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Per Eystein Lønning

Per Eystein Lønning

D-Index & Metrics

Medicine

D-Index
86
Citations
74263
World Ranking
13828
National Ranking
64

Overview

Per Eystein Lønning is affiliated with Haukeland University Hospital in Norway and has contributed to the fields of biochemistry, genetics, molecular biology, and medicine through numerous research publications. Their work spans several subfields including molecular biology, oncology, cancer research, genetics, and hepatology. The main research topics they engage with include epigenetics and DNA methylation, cancer genomics and diagnostics, PARP inhibition in cancer therapy, BRCA gene mutations in cancer, hepatocellular carcinoma treatment and prognosis, colorectal cancer treatments and studies, and DNA repair mechanisms.

The scientist's recent papers cover key subjects within oncology and molecular biology. Notable publications include:

  • Olaparib monotherapy as primary treatment in unselected triple negative breast cancer (2020, Annals of Oncology)
  • Anthracycline-containing and taxane-containing chemotherapy for early-stage operable breast cancer: a patient-level meta-analysis of 100,800 women from 86 randomised trials (2023, The Lancet)
  • Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade Serous Ovarian Cancer (2022, JAMA Oncology)
  • C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer (2022, Nature Communications)
  • Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers (2022, Clinical Cancer Research)

Frequent co-authors collaborating with Lønning include:

  • Stian Knappskog
  • Oleksii Nikolaienko
  • Hans Petter Eikesdal
  • Bjørnar Gilje
  • Egil Støre Blix

Their work has been published repeatedly in several scientific venues. These include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Oncology
  • Annals of Oncology
  • Clinical Epigenetics

Per Eystein Lønning's contributions involve research into key mechanisms underlying cancer biology such as DNA repair, epigenetic regulation, and responses to targeted therapies. Their median engagement in research topics related to PARP inhibition and BRCA gene mutations highlights a focus on personalized therapy approaches for breast and ovarian cancers.

Best Publications

  • Molecular portraits of human breast tumours

    Charles M. Perou;Therese Sørlie;Michael B. Eisen;Matt van de Rijn

  • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

    Therese Sørlie;Charles M. Perou;Robert Tibshirani;Turid Aas

  • Repeated observation of breast tumor subtypes in independent gene expression data sets

    Therese Sørlie;Robert Tibshirani;Joel Parker;Trevor Hastie

  • A Randomized Trial Of Exemestane After Two To Three Years Of Tamoxifen Therapy In Postmenopausal Women With Primary Breast Cancer.

    R. C Coombes;E. Hall;L. J. Gibson;R. Paridaens

  • Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

    Jonathan R. Pollack;Therese Sørlie;Charles M. Perou;Christian A. Rees

  • Survival and safety of exemestane versus tamoxifen after 2–3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial

    RC Coombes;LS Kilburn;CF Snowdon;R Paridaens

  • Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

    Turid Aas;Anne Lise Børresen;Stephanie Geisler;Birgitte Smith-Sørensen

  • Subclonal diversification of primary breast cancer revealed by multiregion sequencing

    Lucy R. Yates;Moritz Gerstung;Stian Knappskog;Christine Desmedt

  • Long-term Cultures of Bone Marrow–Derived Human Mesenchymal Stem Cells Frequently Undergo Spontaneous Malignant Transformation

    Gro Vatne Røsland;Agnete Svendsen;Anja Torsvik;Ewa Sobala

  • Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays

    Jonathan R. Pollack;Charles M. Perou;Therese Sorlie;Ash A. Alizadeh

  • Influence of Letrozole and Anastrozole on Total Body Aromatization and Plasma Estrogen Levels in Postmenopausal Breast Cancer Patients Evaluated in a Randomized, Cross-Over Study

    Jürgen Geisler;Ben Haynes;Gun Anker;Mitch Dowsett

  • Genomic Evolution of Breast Cancer Metastasis and Relapse

    Lucy R. Yates;Stian Knappskog;Stian Knappskog;David Wedge;David Wedge;James H.R. Farmery

  • Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer

    Anna Bergamaschi;Young H. Kim;Pei Wang;Pei Wang;Therese Sørlie

  • Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer.

    Stephanie Geisler;Per Eystein Lønning;Turid Aas;Hilde Johnsen

  • Activity of Exemestane in Metastatic Breast Cancer After Failure of Nonsteroidal Aromatase Inhibitors: A Phase II Trial

    Per Eystein Lønning;Emilio Bajetta;Robin Murray;Michèle Tubiana-Hulin

  • Buparlisib plus fulvestrant in postmenopausal women with hormone-receptor-positive, HER2-negative, advanced breast cancer progressing on or after mTOR inhibition (BELLE-3): a randomised, double-blind, placebo-controlled, phase 3 trial

    Angelo Di Leo;Stephen Johnston;Keun Seok Lee;Eva Ciruelos

  • Influence of anastrozole (Arimidex), a selective, non-steroidal aromatase inhibitor, on in vivo aromatisation and plasma oestrogen levels in postmenopausal women with breast cancer.

    J. Geisler;N. King;M. Dowsett;L. Ottestad

  • In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients

    J Geisler;N King;G Anker;G Ornati

  • Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on track - letter.

    Anja Torsvik;Gro V. Røsland;Agnete Svendsen;Anders Molven

  • Effects of Exemestane Administered for 2 Years Versus Placebo on Bone Mineral Density, Bone Biomarkers, and Plasma Lipids in Patients With Surgically Resected Early Breast Cancer

    Per E. Lønning;Jürgen Geisler;Lars E. Krag;Bjørn Erikstein

Frequent Co-Authors

Stian Knappskog
Stian Knappskog University of Bergen
Anne Lise Børresen-Dale
Anne Lise Børresen-Dale Oslo University Hospital
Johan R. Lillehaug
Johan R. Lillehaug University of Bergen
Mitch Dowsett
Mitch Dowsett Breast Cancer Research Foundation
Vessela N. Kristensen
Vessela N. Kristensen Oslo University Hospital
Lars A. Akslen
Lars A. Akslen University of Bergen
Per Magne Ueland
Per Magne Ueland University of Bergen
Lars J. Vatten
Lars J. Vatten Norwegian University of Science and Technology
Kristian Hveem
Kristian Hveem Norwegian University of Science and Technology
Pål Romundstad
Pål Romundstad Norwegian University of Science and Technology

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