World's Best Scientists 2026 revealed!
Chuangye Yan

Chuangye Yan

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
16342
World Ranking
8632
National Ranking
267

Overview

Chuangye Yan is affiliated with Tsinghua University in China and has a research portfolio primarily centered on biochemistry, genetics, and molecular biology, with over 100 publications in this field.

Their work focuses on several subfields including molecular biology, structural biology, cell biology, physiology, and cellular and molecular neuroscience.

Key research topics explored by Yan include:

  • RNA research and splicing
  • RNA and protein synthesis mechanisms
  • Nuclear structure and function
  • Advanced electron microscopy techniques and applications
  • Receptor mechanisms and signaling
  • RNA modifications and cancer
  • Alzheimer's disease research and treatments

Yan has contributed to several recent papers published in high-impact journals, such as:

  • Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates, 2020, Cell
  • Structural basis of γ-secretase inhibition and modulation by small molecule drugs, 2020, Cell
  • A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols, 2021, Science
  • Cryo-EM structure of the human mitochondrial translocase TIM22 complex, 2020, Cell Research
  • Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex, 2022, Science

Frequent co-authors collaborating with Yan include:

  • Jianlin Lei
  • Yigong Shi
  • Fang Kong
  • Angqi Zhu
  • Nieng Yan

The scientist's publications are often featured in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cell Research
  • Science
  • Cell

Best Publications

  • Crystal structure of the human glucose transporter GLUT1

    Dong Deng;Chao Xu;Pengcheng Sun;Jianping Wu

  • Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors

    Dong Deng;Chuangye Yan;Xiaojing Pan;Magdy M. Mahfouz

  • An atomic structure of human γ-secretase

    Xiao Chen Bai;Chuangye Yan;Guanghui Yang;Peilong Lu

  • Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

    Xu Zhang;Wenlin Ren;Paul DeCaen;Chuangye Yan

  • Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

    Linfeng Sun;Xin Zeng;Chuangye Yan;Xiuyun Sun

  • Structural insights into the mechanism of abscisic acid signaling by PYL proteins

    Ping Yin;He Fan;Qi Hao;Xiaoqiu Yuan

  • Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

    Zhen Yan;Xiao Chen Bai;Chuangye Yan;Jianping Wu

  • Structural basis of ultraviolet-B perception by UVR8

    Di Wu;Qi Hu;Zhen Yan;Wen Chen

  • Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

    Zehan Hu;Chuangye Yan;Peiyuan Liu;Zhiwei Huang

  • Molecular basis of ligand recognition and transport by glucose transporters

    Dong Deng;Pengcheng Sun;Chuangye Yan;Meng Ke

  • Three-dimensional structure of human γ-secretase

    Peilong Lu;Xiao Chen Bai;Dan Ma;Tian Xie

  • Structure of a yeast spliceosome at 3.6-angstrom resolution

    Chuangye Yan;Jing Hang;Ruixue Wan;Min Huang

  • Structural basis for the modular recognition of single-stranded RNA by PPR proteins

    Ping Yin;Quanxiu Li;Chuangye Yan;Ying Liu

  • Structure of the voltage-gated calcium channel Cav1.1 complex

    Jianping Wu;Zhen Yan;Zhangqiang Li;Chuangye Yan

  • The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins

    Qi Hao;Ping Yin;Wenqi Li;Li Wang

  • Structure of a yeast activated spliceosome at 3.5 Å resolution

    Chuangye Yan;Ruixue Wan;Rui Bai;Gaoxingyu Huang

  • An Atomic Structure of the Human Spliceosome

    Xiaofeng Zhang;Chuangye Yan;Jing Hang;Lorenzo I. Finci

  • Structural Basis of RIP1 Inhibition by Necrostatins.

    Tian Xie;Wei Peng;Yexing Liu;Chuangye Yan

  • DeepPicker: A deep learning approach for fully automated particle picking in cryo-EM.

    Feng Wang;Huichao Gong;Gaochao Liu;Meijing Li

  • Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol

    Ping Yin;He Fan;Qi Hao;Xiaoqiu Yuan

Frequent Co-Authors

Yigong Shi
Yigong Shi Westlake University
Nieng Yan
Nieng Yan Princeton University
Jianlin Lei
Jianlin Lei Tsinghua University
Jian-Kang Zhu
Jian-Kang Zhu Southern University of Science and Technology
Haiteng Deng
Haiteng Deng Tsinghua University
Magdy M. Mahfouz
Magdy M. Mahfouz King Abdullah University of Science and Technology
Masaki Yamamoto
Masaki Yamamoto University of Hyogo
Feng Wang
Feng Wang University of California, Berkeley
Xing Wang Deng
Xing Wang Deng Peking University
Xin Jiang
Xin Jiang University of Siegen

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