  • Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis.

    Michael Jp Arthur;Derek A Mann;John P Iredale

  • Signal transduction via the NF-κB pathway: a targeted treatment modality for infection, inflammation and repair

    Shakir Ali;Derek A. Mann

Frequent Co-Authors

Fiona Oakley
Fiona Oakley Newcastle University
Alastair D. Burt
Alastair D. Burt Newcastle University
John P. Iredale
John P. Iredale University of Bristol
Hidekazu Tsukamoto
Hidekazu Tsukamoto University of Southern California
Quentin M. Anstee
Quentin M. Anstee Newcastle University
João F. Passos
João F. Passos Mayo Clinic
Paul A. Corris
Paul A. Corris Newcastle University
Christopher P. Day
Christopher P. Day Newcastle University
Sylvia Knapp
Sylvia Knapp Medical University of Vienna
Mark Harris
Mark Harris University of Leeds

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