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Stephan Pleschka

Stephan Pleschka

D-Index & Metrics

Microbiology

D-Index
47
Citations
10213
World Ranking
4757
National Ranking
328

Overview

Stephan Pleschka is affiliated with the University of Giessen in Germany and has a research focus primarily in the fields of Medicine and Immunology and Microbiology. Their work encompasses several subfields, notably Epidemiology, Immunology, Infectious Diseases, Molecular Biology, and Agronomy and Crop Science.

The main topics addressed in Stephan Pleschka's research include Influenza Virus Research Studies, interferon and immune responses, Respiratory viral infections research, Animal Disease Management and Epidemiology, SARS-CoV-2 and COVID-19 Research, Animal Virus Infections Studies, and RNA modifications and cancer.

Frequent publication venues for their research papers are:

  • PLoS Pathogens
  • Viruses
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Antiviral Research
  • Scientific Reports

Stephan Pleschka has collaborated with a number of co-authors including Ahmed Mostafa, Mahmoud Shehata, Christin Müller, Frank Peßler, and Klaus Schughart.

Selected recent publications include:

  • Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism, 2022, Nature Metabolism
  • Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection, 2022, PLoS Pathogens
  • Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways, 2020, Journal of Biological Chemistry
  • NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner, 2023, PLoS Pathogens
  • The rocaglate CR-31-B (−) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo, 2021, Antiviral Research

Best Publications

  • Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade

    Stephan Pleschka;Thorsten Wolff;Christina Ehrhardt;Gerd Hobom

  • Caspase 3 activation is essential for efficient influenza virus propagation

    Walter J. Wurzer;Oliver Planz;Christina Ehrhardt;Martin Giner

  • Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

    Susanne Herold;Mirko Steinmueller;Werner von Wulffen;Lidija Cakarova

  • A plasmid-based reverse genetics system for influenza A virus.

    S Pleschka;R Jaskunas;O G Engelhardt;T Zürcher

  • Influenza A Virus NS1 Protein Activates the PI3K/Akt Pathway To Mediate Antiapoptotic Signaling Responses

    Christina Ehrhardt;Thorsten Wolff;Stephan Pleschka;Oliver Planz

  • Interdependence of hemagglutinin glycosylation and neuraminidase as regulators of influenza virus growth: a study by reverse genetics.

    Ralf Wagner;Thorsten Wolff;Astrid Herwig;Stephan Pleschka

  • NF-κB-dependent Induction of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Fas/FasL Is Crucial for Efficient Influenza Virus Propagation

    Walter J. Wurzer;Christina Ehrhardt;Stephan Pleschka;Friederike Berberich-Siebelt

  • Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence.

    Christina Ehrhardt;Henju Marjuki;Thorsten Wolff;Bernd Nürnberg

  • Negative-strand RNA viruses: genetic engineering and applications.

    Peter Palese;Hongyong Zheng;Othmar G. Engelhardt;Stephan Pleschka

  • Alveolar Epithelial Cells Direct Monocyte Transepithelial Migration upon Influenza Virus Infection: Impact of Chemokines and Adhesion Molecules

    Susanne Herold;Werner von Wulffen;Mirko Steinmueller;Stephan Pleschka

  • Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview.

    Ahmed Mostafa;Elsayed M Abdelwhab;Thomas C Mettenleiter;Stephan Pleschka

  • Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells

    Stephan Ludwig;Stephan Pleschka;Oliver Planz;Thorsten Wolff

  • Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses

    Christian Krawitz;Mobarak Abu Mraheil;Michael Stein;Can Imirzalioglu

  • The Influenza A Virus NS1 Protein Inhibits Activation of Jun N-Terminal Kinase and AP-1 Transcription Factors

    Stephan Ludwig;Xiuyan Wang;Christina Ehrhardt;Hongyong Zheng

  • Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

    Katrin Högner;Thorsten Wolff;Stephan Pleschka;Stephanie Plog

  • Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappa B-inhibiting activity

    Igor Mazur;Walter J. Wurzer;Christina Ehrhardt;Stephan Pleschka

  • Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway.

    Stephan Ludwig;Christina Ehrhardt;Elisabeth R. Neumeier;Michael Kracht

  • Influenza-virus-induced signaling cascades: targets for antiviral therapy?

    Stephan Ludwig;Oliver Planz;Stephan Pleschka;Thorsten Wolff

  • Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses.

    Christin Müller;Falk W. Schulte;Kerstin Lange-Grünweller;Wiebke Obermann

  • Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian Influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)

    Stephan Pleschka;Michael Stein;Roland Schoop;James B Hudson

  • Membrane Accumulation of Influenza A Virus Hemagglutinin Triggers Nuclear Export of the Viral Genome via Protein Kinase Cα-mediated Activation of ERK Signaling

    Henju Marjuki;Mohammad I. Alam;Christina Ehrhardt;Ralf Wagner

Frequent Co-Authors

Stephan Ludwig
Stephan Ludwig University of Münster
Oliver Planz
Oliver Planz University of Tübingen
Thorsten Wolff
Thorsten Wolff Robert Koch Institute
Susanne Herold
Susanne Herold University of Giessen
John Ziebuhr
John Ziebuhr University of Giessen
Werner Seeger
Werner Seeger University of Giessen
Klaus Schughart
Klaus Schughart Helmholtz Centre for Infection Research
Ulf R. Rapp
Ulf R. Rapp Max Planck Society
Hans-Dieter Klenk
Hans-Dieter Klenk Philipp University of Marburg
Roland Zell
Roland Zell Friedrich Schiller University Jena

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