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Neuroscience

D-Index
54
Citations
11263
World Ranking
4902
National Ranking
152

Overview

Toshiki Uchihara is affiliated with the Tokyo Metropolitan Institute of Medical Science in Japan. Their research spans multiple domains within medicine, biochemistry, genetics, molecular biology, and neuroscience, with a core focus on neurology and molecular biology applied to neurodegenerative disorders.

The scientist's primary fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Further emphasis is apparent in several subfields relevant to neurodegenerative research:

  • Neurology
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Physiology
  • Pulmonary and Respiratory Medicine

Their main research topics cover:

  • Parkinson's Disease Mechanisms and Treatments
  • Genetic Neurodegenerative Diseases
  • Alzheimer's Disease Research and Treatments
  • Neurological Disorders and Treatments
  • Amyotrophic Lateral Sclerosis Research
  • Mitochondrial Function and Pathology
  • Neurological Diseases and Metabolism

Toshiki Uchihara has published several notable scientific papers, including:

  • Neurofibrillary changes undergoing morphological and biochemical changes - How does tau with the profile shift of from four repeat to three repeat spread in Alzheimer brain?, 2020, Neuropathology
  • Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS, 2021, Nature Biotechnology
  • The Evolution-Driven Signature of Parkinson's Disease, 2020, Trends in Neurosciences
  • Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome, 2023, Brain Communications
  • Essential roles of plexin-B3+ oligodendrocyte precursor cells in the pathogenesis of Alzheimer's disease, 2021, Communications Biology

The scientist frequently publishes in venues such as:

  • Neuropathology
  • Acta Neuropathologica Communications
  • Communications Biology
  • BMC Neurology
  • Journal of the Neurological Sciences

Collaborations form a key part of their work. Frequent co-authors include:

  • Shuta Toru
  • Takanori Yokota
  • Katsuiku Hirokawa
  • Masato Hasegawa
  • Mari Yoshida

Best Publications

  • SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

    Koichiro Nakamura;Seon-Yong Jeong;Toshiki Uchihara;Midori Anno

  • Axonal α-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

    Satoshi Orimo;Toshiki Uchihara;Ayako Nakamura;Fumiaki Mori

  • Delayed-onset ataxia in mice lacking α-tocopherol transfer protein: Model for neuronal degeneration caused by chronic oxidative stress

    Takanori Yokota;Keiji Igarashi;Toshiki Uchihara;Kou Ichi Jishage

  • Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease.

    Satoshi Orimo;Takeshi Amino;Yoshinori Itoh;Atsushi Takahashi

  • Degeneration of Cardiac Sympathetic Nerve Begins in the Early Disease Process of Parkinson’s Disease

    Satoshi Orimo;Atsushi Takahashi;Toshiki Uchihara;Fumiaki Mori

  • PART is part of Alzheimer disease.

    Charles Duyckaerts;Heiko Braak;Jean Pierre Brion;Luc Buée

  • Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.

    Toshiki Uchihara;Benoit I. Giasson

  • Profound Cardiac Sympathetic Denervation Occurs in Parkinson Disease

    Takeshi Amino;Satoshi Orimo;Yoshinori Itoh;Atsushi Takahashi

  • Silver diagnosis in neuropathology: principles, practice and revised interpretation

    Toshiki Uchihara

  • Modeling the relation between neurofibrillary tangles and intellectual status.

    C Duyckaerts;M Bennecib;Y Grignon;T Uchihara

  • Vascular and parenchymal Aβ deposition in the aging dog: correlation with behavior

    M.-A Colle;M.-A Colle;J.-J Hauw;F Crespeau;T Uchihara

  • Enhanced expression of aquaporin 4 in human brain with infarction

    Kazuko Aoki;Toshiki Uchihara;Kuniaki Tsuchiya;Ayako Nakamura

  • Neuronal intranuclear inclusions in spinocerebellar ataxia type 2: triple-labeling immunofluorescent study

    Shigeru Koyano;Toshiki Uchihara;Hiroto Fujigasaki;Ayako Nakamura

  • Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy

    Satoshi Orimo;Toshiro Kanazawa;Ayako Nakamura;Toshiki Uchihara

  • 14-3-3 proteins and zeta isoform containing neurofibrillary tangles in patients with Alzheimer's disease.

    Takahiko Umahara;Toshiki Uchihara;Kuniaki Tsuchiya;Ayako Nakamura

  • Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylase

    Kazuyuki Ishida;Hiroshi Mitoma;Si‐Young Song;Toshiki Uchihara

  • Spinocerebellar Ataxia Type 6 Mutation Alters P-type Calcium Channel Function

    Shuta Toru;Takayuki Murakoshi;Kinya Ishikawa;Hironao Saegusa

  • Increased Expression of Neuronal Apolipoprotein E in Human Brain With Cerebral Infarction

    Kazuko Aoki;Toshiki Uchihara;Nobuo Sanjo;Ayako Nakamura

  • Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice.

    Shigeto Sato;Toshiki Uchihara;Takahiro Fukuda;Sachiko Noda

  • Ataxin-3 is translocated into the nucleus for the formation of intranuclear inclusions in normal and Machado-Joseph disease brains.

    Hiroto Fujigasaki;Toshiki Uchihara;Shigeru Koyano;Kiyoshi Iwabuchi

  • Reader response: Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB consortium.

    Toshiki Uchihara;Shuta Toru

Frequent Co-Authors

Hidehiro Mizusawa
Hidehiro Mizusawa Tokyo Medical and Dental University
Takanori Yokota
Takanori Yokota Institute of Science Tokyo
Akiyoshi Kakita
Akiyoshi Kakita Niigata University
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Heiko Braak
Heiko Braak University of Ulm
Paolo Stanzione
Paolo Stanzione University of Rome Tor Vergata
Nico J. Diederich
Nico J. Diederich Centre Hospitalier de Luxembourg
Sten Grillner
Sten Grillner Karolinska Institute
Hideki Mochizuki
Hideki Mochizuki Osaka University
Giorgio Bernardi
Giorgio Bernardi University of Rome Tor Vergata

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