World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
118
Citations
72650
World Ranking
3979
National Ranking
39

Overview

Christos Sotiriou is affiliated with the Université Libre de Bruxelles in Belgium. Their research activity spans primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. A significant focus lies in Oncology and Cancer Research, with expertise also extending to Molecular Biology, Pulmonary and Respiratory Medicine, and Radiology, Nuclear Medicine and Imaging.

The topics most frequently addressed in their work include Cancer Genomics and Diagnostics, Breast Cancer Treatment Studies, and Cancer Immunotherapy and Biomarkers. Other areas of research encompass HER2/EGFR in Cancer Research, Cancer Cells and Metastasis, Advanced Breast Cancer Therapies, and Genetic Factors in Colorectal Cancer.

Sotiriou's recent scholarly output includes papers published in high-impact venues. Some notable publications are:

  • "The 2019 World Health Organization classification of tumours of the breast", 2020, Histopathology
  • "Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis", 2020, Nature
  • "70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age", 2021, The Lancet Oncology
  • "HER2-Low Breast Cancer: Molecular Characteristics and Prognosis", 2021, Cancers
  • "The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group", 2021, npj Breast Cancer

The venues where Sotiriou frequently publishes reflect their core research interests. These include:

  • Cancer Research
  • npj Breast Cancer
  • Annals of Oncology
  • Clinical Cancer Research
  • Journal of Clinical Oncology

Collaborations form a significant part of Sotiriou's research network. Frequent co-authors include:

  • David Venet
  • Françoise Rothé
  • Denis Larsimont
  • Martine Piccart
  • Mattia Rediti

Best Publications

  • The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014

    R. Salgado;C. Denkert;S. Demaria;N. Sirtaine

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Breast cancer classification and prognosis based on gene expression profiles from a population-based study

    Christos Sotiriou;Soek-Ying Neo;Lisa M McShane;Edward L Korn

  • Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis

    Christos Sotiriou;Pratyaksha Wirapati;Sherene Loi;Adrian Harris

  • International network of cancer genome projects

    Thomas J. Hudson;Thomas J. Hudson;Warwick Anderson;Axel Aretz;Anna D. Barker

  • Landscape of somatic mutations in 560 breast cancer whole-genome sequences

    Serena Nik-Zainal;Serena Nik-Zainal;Helen Davies;Johan Staaf;Manasa Ramakrishna

  • Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group

    Mitch Dowsett;Torsten O. Nielsen;Roger A’Hern;John Bartlett

  • Gene-expression signatures in breast cancer.

    Christos Sotiriou;Lajos Pusztai

  • The landscape of cancer genes and mutational processes in breast cancer

    Philip J. Stephens;Patrick S. Tarpey;Helen Davies;Peter Van Loo;Peter Van Loo

  • 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

    Fatima Cardoso;Laura J. van’t Veer;Jan Bogaerts;Leen Slaets

  • Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer

    Marc Buyse;Sherene Loi;Laura van't Veer;Giuseppe Viale

  • Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial

    S. Loi;S. Loi;S. Michiels;S. Michiels;R. Salgado;N. Sirtaine

  • Prognostic and Predictive Value of Tumor-Infiltrating Lymphocytes in a Phase III Randomized Adjuvant Breast Cancer Trial in Node-Positive Breast Cancer Comparing the Addition of Docetaxel to Doxorubicin With Doxorubicin-Based Chemotherapy: BIG 02-98

    Sherene Loi;Nicolas Sirtaine;Fanny Piette;Roberto Salgado

  • Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients.

    E de Azambuja;F Cardoso;G de Castro;M Colozza

  • The Microarray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

    Leming Shi;Gregory Campbell;Wendell D. Jones;Fabien Campagne

  • Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy With or Without Carboplatin in Human Epidermal Growth Factor Receptor 2–Positive and Triple-Negative Primary Breast Cancers

    Carsten Denkert;Gunter von Minckwitz;Jan C. Brase;Bruno V. Sinn

  • CD4+ follicular helper T cell infiltration predicts breast cancer survival

    Chunyan Gu-Trantien;Sherene Loi;Soizic Garaud;Carole Equeter

  • Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series,

    Christine Desmedt;Fanny Piette;Sherene Loi;Yixin Wang

  • Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures

    Pratyaksha Wirapati;Christos Sotiriou;Susanne Kunkel;Pierre Farmer

  • Definition of Clinically Distinct Molecular Subtypes in Estrogen Receptor–Positive Breast Carcinomas Through Genomic Grade

    Sherene Loi;Benjamin Haibe-Kains;Christine Desmedt;Françoise Lallemand

Frequent Co-Authors

Sherene Loi
Sherene Loi Peter MacCallum Cancer Centre
Martine Piccart
Martine Piccart Université Libre de Bruxelles
Denis Larsimont
Denis Larsimont Université Libre de Bruxelles
Benjamin Haibe-Kains
Benjamin Haibe-Kains Princess Margaret Cancer Centre
Roberto Salgado
Roberto Salgado Peter MacCallum Cancer Centre
Stefan Michiels
Stefan Michiels University of Paris-Saclay
Fatima Cardoso
Fatima Cardoso Champalimaud Foundation
Evandro de Azambuja
Evandro de Azambuja Université Libre de Bruxelles
Karen Willard-Gallo
Karen Willard-Gallo Institut Jules Bordet

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