The scientist’s investigation covers issues in Cell biology, Biochemistry, Proteomics, Proteome and Stable isotope labeling by amino acids in cell culture. Marcus Krüger is interested in Signal transduction, which is a branch of Cell biology. The Oxidative phosphorylation, Inner mitochondrial membrane, Membrane protein and Mitochondrion research Marcus Krüger does as part of his general Biochemistry study is frequently linked to other disciplines of science, such as Proteases, therefore creating a link between diverse domains of science.
His study in Proteomics is interdisciplinary in nature, drawing from both Amino acid, Pathogenesis and Protein family. His Stable isotope labeling by amino acids in cell culture study integrates concerns from other disciplines, such as Insulin receptor and Phosphorylation, Tyrosine phosphorylation. While the research belongs to areas of Gene expression, he spends his time largely on the problem of Lesion, intersecting his research to questions surrounding Internal medicine.
Marcus Krüger mainly focuses on Cell biology, Biochemistry, Proteome, Internal medicine and Stable isotope labeling by amino acids in cell culture. Cell biology and Chromatin are frequently intertwined in his study. His Proteome research is multidisciplinary, incorporating elements of Molecular biology, Transcriptome and Proteomics.
His research in Proteomics intersects with topics in Gene expression and Computational biology. Marcus Krüger combines subjects such as Endocrinology and Cardiology with his study of Internal medicine. His Stable isotope labeling by amino acids in cell culture research is multidisciplinary, incorporating perspectives in Lysine, Quantitative proteomics and Model organism.
His primary areas of study are Cell biology, Phosphorylation, Cancer research, Chromatin and Kinase. He has researched Cell biology in several fields, including Cell, Programmed cell death and Skeletal muscle. His Phosphorylation study combines topics in areas such as Acetyltransferase, Titin, Organelle and Interactome.
The concepts of his Cancer research study are interwoven with issues in Phenotype, Effector, Tumor microenvironment and Lymphoma. His biological study spans a wide range of topics, including Gene silencing, Epigenetics and Genome instability. His work in Denervation covers topics such as Myosin which are related to areas like Proteomics.
Marcus Krüger mostly deals with Cell biology, Chromatin, Epigenetics, Gene silencing and Kinase. Marcus Krüger works in the field of Cell biology, namely PI3K/AKT/mTOR pathway. The Chromatin study combines topics in areas such as Non-homologous end joining, Homologous recombination, Genome instability and Mutation.
His Epigenetics research integrates issues from H3K4me3, Angiogenesis and Gene expression. Marcus Krüger has included themes like Heterochromatin and Non-coding RNA, microRNA in his Gene silencing study. The concepts of his Kinase study are interwoven with issues in Cyclin-dependent kinase, Protein kinase B, Signal transduction and Stable isotope labeling by amino acids in cell culture.
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Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy
Richard S. Finkel;Eugenio Mercuri;Basil T. Darras;Anne M. Connolly.
The New England Journal of Medicine (2017)
Genetic compensation induced by deleterious mutations but not gene knockdowns
Andrea Rossi;Zacharias Kontarakis;Claudia Gerri;Hendrik Nolte.
SILAC Mouse for Quantitative Proteomics Uncovers Kindlin-3 as an Essential Factor for Red Blood Cell Function
Marcus Krüger;Markus Moser;Siegfried Ussar;Ingo Thievessen.
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster
Thomas Boettger;Nadine Beetz;Sawa Kostin;Johanna Schneider.
Journal of Clinical Investigation (2009)
The Failing Heart Relies on Ketone Bodies as a Fuel
Gregory Aubert;Ola J. Martin;Julie L. Horton;Ling Lai.
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
Virginia Guarani;Gianluca Deflorian;Claudio A Franco;Marcus Kruger.
Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics
Tamar Geiger;Jacek R Wisniewski;Juergen Cox;Sara Zanivan.
Nature Protocols (2011)
Dissection of the insulin signaling pathway via quantitative phosphoproteomics.
Marcus Krüger;Irina Kratchmarova;Blagoy Blagoev;Yu-Hua Tseng.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Systems-wide proteomic analysis in mammalian cells reveals conserved, functional protein turnover.
Sidney B. Cambridge;Florian Gnad;Chuong Nguyen;Justo Lorenzo Bermejo.
Journal of Proteome Research (2011)
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation
Lourdes Serrano;Paloma Martínez-Redondo;Anna Marazuela-Duque;Berta N. Vazquez.
Genes & Development (2013)
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