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Ladislav Mrzljak

Ladislav Mrzljak

D-Index & Metrics

Neuroscience

D-Index
35
Citations
6008
World Ranking
9148
National Ranking
3860

Overview

Ladislav Mrzljak is affiliated with the CHDI Foundation in the United States, focusing on research related to genetic neurodegenerative diseases. Their work spans multiple disciplines, including neuroscience, biochemistry, genetics, molecular biology, and medicine.

The primary fields of study for Mrzljak include:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their research also covers several subfields, such as:

  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Neurology
  • Cell Biology
  • Psychiatry and Mental health

Main topics of interest involve:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Neurological disorders and treatments
  • Ubiquitin and proteasome pathways
  • Biotin and Related Studies
  • Phosphodiesterase function and regulation
  • Attention Deficit Hyperactivity Disorder

A selection of recent papers authored or co-authored by Mrzljak includes:

  • "Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand," 2020, Journal of Medicinal Chemistry
  • "PET Molecular Imaging of Phosphodiesterase 10A: An Early Biomarker of Huntington's Disease Progression," 2020, Movement Disorders
  • "Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease," 2022, Science Translational Medicine
  • "Synaptic Vesicle Glycoprotein 2A Is Affected in the Central Nervous System of Mice with Huntington Disease and in the Brain of a Human with Huntington Disease Postmortem," 2021, Journal of Nuclear Medicine
  • "[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins," 2021, Journal of Medicinal Chemistry

Frequent publication venues in which Mrzljak has contributed are:

  • Journal of Medicinal Chemistry
  • Movement Disorders
  • Science Translational Medicine
  • Journal of Nuclear Medicine
  • European Journal of Nuclear Medicine and Molecular Imaging

Collaborations have been an important aspect of their career, working repeatedly with several co-authors, including:

  • Ignacio Muñoz-Sanjuán
  • Celia Dominguez
  • Jonathan Bard
  • Vinod Khetarpal
  • Daniele Bertoglio

Best Publications

  • Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain.

    Clare Bergson;Ladislav Mrzljak;John F. Smiley;Mariamma Pappy

  • Localization of dopamine D4 receptors in GABAergic neurons of the primate brain

    L. Mrzljak;C. Bergson;M. Pappy;R. Huff

  • Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: morphological evidence for cholinergic modulation of excitatory neurotransmission.

    Ladislav Mrzljak;Allan I. Levey;Patricia S. Goldman-Rakic

  • Prominence of the dopamine D2 short isoform in dopaminergic pathways

    Zafar U. Khan;Ladislav Mrzljak;Antonia Gutierrez;Adelaida de la Calle

  • Prenatal development of neurons in the human prefrontal cortex. II. A quantitative Golgi study.

    L. Mrzljak;H. B. M. Uylings;I. Kostovic;C. G. Van Eden

  • Neuronal development in human prefrontal cortex in prenatal and postnatal stages.

    Mrzljak L;Uylings Hb;Van Eden Cg;Judás M

  • Prenatal development of GABA‐ergic neurons in the neocortex of the rat

    C. G. van Eden;L. Mrzljak;P. Voorn;H. B. M. Uylings

  • Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

    Bryan Zeitler;Steven Froelich;Kimberly Marlen;David A. Shivak

  • Muscarinic m1 and m2 receptor proteins in local circuit and projection neurons of the primate striatum: anatomical evidence for cholinergic modulation of glutamatergic prefronto-striatal pathways.

    Adriana A. Alcantara;Ladislav Mrzljak;Robert L. Jakab;Allan I. Levey

  • Basal dendrites of granule cells are normal features of the fetal and adult dentate gyrus of both monkey and human hippocampal formations

    La´szlo´ Seress;Ladislav Mrzljak

  • Postnatal development of mossy cells in the human dentate gyrus: A light microscopic Golgi study

    László Seress;Ladislav Mrzljak

  • Structural basis of the developmental plasticity in the human cerebral cortex: the role of the transient subplate zone.

    Ivica Kostović;Nikola Lukinović;Miloš Judaš;Nenad Bogdanović

  • Development of the human fetal auditory cortex: growth of afferent fibres.

    J Krmpotić-Nemanić;I Kostović;Z Kelović;D Nemanić

  • Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models

    Vahri Beaumont;Sheng Zhong;Hai Lin;WenJin Xu

  • Postnatal maturation of the layer III pyramidal neurons in the human prefrontal cortex: a quantitative Golgi analysis

    Unknown

  • Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.

    Unknown

  • Localization of the m2 muscarinic acetylcholine receptor protein and mRNA in cortical neurons of the normal and cholinergically deafferented rhesus monkey.

    Ladislav Mrzljak;Allan I. Levey;Scott Belcher;P.S. Goldman-Rakic

  • Early onset of synapse formation in the human hippocampus: A correlation with Nissl-Golgi architectonics in 15- and 16.5-week-old fetuses.

    Ivica Kostović;Laszlo Seress;Ladislav Mrzljak;Miloš Judaš

  • Characterization of subtype-specific antibodies to the human D5 dopamine receptor: studies in primate brain and transfected mammalian cells.

    Clare Bergson;Ladislav Mrzljak;Michael S. Lidow;Patricia S. Goldman-Rakic

  • [11C]AZ10419369: a selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET). Characterization in the primate brain.

    M. Edward Pierson;Jan Andersson;Svante Nyberg;Dennis J. McCarthy

  • The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys.

    Zuzana Justinova;Leigh V. Panlilio;Maria E. Secci;Godfrey H. Redhi

  • Nucleus subputaminalis (Ayala): the still disregarded magnocellular component of the basal forebrain may be human specific and connected with the cortical speech area.

    G. Siˇmić;G. Siˇmić;L. Mrzljak;A. Fucˇić;B. Winblad

  • Selective expression of m2 muscarinic receptor in the parvocellular channel of the primate visual cortex.

    Ladislav Mrzljak;Allan I. Levey;Pasko Rakic

Frequent Co-Authors

Ivica Kostović
Ivica Kostović University of Zagreb
László Seress
László Seress University of Pecs
Harry B.M. Uylings
Harry B.M. Uylings Vrije Universiteit Amsterdam
Nada Zecevic
Nada Zecevic University of Connecticut Health Center

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