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Biology and Biochemistry

D-Index
55
Citations
8674
World Ranking
15261
National Ranking
480

Overview

Silvia Soddu is affiliated with Sapienza University of Rome in Italy and contributes extensively to the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their work spans multiple subfields, including Molecular Biology, Cell Biology, Oncology, Genetics, and Cancer Research.

Their research focuses on key topics such as:

  • Microtubule and mitosis dynamics
  • Cancer-related molecular pathways
  • DNA repair mechanisms
  • Ubiquitin and proteasome pathways
  • Cancer genomics and diagnostics
  • Radiation therapy and dosimetry
  • Hereditary neurological disorders

Soddu has published in various scientific venues with a frequency in the following journals:

  • Journal of Experimental & Clinical Cancer Research
  • Life Science Alliance
  • Cancers
  • Cancer Letters
  • Proceedings of the National Academy of Sciences

Some of the recent notable publications include:

  • "Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers," 2020, Journal of Experimental & Clinical Cancer Research
  • "Factors to Consider for the Correct Use of γH2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing Radiation," 2022, Cancers
  • "Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation," 2020, Life Science Alliance
  • "TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability," 2020, Cancer Letters
  • "The Cockayne syndrome group A and B proteins are part of a ubiquitin-proteasome degradation complex regulating cell division," 2020, Proceedings of the National Academy of Sciences

Frequent collaborators in Silvia Soddu's research work include:

  • Laura Monteonofrio
  • Cinzia Rinaldo
  • G. Federici
  • Davide Valente
  • Alessandra Verdina

Best Publications

  • Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

    Gabriella D'Orazi;Barbara Cecchinelli;Tiziana Bruno;Isabella Manni

  • p53 Expression in B-Cell Chronic Lymphocytic Leukemia: A Marker of Disease Progression and Poor Prognosis

    Iole Cordone;Serena Masi;Serena Masi;Francesca Romana Mauro;Francesca Romana Mauro;Silvia Soddu;Silvia Soddu

  • P53 Inhibits α6β4 Integrin Survival Signaling by Promoting the Caspase 3–Dependent Cleavage of Akt/PKB

    Robin E. Bachelder;Robin E. Bachelder;Mark J. Ribick;Mark J. Ribick;Alessandra Marchetti;Rita Falcioni

  • MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

    Cinzia Rinaldo;Andrea Prodosmo;Francesca Mancini;Stefano Iacovelli

  • NF-Y Mediates the Transcriptional Inhibition of thecyclin B1, cyclin B2, and cdc25CPromoters upon Induced G2 Arrest

    Isabella Manni;Giuseppina Mazzaro;Aymone Gurtner;Roberto Mantovani

  • TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

    Richard Tomasini;Amina Azizi Samir;Alice Carrier;Daniel Isnardon

  • p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells

    Fabiola Moretti;Antonella Farsetti;Silvia Soddu;Silvia Misiti

  • Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways.

    Barbara Valentinis;Gaetano Romano;Francesca Peruzzi;Andrea Morrione

  • Interference with p53 protein inhibits hematopoietic and muscle differentiation.

    Silvia Soddu;Giovanni Blandino;Raffaella Scardigli;Sabrina Coen

  • The Loss of the p53 Activator HIPK2 Is Responsible for Galectin-3 Overexpression in Well Differentiated Thyroid Carcinomas

    Luca Lavra;Cinzia Rinaldo;Alessandra Ulivieri;Emidio Luciani

  • p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle.

    Marilena Ciciarello;Rosamaria Mangiacasale;Martina Casenghi;Maria Zaira Limongi

  • Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers.

    Giulia Federici;Silvia Soddu

  • Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.

    Tiziana Bruno;Francesca De Nicola;Simona Iezzi;Daniele Lecis

  • P53 Regulates Myogenesis by Triggering the Differentiation Activity of Prb

    Alessandro Porrello;Maria Antonietta Cerone;Sabrina Coen;Aymone Gurtner

  • From p63 to p53 across p73

    Sabrina Strano;Mario Rossi;Giulia Fontemaggi;Eliana Munarriz

  • HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

    Cinzia RinaldoC. Rinaldo;Andrea ProdosmoA. Prodosmo;Francesca SiepiF. Siepi;Silvia SodduS. Soddu

  • Repression of the Antiapoptotic Molecule Galectin-3 by Homeodomain-Interacting Protein Kinase 2-Activated p53 Is Required for p53-Induced Apoptosis

    Barbara Cecchinelli;Luca Lavra;Cinzia Rinaldo;Stefano Iacovelli

  • p53 Localization at Centrosomes during Mitosis and Postmitotic Checkpoint Are ATM-dependent and Require Serine 15 Phosphorylation

    A. Tritarelli;E. Oricchio;M. Ciciarello;R. Mangiacasale

  • Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis.

    Valeria Di Stefano;Cinzia Rinaldo;Ada Sacchi;Silvia Soddu

  • Che-1 phosphorylation by ATM/ATR and CHK2 kinases activates p53 transcription and the g2/m checkpoint

    Tiziana Bruno;Francesca de nicola;Simona iezzi;Monica di padova

Frequent Co-Authors

Ada Sacchi
Ada Sacchi Istituti Fisioterapici Ospitalieri
Giovanni Blandino
Giovanni Blandino McMaster University
Alfredo Fusco
Alfredo Fusco University of Naples Federico II
Fernando Aiuti
Fernando Aiuti Sapienza University of Rome
Marcella Mottolese
Marcella Mottolese IRCCS Regina Elena Institute
Carlo Gaetano
Carlo Gaetano Goethe University Frankfurt
Renato Baserga
Renato Baserga Thomas Jefferson University
Giuseppe Viglietto
Giuseppe Viglietto Magna Graecia University
Domenico Delia
Domenico Delia University of Milan
Matilde Todaro
Matilde Todaro University of Palermo

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