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Biology and Biochemistry

D-Index
90
Citations
27001
World Ranking
2452
National Ranking
1300

Overview

Arthur M. Mercurio is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, and Medicine, with a significant focus on Molecular Biology and Cancer Research.

The primary subfields of Mercurio's work include Molecular Biology, Cancer Research, Oncology, Pulmonary and Respiratory Medicine, and Cell Biology. Their research topics emphasize Angiogenesis and VEGF in Cancer, Cancer, Hypoxia, and Metabolism, Ferroptosis and cancer prognosis, Cancer-related molecular mechanisms research, Cancer Cells and Metastasis, Cell Adhesion Molecules Research, and Cancer Immunotherapy and Biomarkers.

Mercurio has published extensively, with several recent papers that illustrate the scope of their research interests:

  • "Tumor cell-organized fibronectin maintenance of a dormant breast cancer population" (2020) published in Science Advances
  • "Targeting prominin2 transcription to overcome ferroptosis resistance in cancer" (2021) published in EMBO Molecular Medicine
  • "Protocol for the separation of extracellular vesicles by ultracentrifugation from in vitro cell culture models" (2021) published in STAR Protocols
  • "Differentiation of Cancer Stem Cells through Nanoparticle Surface Engineering" (2020) published in ACS Nano
  • "Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells" (2023) published in Nature

Frequent co-authors in Mercurio's publications suggest collaboration with researchers specializing in closely related fields. These include Hira Lal Goel, Christi A Wisniewski, Lihua Julie Zhu, Ayush Kumar, and Emmet R. Karner.

Mercurio's work has been published repeatedly in several academic venues, reflecting ongoing contributions to the biomedical research community. Frequent publication outlets include Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Cancer Research, Science Advances, bioRxiv (Cold Spring Harbor Laboratory), and Science Translational Medicine.

Best Publications

  • Galectins: a family of animal beta-galactoside-binding lectins.

    Samuel H. Barondes;Vincent Castronovo;Douglas N W Cooper;Richard D. Cummings

  • VEGF targets the tumour cell

    Hira Lal Goel;Arthur M. Mercurio

  • Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

    Leslie M Shaw;Isaac Rabinovitz;Helen H.-F Wang;Alex Toker

  • Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor.

    Eduardo A. C. Almeida;A. P.J. Huovila;A. E. Sutherland;L. E. Stephens

  • Vascular Endothelial Growth Factor Is an Autocrine Survival Factor for Neuropilin-expressing Breast Carcinoma Cells

    Robin E. Bachelder;Aimee Crago;Jun Chung;Melissa A. Wendt

  • Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.

    Robin E. Bachelder;Melissa A. Wendt;Arthur M. Mercurio

  • Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription implications for the epithelial–mesenchymal transition

    Robin E. Bachelder;Sang-Oh Yoon;Clara Franci;Antonio García de Herreros

  • Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma

    Richard C. Bates;David I. Bellovin;Courtney Brown;Elizabeth Maynard

  • ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.

    Paul Mak;Irwin Leav;Bryan M. Pursell;Donggoo Bae

  • Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

    Caitlin W. Brown;John J. Amante;Peter Chhoy;Ameer L. Elaimy

  • Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids.

    Richard C. Bates;Arthur M. Mercurio

  • The alpha 6 beta 4 integrin and epithelial cell migration

    Arthur M Mercurio;Isaac Rabinovitz;Leslie M Shaw

  • The integrin alpha 6 beta 4 is a laminin receptor.

    Edward C. Lee;Margaret M. Lotz;Glenn D. Steele Jr.;Arthur M. Mercurio

  • The epithelial-mesenchymal transition (EMT) and colorectal cancer progression.

    Richard C. Bates;Arthur M. Mercurio

  • The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2).

    Hee-Jong Woo;Leslie M. Shaw;Jeanne M. Messier;Arthur M. Mercurio

  • IAP Regulation of Metastasis

    Swarna Mehrotra;Lucia R. Languino;Christopher M. Raskett;Arthur M. Mercurio

  • The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin.

    Leslie M. Shaw;Jeanne M. Messier;Arthur M. Mercurio

  • The Integrin α6β4 Functions in Carcinoma Cell Migration on Laminin-1 by Mediating the Formation and Stabilization of Actin-containing Motility Structures

    Isaac Rabinovitz;Arthur M. Mercurio

  • Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin.

    Arthur M. Mercurio;Isaac Rabinovitz

  • Proteases, extracellular matrix, and cancer: a workshop of the path B study section.

    Yves A. DeClerck;Arthur M. Mercurio;M. Sharon Stack;Harold A. Chapman

Frequent Co-Authors

Leslie M. Shaw
Leslie M. Shaw University of Pennsylvania
Glenn Steele
Glenn Steele Geisinger Health System
Ulla M. Wewer
Ulla M. Wewer University of Copenhagen
Lihua Julie Zhu
Lihua Julie Zhu University of Massachusetts Chan Medical School
Leonard D. Shultz
Leonard D. Shultz Jackson Laboratory
Dale L. Greiner
Dale L. Greiner University of Massachusetts Chan Medical School
Roger J. Davis
Roger J. Davis University of Massachusetts Chan Medical School
Vincent M. Rotello
Vincent M. Rotello University of Massachusetts Amherst
Peter Oettgen
Peter Oettgen Beth Israel Deaconess Medical Center
Phillips W. Robbins
Phillips W. Robbins Boston University

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