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Biology and Biochemistry
UK
2023

D-Index & Metrics

Neuroscience

D-Index
93
Citations
30784
World Ranking
992
National Ranking
112

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2008 - Fellow of the Royal Society of Edinburgh
  • 1955 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Frank S. Walsh is affiliated with the Wolfson Centre for Age-Related Diseases in the United Kingdom. Their research primarily concentrates on medical and biochemical fields, with a significant focus on molecular biology and neuroscience. The scientist's body of work spans key aspects of medicine, biochemistry, genetics, molecular biology, and neuroscience.

The main topics covered in their research portfolio include monoclonal and polyclonal antibodies research, SARS-CoV-2 and COVID-19 research, nerve injury and regeneration, RNA and protein synthesis mechanisms, protein purification and stability, neuroscience, neuropharmacology research, and Alzheimer's disease research and treatments.

Frequently collaborating with other researchers, Frank S. Walsh has worked extensively with Paweł Stocki, J. Lynn Rutkowski, Aziz Gauhar, Mykhaylo Demydchuk, and Tanja Gerlza. These coauthors have contributed to multiple publications, reflecting ongoing research partnerships.

Frank S. Walsh's research has been published in several scientific journals, with the highest number of publications appearing in The FASEB Journal and Pharmaceutics. Other venues include bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, and the International Journal of Molecular Sciences.

Significant recent papers include:

  • Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1 (2020, The FASEB Journal)
  • Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle (2020, The FASEB Journal)
  • Single domain shark VNAR antibodies neutralize SARS-CoV-2 infection in vitro (2021, The FASEB Journal)
  • A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson's Disease (2022, Pharmaceutics)
  • CDR3 Variants of the TXB2 Shuttle with Increased TfR1 Association Rate and Enhanced Brain Penetration (2023, Pharmaceutics)

Their work spans various subfields including molecular biology, radiology, nuclear medicine and imaging, cellular and molecular neuroscience, infectious diseases, and physiology.

Frank S. Walsh has received several distinctions, such as being named a Fellow of the Royal Society of Edinburgh in 2008. Earlier, they were recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 1955. Additionally, they are a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Identification of a novel aspartic protease (Asp 2) as beta-secretase.

    Ishrut Hussain;David Powell;David R. Howlett;David G. Tew

  • A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration

    Gitali Mukhopadhyay;Patrick Doherty;Frank S. Walsh;Paul R. Crocker

  • Monoclonal antibody to a plasma membrane antigen of neurons

    George S. Eisenbarth;Frank S. Walsh;Marshall W. Nirenberg

  • Inhibitor of neurite outgrowth in humans.

    Rabinder Prinjha;Stephen E. Moore;Mary Vinson;Sian Blake

  • Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin

    Emma J. Williams;Josie Furness;Frank S. Walsh;Patrick Doherty

  • Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance.

    Frank S. Walsh;Patrick Doherty

  • Oligodendrocyte Population Dynamics and the Role of PDGF In Vivo

    Andrew R Calver;Anita C Hall;Wei-Ping Yu;Frank S Walsh

  • Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice

    Ying Gao;Dmitry V. Vasilyev;Maria Beatriz Goncalves;Fiona V. Howell

  • Neuropilin-2 Is Required In Vivo for Selective Axon Guidance Responses to Secreted Semaphorins

    Roman J. Giger;Jean François Cloutier;Amar Sahay;Rabinder K. Prinjha

  • Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels

    Patrick Doherty;Sandra V. Ashton;Stephen E. Moore;Frank S. Walsh

  • CAM-FGF Receptor Interactions: A Model for Axonal Growth

    Patrick Doherty;Frank S. Walsh

  • Role of myelin Po protein as a homophilic adhesion molecule

    Marie T. Filbin;Frank S. Walsh;Bruce D. Trapp;John A. Pizzey

  • Unified nomenclature for the semaphorins/collapsins [1]

    J. A. Bamberg;S. Baumgartner;H. Betz;J. Bolz

  • Expression of a Dominant Negative FGF Receptor Inhibits Axonal Growth and FGF Receptor Phosphorylation Stimulated by CAMs

    Jane L. Saffell;Emma J. Williams;Ivor J. Mason;Frank S. Walsh

  • Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival

    C. Jaillard;S. Harrison;B. Stankoff;M. S. Aigrot

  • Neurite outgrowth in response to transfected N-CAM changes during development and is modulated by polysialic acid.

    Patrick Doherty;James Cohen;Frank S. Walsh

  • Drug repositioning for Alzheimer's disease

    Anne Corbett;James Pickett;Alistair Burns;Jonathan Corcoran

  • Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules

    Patrick Doherty;Frank S. Walsh

  • A threshold effect of the major isoforms of NCAM on neurite outgrowth.

    Doherty P;Fruns M;Seaton P;Dickson G

  • Alternative splicing generates a secreted form of N-CAM in muscle and brain.

    Hilary J. Gower;C.Howard Barton;Vicki L. Elsom;Joanne Thompson

  • Neurite Outgrowth Stimulated by Neural Cell Adhesion Molecules Requires Growth-Associated Protein-43 (GAP-43) Function and Is Associated with GAP-43 Phosphorylation in Growth Cones

    Karina F. Meiri;Jane L. Saffell;Frank S. Walsh;Patrick Doherty

Frequent Co-Authors

Kay E. Davies
Kay E. Davies University of Oxford
Donald R. Love
Donald R. Love Auckland City Hospital
Elisabeth Bock
Elisabeth Bock University of Copenhagen
David P. Kelsell
David P. Kelsell Queen Mary University of London
Nigel K. Spurr
Nigel K. Spurr GlaxoSmithKline (United Kingdom)
Elizabeth M. C. Fisher
Elizabeth M. C. Fisher University College London
Helen M. Blau
Helen M. Blau Stanford University
Stephen J. Moss
Stephen J. Moss Tufts University
Alex L. Kolodkin
Alex L. Kolodkin Johns Hopkins University School of Medicine

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