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Biology and Biochemistry

D-Index
78
Citations
28008
World Ranking
4470
National Ranking
329

Overview

Thomas Benzing is affiliated with the University of Cologne in Germany and has a focused research career in medicine, particularly nephrology and molecular biology. Their scholarly output includes significant contributions to the understanding of renal diseases, genetic factors in kidney health, and the molecular mechanisms underlying kidney function and pathology.

Their research spans several main fields of study including:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Subfields of study involving their work cover:

  • Nephrology
  • Molecular Biology
  • Genetics
  • Immunology
  • Oncology

The research topics most commonly addressed include:

  • Renal Diseases and Glomerulopathies
  • Renal and related cancers
  • Genetic and Kidney Cyst Diseases
  • Chronic Kidney Disease and Diabetes
  • Frailty in Older Adults
  • Genetics, Aging, and Longevity in Model Organisms
  • Dialysis and Renal Disease Management

Among recent publications, notable papers include:

  • "After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy," 2020, Kidney International
  • "Insights into Glomerular Filtration and Albuminuria," 2021, New England Journal of Medicine
  • "Ageing-associated changes in transcriptional elongation influence longevity," 2023, Nature
  • "A molecular mechanism explaining albuminuria in kidney disease," 2020, Nature Metabolism
  • "Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes," 2021, Nature Communications

Frequent collaborators in research include:

  • Bernhard Schermer
  • Paul T. Brinkkoetter
  • Martin Höhne
  • David Unnersjö-Jess
  • Roman-Ulrich Müller

Their work has been published in leading scientific venues, with multiple publications appearing in:

  • Journal of the American Society of Nephrology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Kidney International
  • Journal of cardiovascular computed tomography
  • Scientific Reports

Best Publications

  • A mammalian microRNA expression atlas based on small RNA library sequencing.

    Pablo Landgraf;Mirabela Rusu;Robert Sheridan;Alain Sewer;Alain Sewer

  • When cilia go bad: cilia defects and ciliopathies

    Manfred Fliegauf;Thomas Benzing;Heymut Omran

  • Pre-eclampsia: pathogenesis, novel diagnostics and therapies.

    Elizabeth A. Phipps;Elizabeth A. Phipps;Ravi Thadhani;Ravi Thadhani;Thomas Benzing;S. Ananth Karumanchi;S. Ananth Karumanchi

  • Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

    Matias Simons;Joachim Gloy;Athina Ganner;Axel Bullerkotte

  • Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.

    Edgar A. Otto;Bernhard Schermer;Tomoko Obara;John F. O'Toole

  • Interaction with Podocin Facilitates Nephrin Signaling

    Tobias B. Huber;Michael Köttgen;Birgit Schilling;Gerd Walz

  • Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.

    Tobias B. Huber;Björn Hartleben;Jeong Kim;Miriam Schmidts

  • Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

    Moumita Chaki;Rannar Airik;Amiya K. Ghosh;Rachel H. Giles

  • Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

    Heike Olbrich;Manfred Fliegauf;Julia Hoefele;Andreas Kispert

  • Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia

    Ravi Thadhani;Tuelay Kisner;Henning Hagmann;Verena Bossung

  • Loss of Nephrocystin-3 Function Can Cause Embryonic Lethality, Meckel-Gruber-like Syndrome, Situs Inversus, and Renal-Hepatic-Pancreatic Dysplasia

    Carsten Bergmann;Manfred Fliegauf;Nadina Ortiz Brüchle;Valeska Frank

  • Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular Disease

    Scott J. Harvey;George Jarad;Jeanette Cunningham;Seth Goldberg

  • Molecular basis of the functional podocin–nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

    Tobias B. Huber;Matias Simons;Björn Hartleben;Leonie Sernetz

  • Signaling at the Slit Diaphragm

    Thomas Benzing

  • Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.

    Tobias B. Huber;Bernhard Schermer;Roman Ulrich Müller;Martin Höhne

  • The Polycystic Kidney Disease 1 Gene Product Modulates Wnt Signaling

    Emily Kim;Thierry Arnould;Lorenz K. Sellin;Thomas Benzing

  • The slit diaphragm: a signaling platform to regulate podocyte function.

    Tobias B Huber;Thomas Benzing

  • Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia

    Ravi Thadhani;Henning Hagmann;Wiebke Schaarschmidt;Bernhard Roth

  • Ischemic Preconditioning for Prevention of Contrast Medium–Induced Nephropathy

    Fikret Er;Amir M. Nia;Henning Dopp;Martin Hellmich

  • Erratum: When cilia go bad: cilia defects and ciliopathies

    Manfred Fliegauf;Thomas Benzing;Heymut Omran

Frequent Co-Authors

Bernhard Schermer
Bernhard Schermer University of Cologne
Tobias B. Huber
Tobias B. Huber Universität Hamburg
Gerd Walz
Gerd Walz University of Freiburg
Oliver Kretz
Oliver Kretz Universität Hamburg
S. Ananth Karumanchi
S. Ananth Karumanchi Cedars-Sinai Medical Center
Ravi Thadhani
Ravi Thadhani Harvard University
Stuart E. Dryer
Stuart E. Dryer University of Houston
Heymut Omran
Heymut Omran University of Münster
Hanswalter Zentgraf
Hanswalter Zentgraf German Cancer Research Center
Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital

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