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Medicine

D-Index
77
Citations
28273
World Ranking
18287
National Ranking
232

Overview

Denis Larsimont is affiliated with the Université Libre de Bruxelles in Belgium. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on Oncology and Cancer Research. Additional subfields include Radiology, Nuclear Medicine and Imaging, Molecular Biology, and Pulmonary and Respiratory Medicine.

The main topics addressed in their work cover Cancer Genomics and Diagnostics, Breast Cancer Treatment Studies, Cancer Immunotherapy and Biomarkers, Radiomics and Machine Learning in Medical Imaging, Cancer Cells and Metastasis, Breast Lesions and Carcinomas, and Immunotherapy and Immune Responses.

Frequent venues where Larsimont's research is published include:

  • Cancer Research
  • European Journal of Surgical Oncology
  • Annals of Oncology
  • npj Breast Cancer
  • The Journal of Pathology

Notable recent papers authored or co-authored by Denis Larsimont include:

  • The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice, 2020, The Journal of Pathology
  • Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer, 2020, npj Breast Cancer
  • Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity, 2021, Journal of Clinical Investigation
  • Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells, 2020, Nature Communications
  • Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights, 2022, British Journal of Cancer

Denis Larsimont frequently collaborates with several co-authors, including Christos Sotiriou, Ligia Craciun, Françoise Rothé, David Venet, and Isabelle Veys. The frequency of collaboration with these co-authors ranges from 30 to over 50 joint works.

Best Publications

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis

    Christos Sotiriou;Pratyaksha Wirapati;Sherene Loi;Adrian Harris

  • Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients.

    E de Azambuja;F Cardoso;G de Castro;M Colozza

  • CD4+ follicular helper T cell infiltration predicts breast cancer survival

    Chunyan Gu-Trantien;Sherene Loi;Soizic Garaud;Carole Equeter

  • Identification of molecular apocrine breast tumours by microarray analysis

    Pierre Farmer;Herve Bonnefoi;Véronique Becette;Michele Tubiana-Hulin

  • Definition of Clinically Distinct Molecular Subtypes in Estrogen Receptor–Positive Breast Carcinomas Through Genomic Grade

    Sherene Loi;Benjamin Haibe-Kains;Christine Desmedt;Françoise Lallemand

  • Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes.

    Christine Desmedt;Benjamin Haibe-Kains;Pratyaksha Wirapati;Marc Buyse

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group Part 2 TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

    Shona Hendry;Roberto Salgado;Thomas Gevaert;Prudence A. Russell;Prudence A. Russell

  • Identification of molecular apocrine breast tumours by microarray analysis

    P Farmer;H Bonnefoi;V Becette;M Tubiana-Hulin

  • Subclonal diversification of primary breast cancer revealed by multiregion sequencing

    Lucy R. Yates;Moritz Gerstung;Stian Knappskog;Christine Desmedt

  • Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research

    Shona Hendry;Roberto Salgado;Thomas Gevaert;Prudence A. Russell;Prudence A. Russell

  • Relationship Between Quantitative Estrogen and Progesterone Receptor Expression and Human Epidermal Growth Factor Receptor 2 (HER-2) Status With Recurrence in the Arimidex, Tamoxifen, Alone or in Combination Trial

    Mitch Dowsett;Craig Allred;Jill Knox;Emma Quinn

  • High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smaller.

    Ana Maria Gonzalez-Angulo;Jennifer K Litton;Kristine R Broglio;Funda Meric-Bernstam

  • Chromogenic in Situ Hybridization: A Practical Alternative for Fluorescence in Situ Hybridization to Detect HER-2/neu Oncogene Amplification in Archival Breast Cancer Samples

    Minna Tanner;David Gancberg;Angelo Di Leo;Denis Larsimont

  • Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

    Y S Ju;L B Alexandrov;M Gerstung;I Martincorena

  • PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor–positive breast cancer

    Sherene Loi;Sherene Loi;Sherene Loi;Benjamin Haibe-Kains;Samira Majjaj;Francoise Lallemand

  • HER-2 Amplification and Topoisomerase IIα Gene Aberrations as Predictive Markers in Node-positive Breast Cancer Patients Randomly Treated Either with an Anthracycline-based Therapy or with Cyclophosphamide, Methotrexate, and 5-Fluorouracil

    Angelo Di Leo;David Gancberg;Denis Larsimont;Minna Tanner

  • Comparison of HER-2 status between primary breast cancer and corresponding distant metastatic sites

    D. Gancberg;A. Di Leo;F. Cardoso;G. Rouas

  • Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials

    Richard Gray;Rosie Bradley;Jeremy Braybrooke;Zulian Liu

Frequent Co-Authors

Christos Sotiriou
Christos Sotiriou Université Libre de Bruxelles
Martine Piccart
Martine Piccart Université Libre de Bruxelles
Roberto Salgado
Roberto Salgado Peter MacCallum Cancer Centre
Karen Willard-Gallo
Karen Willard-Gallo Institut Jules Bordet
Fatima Cardoso
Fatima Cardoso Champalimaud Foundation
Sherene Loi
Sherene Loi Peter MacCallum Cancer Centre
Marianne Paesmans
Marianne Paesmans Université Libre de Bruxelles
Stefan Michiels
Stefan Michiels University of Paris-Saclay
Benjamin Haibe-Kains
Benjamin Haibe-Kains Princess Margaret Cancer Centre

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