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Biology and Biochemistry

D-Index
98
Citations
32212
World Ranking
1682
National Ranking
936

Overview

Brian O'Rourke is affiliated with Johns Hopkins University in the United States. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with notable specialization in molecular biology, cardiology and cardiovascular medicine, pathology and forensic medicine, physiology, and surgery.

The main topics of Brian O'Rourke's work include mitochondrial function and pathology, cardiac ischemia and reperfusion, mesenchymal stem cell research, tissue engineering and regenerative medicine, adipose tissue and metabolism, cardiovascular function and risk factors, and cardiac electrophysiology and arrhythmias.

Frequent publication venues for their work include Circulation Research, bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, Journal of Molecular and Cellular Cardiology, and Journal of Biological Chemistry.

Notable recent papers by Brian O'Rourke are as follows:

  • ATM-CHK 2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress, 2020, The EMBO Journal
  • Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs, 2020, Genome Medicine
  • Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease, 2021, Genome Research
  • MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca 2+ Leak, 2021, Circulation Research
  • Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy, 2021, Science Translational Medicine

Frequent coauthors collaborating with Brian O'Rourke include Deepthi Ashok, Ting Liu, Kyriakos N. Papanicolaou, D. Brian Foster, and Rita N. Bárcia.

Best Publications

  • Mitochondrial ATP-Dependent Potassium Channels Novel Effectors of Cardioprotection?

    Yongge Liu;Toshiaki Sato;Brian O’Rourke;Eduardo Marban

  • Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.

    Lili A. Barouch;Robert W. Harrison;Michael W. Skaf;Gisele O. Rosas

  • Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, II Model Studies

    Raimond L. Winslow;Jeremy Rice;Saleet Jafri;Eduardo Marbán

  • Sudden Cardiac Death Prediction and Prevention: Report From a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop

    Glenn I. Fishman;Sumeet S. Chugh;John P. Dimarco;Christine M. Albert

  • Ionic Mechanism of Action Potential Prolongation in Ventricular Myocytes From Dogs With Pacing-Induced Heart Failure

    Stefan Kääb;H. Bradley Nuss;Nipavan Chiamvimonvat;Brian O'Rourke

  • Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane.

    Wenhong Xu;Yongge Liu;Sheng Wang;Todd McDonald

  • Synchronized Whole Cell Oscillations in Mitochondrial Metabolism Triggered by a Local Release of Reactive Oxygen Species in Cardiac Myocytes

    Miguel A. Aon;Sonia Cortassa;Eduardo Marbán;Brian O'Rourke

  • Evidence for Mitochondrial K+ Channels and Their Role in Cardioprotection

    Brian O’Rourke

  • Mitochondrial ATP-Sensitive Potassium Channels Attenuate Matrix Ca2+ Overload During Simulated Ischemia and Reperfusion: Possible Mechanism of Cardioprotection

    Mitsushige Murata;Masaharu Akao;Brian O'Rourke;Eduardo Marbán

  • Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor

    Kenji Matsushita;Craig N Morrell;Beatrice Cambien;Shui Xiang Yang

  • Myocardial KATP Channels in Preconditioning

    Brian O’Rourke

  • An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics

    Sonia Cortassa;Miguel A. Aon;Eduardo Marbán;Raimond L. Winslow

  • ACTIVATION OF MITOCHONDRIAL ATP-DEPENDENT POTASSIUM CHANNELS BY NITRIC OXIDE

    Norihito Sasaki;Toshiaki Sato;Andreas Ohler;Brian O’Rourke

  • Modulation of Mitochondrial ATP-Dependent K+ Channels by Protein Kinase C

    Toshiaki Sato;Brian O’Rourke;Eduardo Marbán

  • Elevated Cytosolic Na+ Decreases Mitochondrial Ca2+ Uptake During Excitation-Contraction Coupling and Impairs Energetic Adaptation in Cardiac Myocytes

    Christoph Maack;Sonia Cortassa;Miguel A. Aon;Anand N. Ganesan

  • Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells

    Masaharu Akao;Andreas Ohler;Andreas Ohler;Brian O’Rourke;Eduardo Marbán

  • Mitochondrial Ion Channels

    Brian O’Rourke

  • Redox-optimized ROS balance: A unifying hypothesis

    M.A. Aon;S. Cortassa;B. O'Rourke

  • Oscillations of membrane current and excitability driven by metabolic oscillations in heart cells

    Brian O'Rourke;Brian M. Ramza;Eduardo Marban

  • The mitochondrial origin of postischemic arrhythmias

    Fadi G. Akar;Miguel A. Aon;Gordon F. Tomaselli;Brian O’Rourke

Frequent Co-Authors

Miguel A. Aon
Miguel A. Aon National Institutes of Health
Sonia Cortassa
Sonia Cortassa National Institutes of Health
Eduardo Marbán
Eduardo Marbán Cedars-Sinai Medical Center
David A. Kass
David A. Kass Johns Hopkins University School of Medicine
Gordon F. Tomaselli
Gordon F. Tomaselli Johns Hopkins University
Jennifer E. Van Eyk
Jennifer E. Van Eyk Cedars-Sinai Medical Center
Robert N. Cole
Robert N. Cole Johns Hopkins University School of Medicine
Charles Steenbergen
Charles Steenbergen Johns Hopkins University
Nona Sotoodehnia
Nona Sotoodehnia University of Washington
Nathan Pankratz
Nathan Pankratz University of Minnesota

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