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Chemistry

D-Index
55
Citations
12402
World Ranking
12017
National Ranking
3225

Overview

Stephen R. Byrn is affiliated with Purdue University West Lafayette in the United States. Their primary field of study is Chemistry, with specific focus areas including Materials Chemistry, Spectroscopy, Pharmaceutical Science, Physical and Theoretical Chemistry, and Analytical Chemistry.

The main topics of their research cover a range of specialized subjects, such as:

  • Crystallography and molecular interactions
  • Drug Solubility and Delivery Systems
  • Crystallization and Solubility Studies
  • Analytical Methods in Pharmaceuticals
  • Analytical Chemistry and Chromatography
  • Advanced NMR Techniques and Applications
  • X-ray Diffraction in Crystallography

Stephen R. Byrn has contributed to scientific literature through publications appearing in several frequent venues. Notable sources include:

  • The Proceedings of the BIRS Community
  • AAPS PharmSciTech
  • Molecular Pharmaceutics
  • International Journal of Pharmaceutics
  • Crystal Growth & Design

Key recent papers reflect a focus on pharmaceutical materials and analysis using advanced techniques such as solid-state NMR and crystallography:

  • "Atomic-Level Drug Substance and Polymer Interaction in Posaconazole Amorphous Solid Dispersion from Solid-State NMR," 2020, Molecular Pharmaceutics
  • "Molecular Mechanism of Crystalline-to-Amorphous Conversion of Pharmaceutical Solids from 19F Magic Angle Spinning NMR," 2020, The Journal of Physical Chemistry B
  • "Molecular packing of pharmaceuticals analyzed with paramagnetic relaxation enhancement and ultrafast magic angle pinning NMR," 2020, Physical Chemistry Chemical Physics
  • "Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory study of the effect of drug loading and the balance of adjuvants on extrudability and dissolution," 2022, International Journal of Pharmaceutics
  • "Ritonavir Form III: A Coincidental Concurrent Discovery," 2022, Crystal Growth & Design

The scientist has collaborated frequently with several co-authors. The most common collaborators include:

  • Kari Clase
  • Daniel T. Smith
  • Pamela A. Smith
  • Mercy A. Okezue
  • Chris J. Benmore

Best Publications

  • Solid state chemistry of drugs

    Stephen R. Byrn

  • Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations

    Stephen Byrn;Ralph Pfeiffer;Michael Ganey;Charles Hoiberg

  • Solid-state analysis of the active pharmaceutical ingredient in drug products.

    Ann W. Newman;Stephen R. Byrn

  • Thermochemistry and Conformational Polymorphism of a Hexamorphic Crystal System

    Lian Yu;Gregory A. Stephenson;Christine A. Mitchell;Charles A. Bunnell

  • Chemical reactivity in solid-state pharmaceuticals: formulation implications.

    Stephen R Byrn;Wei Xu;Ann W Newman

  • Solid-State Nuclear Magnetic Resonance Spectroscopy-Pharmaceutical Applications

    Patrick A. Tishmack;David E. Bugay;Stephen R. Byrn

  • Solid-state pharmaceutical chemistry

    S. R. Byrn;R. R. Pfeiffer;G. Stephenson;D. J. W. Grant

  • Reactivity differences of indomethacin solid forms with ammonia gas

    Xiaoming Chen;Kenneth R. Morris;Ulrich J. Griesser;Stephen R. Byrn

  • Physical characteristics and chemical degradation of amorphous quinapril hydrochloride.

    Yushen Guo;Stephen R. Byrn;George Zografi

  • Hydration and dehydration of crystalline and amorphous forms of raffinose.

    Azita Saleki‐Gerhardt;Joseph G. Stoweell;Stephen R. Byrn;George Zografi

  • Anhydrates and Hydrates of Olanzapine: Crystallization, Solid-State Characterization, and Structural Relationships

    Susan M. Reutzel-Edens;Julie K. Bush;Paula A. Magee;Greg A. Stephenson

  • Glycine Crystallization During Freezing: The Effects of Salt Form, pH, and Ionic Strength

    Michael J. Akers;Nathaniel Milton;Stephen R. Byrn;Steven L. Nail

  • Investigation of drug-excipient interactions in lapatinib amorphous solid dispersions using solid-state NMR spectroscopy.

    Yang Song;Xinghao Yang;Xin Chen;Haichen Nie

  • Achieving Continuous Manufacturing for Final Dosage Formation: Challenges and How to Meet Them. May 20–21, 2014 Continuous Manufacturing Symposium

    Stephen Byrn;Maricio Futran;Hayden Thomas;Eric Jayjock

  • Goniothalenol: a novel, bioactive, tetrahydrofurano-2-pyrone from (annonaceae)

    A.Atef Ebrabim El-Zayat;Nelson R. Ferrigni;Thomas G. McCloud;Ann T. McKenzie

  • A solid‐state approach to enable early development compounds: Selection and animal bioavailability studies of an itraconazole amorphous solid dispersion

    David Engers;Jing Teng;Jonathan Jimenez-Novoa;Philip Gent

  • Solid‐state investigations of erythromycin a dihydrate: Structure, NMR spectroscopy, and hygroscopicity

    Gregory A. StephensonX;Oseph G. Stowell;Pascal H. Toma;Ralph R. Pfeiffer

  • Solid-State Nuclear Magnetic Resonance (NMR) Spectra of Pharmaceutical Dosage Forms

    Patricia J. Saindon;Nina S. Cauchon;Paul A. Sutton;C.-j. Chang

  • Crystal structure, solid-state NMR spectra, and oxygen reactivity of five crystal forms of prednisolone tert-butylacetate

    Stephen R. Byrn;Paul A. Sutton;Brian. Tobias;James. Frye

  • Goniotriol from Goniothalamus giganteus.

    A. Alkofahi;W.-W. Ma;A. T. Mckenzie;S. R. Byrn

  • Solid-State Properties of Pharmaceutical Materials

    George Zografi;Xiaoming (Sean) Chen;Stephen R. Byrn

Frequent Co-Authors

Chris J. Benmore
Chris J. Benmore Argonne National Laboratory
Lynne S. Taylor
Lynne S. Taylor Purdue University West Lafayette
George Zografi
George Zografi University of Wisconsin–Madison
Jeffery L. Yarger
Jeffery L. Yarger Arizona State University
Mark Cushman
Mark Cushman Purdue University West Lafayette
Philip L. Fuchs
Philip L. Fuchs Purdue University West Lafayette
Riyi Shi
Riyi Shi Purdue University West Lafayette
Lian Yu
Lian Yu University of Wisconsin–Madison
Heinz G. Floss
Heinz G. Floss University of Washington
Ming-Daw Tsai
Ming-Daw Tsai Academia Sinica

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