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Biology and Biochemistry

D-Index
85
Citations
41926
World Ranking
3068
National Ranking
233

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Erik Sahai is a researcher affiliated with The Francis Crick Institute in the United Kingdom. Their work spans key areas within biochemistry, genetics, molecular biology, and medicine, with a particular emphasis on cancer research and cellular biology.

Their primary fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broad fields, Sahai's research delves into subfields such as:

  • Molecular Biology
  • Oncology
  • Immunology
  • Cell Biology
  • Cancer Research

Their main research topics cover:

  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • Cellular Mechanics and Interactions
  • Immune cells in cancer
  • Hippo pathway signaling and YAP/TAZ
  • Cancer Research and Treatments
  • Immunotherapy and Immune Responses

Sahai has contributed numerous papers to the scientific community, including the following recent publications:

  • "A framework for advancing our understanding of cancer-associated fibroblasts", 2020, Nature Reviews. Cancer
  • "SnapShot: Cancer-Associated Fibroblasts", 2020, Cell
  • "A FIJI macro for quantifying pattern in extracellular matrix", 2021, Life Science Alliance
  • "Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination", 2020, Nature Cell Biology
  • "Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms", 2021, Cell Reports

Their frequent coauthors are:

  • Charles Swanton
  • Steven Hooper
  • Emma Colliver
  • Philip Hobson
  • Julian Downward

Scientific contributions by Sahai have frequently appeared in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Trends in Cell Biology
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Cell Biology

Erik Sahai has been recognized by professional societies, holding distinctions including membership in the European Molecular Biology Organization (EMBO) and fellowship in The Academy of Medical Sciences, United Kingdom.

Best Publications

  • A framework for advancing our understanding of cancer-associated fibroblasts

    Erik Sahai;Igor Astsaturov;Edna Cukierman;David G. DeNardo

  • RHO-GTPases and cancer.

    Erik Sahai;Christopher J. Marshall

  • NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

    Jan P. Böttcher;Eduardo Bonavita;Probir Chakravarty;Hanna Blees

  • Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.

    Cedric Gaggioli;Steven Hooper;Cristina Hidalgo-Carcedo;Robert Grosse

  • Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

    Mathew L. Coleman;Erik A. Sahai;Margaret Yeo;Marta Bosch

  • Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

    Erik Sahai;Christopher J Marshall

  • Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

    Fernando Calvo;Nil Ege;Araceli Grande-Garcia;Steven Hooper

  • Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

    Victoria Sanz-Moreno;Gilles Gadea;Jessica Ahn;Hugh Paterson

  • Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

    Santiago Zelenay;Annemarthe G. van der Veen;Jan P. Böttcher;Kathryn J. Snelgrove

  • Classifying collective cancer cell invasion

    Peter Friedl;Joseph Locker;Erik Sahai;Jeffrey E. Segall

  • Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

    Sumanta Goswami;Erik Sahai;Erik Sahai;Jeffrey B. Wyckoff;Michael Cammer

  • A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

    Anna Labernadie;Takuya Kato;Agustí Brugués;Xavier Serra-Picamal

  • Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility.

    Silvia Giampieri;Cerys Manning;Steven Hooper;Louise Jones

  • Physical influences of the extracellular environment on cell migration

    Guillaume Charras;Erik Sahai

  • Illuminating the metastatic process

    Erik Sahai

  • Mechanisms of cancer cell invasion.

    Erik Sahai

  • The actin cytoskeleton in cancer cell motility.

    Michael F Olson;Erik A Sahai

  • Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

    Eishu Hirata;Maria Romina Girotti;Amaya Viros;Steven Hooper

  • ROCK and Dia have opposing effects on adherens junctions downstream of Rho

    Erik Sahai;Christopher J. Marshall

  • Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors

    Weigang Wang;Sumanta Goswami;Kyle Lapidus;Amber L. Wells

Frequent Co-Authors

John S. Condeelis
John S. Condeelis Albert Einstein College of Medicine
Guillaume Charras
Guillaume Charras London Centre for Nanotechnology
Christopher J. Marshall
Christopher J. Marshall Institute of Cancer Research
Paul A. Bates
Paul A. Bates The Francis Crick Institute
Jeffrey E. Segall
Jeffrey E. Segall Albert Einstein College of Medicine
Richard Marais
Richard Marais University of Manchester
Kevin J. Harrington
Kevin J. Harrington Royal Marsden NHS Foundation Trust
Michael F. Olson
Michael F. Olson Toronto Metropolitan University
James Larkin
James Larkin Royal Marsden NHS Foundation Trust
Charles Swanton
Charles Swanton The Francis Crick Institute

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