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Immunology

D-Index
69
Citations
30029
World Ranking
2465
National Ranking
96

Overview

Hiroko Tsutsui is affiliated with Hyogo College of Medicine in Japan and has contributed to research primarily within the field of Medicine. Their work is specialized in several subfields including Oncology, Surgery, Immunology, Epidemiology, and Genetics. The scientist's research topics prominently feature cancer immunotherapy and biomarkers, intestinal and peritoneal adhesions, immunotherapy and immune responses, immune cell function and interaction, coagulation mechanisms including bradykinin and polyphosphates, blood coagulation and thrombosis mechanisms, and the relationship between tryptophan and brain disorders.

Tsutsui has published extensively, with a notable focus on understanding immune responses in cancer and postoperative conditions. Their recent papers include:

  • Antithrombin Together with NETs Inhibitor Protected Against Postoperative Adhesion Formation in Mice (2021, Cellular Physiology and Biochemistry)
  • Caffeine Protects Against Stress-Induced Murine Depression Through Activation of PPARγC1α-Mediated Restoration of the Kynurenine Pathway in the Skeletal Muscle (2021, Scientific Reports)
  • Blockade of Tumor Necrosis Factor by Etanercept Prevents Postoperative Adhesion Formation in Mice (2020, Cellular Physiology and Biochemistry)
  • Carbon Ion Irradiation Activates Anti-Cancer Immunity (2024, International Journal of Molecular Sciences)
  • Autophagy Inhibition Increased Sensitivity of Pancreatic Cancer Cells to Carbon Ion Radiotherapy (2023, Cellular Physiology and Biochemistry)

Publications have been frequently featured in venues such as Cellular Physiology and Biochemistry, International Journal of Molecular Sciences, Scientific Reports, Cureus, and the Journal of Hepato-Biliary-Pancreatic Sciences.

Collaborative research is a significant aspect of Tsutsui's work. Frequent coauthors include:

  • Jiro Fujimoto
  • Keiko Mitani
  • Makoto Sudo
  • Etsuro Hatano
  • Shuhei Hayashi

The combination of fields and topics indicate a cross-disciplinary approach to investigating both basic and translational aspects of medical science, with an emphasis on cancer biology and surgical immunology. The continuous publishing pattern suggests ongoing active engagement in research that bridges laboratory findings and potential clinical applications.

Best Publications

  • Cloning of a new cytokine that induces IFN-gamma production by T cells.

    H Okamura;H Tsutsi;T Komatsu;M Yutsudo

  • Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

    Osamu Adachi;Taro Kawai;Kiyoshi Takeda;Makoto Matsumoto

  • Interleukin-18 regulates both Th1 and Th2 responses.

    Kenji Nakanishi;Tomohiro Yoshimoto;Hiroko Tsutsui;Haruki Okamura

  • Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

    Yong Gu;Keisuke Kuida;Hiroko Tsutsui;George Ku

  • Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

    Kiyoshi Takeda;Hiroko Tsutsui;Tomohiro Yoshimoto;Osamu Adachi

  • Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu.

    Kenji Nakanishi;Tomohiro Yoshimoto;Hiroko Tsutsui;Haruki Okamura

  • Hepatocyte growth factor gene therapy of liver cirrhosis in rats.

    Takahiro Ueki;Yasufumi Kaneda;Hiroko Tsutsui;Kenji Nakanishi

  • SOCS-1 participates in negative regulation of LPS responses.

    Reiko Nakagawa;Tetsuji Naka;Hiroko Tsutsui;Minoru Fujimoto

  • Regulation of interferon-gamma production by IL-12 and IL-18

    Haruki Okamura;Shin-ichiro Kashiwamura;Hiroko Tsutsui;Tomohiro Yoshimoto

  • INTERLEUKIN-18: A NOVEL CYTOKINE THAT AUGMENTS BOTH INNATE AND ACQUIRED IMMUNITY

    Haruki Okamura;Hiroko Tsutsui;Shin-Ichiro Kashiwamura;Tomohiro Yoshimoto

  • IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

    Tomohiro Yoshimoto;Hiroko Tsutsui;Kouji Tominaga;Katsuaki Hoshino

  • IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

    H Tsutsui;K Nakanishi;K Matsui;K Higashino

  • Interleukin-18 in Health and Disease

    Koubun Yasuda;Kenji Nakanishi;Hiroko Tsutsui

  • IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6.

    Tomohiro Yoshimoto;Hitoshi Mizutani;Hiroko Tsutsui;Nancy Noben-Trauth

  • Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells.

    Nobuhiko Kayagaki;Noriko Yamaguchi;Masafumi Nakayama;Kazuyoshi Takeda

  • Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor

    Katsuaki Hoshino;Hiroko Tsutsui;Taro Kawai;Kiyoshi Takeda

  • IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.

    Hiroshi Konishi;Hiroko Tsutsui;Takaaki Murakami;Shizue Yumikura-Futatsugi

  • Contribution of IL-33–activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

    Koubun Yasuda;Taichiro Muto;Tatsukata Kawagoe;Makoto Matsumoto

  • Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice.

    Hiroko Tsutsui;Nobuhiko Kayagaki;Keisuke Kuida;Hiroki Nakano

  • Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice

    Ekihiro Seki;Hiroko Tsutsui;Noriko M. Tsuji;Nobuki Hayashi

Frequent Co-Authors

Kenji Nakanishi
Kenji Nakanishi Hyogo College of Medicine
Haruki Okamura
Haruki Okamura Hyogo College of Medicine
Shizuo Akira
Shizuo Akira Osaka University
Tomohiro Yoshimoto
Tomohiro Yoshimoto Hyogo College of Medicine
Kiyoshi Takeda
Kiyoshi Takeda Osaka University
Tetsuji Naka
Tetsuji Naka Kōchi University
Osamu Takeuchi
Osamu Takeuchi Kyoto University
Tadamitsu Kishimoto
Tadamitsu Kishimoto Osaka University
Shun'ichiro Taniguchi
Shun'ichiro Taniguchi Shinshu University
Norifumi Kawada
Norifumi Kawada Osaka Metropolitan University

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