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Biology and Biochemistry

D-Index
60
Citations
11995
World Ranking
12030
National Ranking
383

Overview

Jianlin Lei is affiliated with Tsinghua University in China. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with a significant emphasis on Molecular Biology and Structural Biology. Additional areas of study include Cardiology and Cardiovascular Medicine, Infectious Diseases, and Physiology.

Their work covers a wide range of specialized topics such as RNA Research and Splicing, Nuclear Structure and Function, Advanced Electron Microscopy Techniques and Applications, RNA and protein synthesis mechanisms, Ion channel regulation and function, RNA modifications and cancer, and Cardiac electrophysiology and arrhythmias.

Jianlin Lei has published several papers in notable scientific journals. Recent papers include:

  • Molecular Architecture of the SARS-CoV-2 Virus (2020), published in Cell
  • Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates (2020), published in Cell
  • Structural basis of γ-secretase inhibition and modulation by small molecule drugs (2020), published in Cell
  • Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine (2021), published in Angewandte Chemie International Edition
  • Comparative structural analysis of human Na v 1.1 and Na v 1.5 reveals mutational hotspots for sodium channelopathies (2021), published in Proceedings of the National Academy of Sciences

Frequent coauthors in Jianlin Lei's publications include Chuangye Yan, Yigong Shi, Gaoxingyu Huang, Qiang Zhou, and Xuechen Zhu.

Their research findings are often published in high-impact venues. The most frequent publication outlets are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science
  • Cell Research
  • Cell
  • Proceedings of the National Academy of Sciences

Best Publications

  • Molecular Architecture of the SARS-CoV-2 Virus

    Hangping Yao;Yutong Song;Yong Chen;Nanping Wu

  • Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta 1.

    Xiaojing Pan;Zhangqiang Li;Qiang Zhou;Huaizong Shen

  • Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins.

    Huaizong Shen;Dongliang Liu;Kun Wu;Jianlin Lei

  • Automated acquisition of cryo-electron micrographs for single particle reconstruction on an FEI Tecnai electron microscope.

    Jianlin Lei;Joachim Frank;Joachim Frank;Joachim Frank

  • Structure of the Nav1.4-β1 complex from electric Eel

    Zhen Yan;Qiang Zhou;Lin Wang;Jianping Wu

  • Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imaging

    Cuiji Sun;Hui Yang;Yi Yuan;Xin Tian

  • Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex

    Renhong Yan;Xin Zhao;Jianlin Lei;Qiang Zhou

  • Visualization of the Hybrid State of tRNA Binding Promoted by Spontaneous Ratcheting of the Ribosome

    Xabier Agirrezabala;Jianlin Lei;Jianlin Lei;Julie L. Brunelle;Rodrigo F. Ortiz-Meoz

  • An Atomic Structure of the Human Spliceosome

    Xiaofeng Zhang;Chuangye Yan;Jing Hang;Lorenzo I. Finci

  • Structure of the Human Lipid Exporter ABCA1.

    Hongwu Qian;Xin Zhao;Pingping Cao;Jianlin Lei

  • Structural basis for the modulation of voltage-gated sodium channels by animal toxins

    Huaizong Shen;Zhangqiang Li;Yan Jiang;Xiaojing Pan

  • Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes

    Shan Wu;Beril Tutuncuoglu;Kaige Yan;Hailey Brown

  • Structure of the human PKD1-PKD2 complex.

    Qiang Su;Feizhuo Hu;Xiaofei Ge;Jianlin Lei

  • Molecular basis for pore blockade of human Na+channel Nav1.2 by the mu-conotoxin KIIIA.

    Xiaojing Pan;Zhangqiang Li;Xiaoshuang Huang;Gaoxingyu Huang

  • Recognition of the amyloid precursor protein by human gamma-secretase.

    Rui Zhou;Guanghui Yang;Xuefei Guo;Qiang Zhou

  • Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel

    Yanyu Zhao;Gaoxingyu Huang;Jianping Wu;Qiurong Wu

  • Structural basis for the recognition of Sonic Hedgehog by human Patched1

    Xin Gong;Hongwu Qian;Pingping Cao;Xin Zhao

  • Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.

    Nan Wang;Xin Jiang;Xin Jiang;Shuo Zhang;Angqi Zhu

  • Structural basis of Notch recognition by human gamma-secretase

    Guanghui Yang;Rui Zhou;Qiang Zhou;Qiang Zhou;Xuefei Guo

  • Structure of the human activated spliceosome in three conformational states.

    Xiaofeng Zhang;Chuangye Yan;Xiechao Zhan;Lijia Li

Frequent Co-Authors

Yigong Shi
Yigong Shi Westlake University
Nieng Yan
Nieng Yan Princeton University
Chuangye Yan
Chuangye Yan Tsinghua University
Hong-Wei Wang
Hong-Wei Wang Tsinghua University
Hailin Peng
Hailin Peng Peking University
Lanjuan Li
Lanjuan Li Zhejiang University
Max Crispin
Max Crispin University of Southampton
Xiyun Yan
Xiyun Yan Chinese Academy of Sciences
Tong Wu
Tong Wu Chinese Academy of Sciences
Guangwen Yang
Guangwen Yang Tsinghua University

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