Nikola P. Pavletich

Research.com Recognitions

• 2015 - Member of the National Academy of Medicine (NAM)
• 2014 - Fellow of the American Academy of Arts and Sciences
• 2012 - Member of the National Academy of Sciences
• 2003 - Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center

Overview

Best Publications

• Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations

  Yunje Cho;Svetlana Gorina;Philip D. Jeffrey;Nikola P. Pavletich

  3269
  Citations

• Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.

  Paul H. Kussie;Svetlana Gorina;Vincent Marechal;Brian Elenbaas

  3035
  Citations

• Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.

  Michael S. Finnin;Jill R. Donigian;Alona Cohen;Victoria M. Richon

  2525
  Citations

• Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

  Michael Ohh;Cheol Won Park;Cheol Won Park;Mircea Ivan;Michael A. Hoffman

  1930
  Citations

• Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

  Philip D. Jeffrey;Alicia A. Russo;Kornelia Polyak;Emma Gibbs

  1911
  Citations

• Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

  Ning Zheng;Brenda A. Schulman;Brenda A. Schulman;Langzhou Song;Julie J. Miller

  1745
  Citations

• Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

  C E Stebbins;A A Russo;C Schneider;N Rosen

  1732
  Citations

• Crystal Structure of the PTEN Tumor Suppressor: Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association

  J.-O. Lee;Haijuan Yang;M.-M. Georgescu;A. Di Cristofano

  1338
  Citations

• Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.

  Charles E. Stebbins;William G. Kaelin;Nikola P. Pavletich

  1217
  Citations

• Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.

  Alicia A. Russo;Philip D. Jeffrey;Andrea K. Patten;Joan Massagué

  1212
  Citations

• mTOR kinase structure, mechanism and regulation

  Haijuan Yang;Derek G. Rudge;Joseph D. Koos;Bhamini Vaidialingam

  1192
  Citations

• Structure of a c-Cbl–UbcH7 Complex: RING Domain Function in Ubiquitin-Protein Ligases

  Ning Zheng;Ping Wang;Philip D. Jeffrey;Nikola P. Pavletich

  1081
  Citations

• Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.

  Yigong Shi;Yan-Fei Wang;Lata Jayaraman;Haijuan Yang

  994
  Citations

• Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors.

  Nikola P Pavletich

  976
  Citations

• Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

  Jung-Hyun Min;Haifeng Yang;Mircea Ivan;Frank Gertler

  956
  Citations

• Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.

  Zhucheng Chen;Haijuan Yang;Nikola P. Pavletich

  915
  Citations

• Ubiquitination regulates PTEN nuclear import and tumor suppression

  Lloyd C. Trotman;Xinjiang Wang;Andrea Alimonti;Zhenbang Chen

  885
  Citations

• BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

  Haijuan Yang;Philip D. Jeffrey;Julie Miller;Elspeth Kinnucan

  877
  Citations

• Structural basis of cyclin-dependent kinase activation by phosphorylation.

  Alicia A. Russo;Philip D. Jeffrey;Nikola P. Pavletich

  834
  Citations

• Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.

  Svetlana Gorina;Nikola P. Pavletich

  832
  Citations