World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
17259
World Ranking
9539
National Ranking
694

Overview

Lars-Oliver Klotz is affiliated with Friedrich Schiller University Jena in Germany. Their research encompasses multiple fields, primarily within biochemistry, genetics, and molecular biology, as well as nursing. Their work includes notable contributions to understanding molecular mechanisms related to aging and oxidative stress.

Their research focuses on several interconnected topics, including:

  • Selenium in Biological Systems
  • Trace Elements in Health
  • Sulfur Compounds in Biology
  • Genetics, Aging, and Longevity in Model Organisms
  • Genomics, phytochemicals, and oxidative stress
  • FOXO transcription factor regulation
  • Sirtuins and Resveratrol in Medicine

Klotz's frequent co-authors include:

  • Holger Steinbrenner
  • Thilo Magnus Philipp
  • Niklas Krafczyk
  • Anna P. Kipp
  • Karl Köhnlein

The scientist has published across several venues, with multiple papers appearing in:

  • Free Radical Biology and Medicine
  • Antioxidants
  • Redox Biology
  • Zeitschrift für Gerontologie und Geriatrie
  • IUBMB Life

Selected recent publications include:

  • FOXO transcription factors in antioxidant defense, 2021, IUBMB Life
  • SEMO-1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro-aging factor conferring selective stress resistance, 2022, BioFactors
  • Selenium-binding protein 1 (SELENBP1) is a copper-dependent thiol oxidase, 2023, Redox Biology
  • Selen und Zink: "Antioxidanzien" für ein gesundes Altern?, 2020, Zeitschrift für Gerontologie und Geriatrie
  • A coupled enzyme assay for detection of selenium-binding protein 1 (SELENBP1) methanethiol oxidase (MTO) activity in mature enterocytes, 2021, Redox Biology

The subfields of their research are diverse, with publications covering nutrition and dietetics, molecular biology, biochemistry, aging, and geriatrics and gerontology.

Best Publications

  • Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

    Karen D. McCullough;Jennifer L. Martindale;Lars-Oliver Klotz;Tak-Yee Aw

  • Reactive Oxygen Species (Ros-Induced) Ros Release: A New Phenomenon Accompanying Induction of the Mitochondrial Permeability Transition in Cardiac Myocytes

    Dmitry B. Zorov;Charles R. Filburn;Lars Oliver Klotz;Jay L. Zweier

  • Redox regulation of FoxO transcription factors

    Lars-Oliver Klotz;Cristina Sánchez-Ramos;Ignacio Prieto-Arroyo;Pavel Urbánek

  • Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations A NEW FUNCTION FOR SELENOPROTEINS AS PEROXYNITRITE REDUCTASE

    Helmut Sies;Victor S. Sharov;Lars-Oliver Klotz;Karlis Briviba

  • Cellular responses to nanoparticles: Target structures and mechanisms

    Klaus Unfried;Catrin Albrecht;Lars-Oliver Klotz;Anna Von Mikecz

  • Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation

    Ellen Fritsche;Claudia Schäfer;Christian Calles;Thorsten Bernsmann

  • Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress.

    Lars-Oliver Klotz;Klaus-Dietrich Kröncke;Darius P. Buchczyk;Helmut Sies

  • Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health.

    James P Kehrer;Lars-Oliver Klotz

  • Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy

    Akimichi Morita;Thomas Werfel;Helger Stege;Constanze Ahrens

  • TOXIC AND SIGNALING EFFECTS OF PHOTOCHEMICALLY OR CHEMICALLY GENERATED SINGLET OXYGEN IN BIOLOGICAL SYSTEMS

    Briviba K;Klotz Lo;Sies H

  • European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

    Javier Egea;Isabel Fabregat;Yves M Frapart;Pietro Ghezzi

  • Central Role of Ferrous/Ferric Iron in the Ultraviolet B Irradiation-mediated Signaling Pathway Leading to Increased Interstitial Collagenase (Matrix-degrading Metalloprotease (MMP)-1) and Stromelysin-1 (MMP-3) mRNA Levels in Cultured Human Dermal Fibroblasts

    Peter Brenneisen;Jutta Wenk;L. Oliver Klotz;Meinhard Wlaschek

  • Selenoproteins: Antioxidant selenoenzymes and beyond

    Holger Steinbrenner;Bodo Speckmann;Lars-Oliver Klotz

  • Mitogen-activated protein kinase (p38-, JNK-, ERK-) activation pattern induced by extracellular and intracellular singlet oxygen and UVA

    Lars-Oliver Klotz;Corinne Pellieux;Karlis Briviba;Christel Pierlot

  • 1,4-naphthoquinones: from oxidative damage to cellular and inter-cellular signaling.

    Lars-Oliver Klotz;Xiaoqing Hou;Claus Jacob

  • Singlet oxygen-induced signaling effects in mammalian cells

    Lars-Oliver Klotz;Klaus-Dietrich Kröncke;Helmut Sies

  • Defenses against peroxynitrite: selenocompounds and flavonoids.

    Lars-Oliver Klotz;Helmut Sies

  • Role of myoglobin in the antioxidant defense of the heart.

    Ulrich Flögel;Axel Gödecke;Lars-Oliver Klotz;Jürgen Schrader

  • Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase.

    Tankred Schewe;Christian Sadik;Lars-Oliver Klotz;Tanihiro Yoshimoto

  • Copper Ions Strongly Activate the Phosphoinositide-3-Kinase/Akt Pathway Independent of the Generation of Reactive Oxygen Species

    Elena A. Ostrakhovitch;Mohammad Reza Lordnejad;Freimut Schliess;Helmut Sies

Frequent Co-Authors

Helmut Sies
Helmut Sies Heinrich Heine University Düsseldorf
Karlis Briviba
Karlis Briviba Heinrich Heine University Düsseldorf
Tilman Grune
Tilman Grune University of Potsdam
Kotb Abdelmohsen
Kotb Abdelmohsen National Institutes of Health
Jean Krutmann
Jean Krutmann Heinrich Heine University Düsseldorf
Nikki J. Holbrook
Nikki J. Holbrook Yale University
Antonio Miranda-Vizuete
Antonio Miranda-Vizuete Spanish National Research Council
Freimut Schliess
Freimut Schliess Heinrich Heine University Düsseldorf
James P. Kehrer
James P. Kehrer University of Alberta
Wilhelm Stahl
Wilhelm Stahl Heinrich Heine University Düsseldorf

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