World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
85
Citations
38775
World Ranking
1297
National Ranking
50

Medicine

D-Index
86
Citations
39456
World Ranking
13891
National Ranking
414

Overview

Kenji Nakanishi is affiliated with the Hyogo College of Medicine in Japan. Their research primarily focuses on the fields of immunology and microbiology, as well as medicine, with a significant body of work spanning immunology, surgery, molecular biology, emergency medical services, and epidemiology.

The scientist's main topics of investigation include:

  • IL-33, ST2, and ILC Pathways
  • Eosinophilic Esophagitis
  • Interferon and immune responses
  • Pediatric health and respiratory diseases
  • Retinoids in leukemia and cellular processes
  • Immune cells in cancer
  • Vaccines and immunoinformatics approaches

Their recent scientific publications cover a range of immunological and molecular biology subjects, including:

  • "Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2," 2020, published in International Immunology
  • "Retinoblastoma-binding Protein 9 Suppresses Intestinal Inflammation and Inflammation-induced Tumorigenesis in Mice," 2024, published in Cellular and Molecular Gastroenterology and Hepatology
  • "An adjuvant database for preclinical evaluation of vaccines and immunotherapeutics," 2025, published in Cell Chemical Biology
  • "325 Cutaneous group 2 innate lymphoid cells migrate to draining lymph nodes in mice with IL-33-induced atopic dermatitis-like inflammation," 2020, published in Journal of Investigative Dermatology

Frequent publication venues for their work include:

  • International Immunology
  • Cellular and Molecular Gastroenterology and Hepatology
  • Cell Chemical Biology
  • Journal of Investigative Dermatology

Kenji Nakanishi has collaborated extensively with several researchers. Frequent co-authors include:

  • Etsushi Kuroda
  • Koubun Yasuda
  • Takumi Adachi
  • Ken J. Ishii
  • Masaki Ohmuraya

Best Publications

  • Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

    Osamu Adachi;Taro Kawai;Kiyoshi Takeda;Makoto Matsumoto

  • Essential role of Stat6 in IL-4 signalling

    Kiyoshi Takeda;Takashi Tanaka;Wei Shi;Makoto Matsumoto

  • Interleukin-18 regulates both Th1 and Th2 responses.

    Kenji Nakanishi;Tomohiro Yoshimoto;Hiroko Tsutsui;Haruki Okamura

  • Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

    Yong Gu;Keisuke Kuida;Hiroko Tsutsui;George Ku

  • Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

    Kiyoshi Takeda;Hiroko Tsutsui;Tomohiro Yoshimoto;Osamu Adachi

  • The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

    Takashi Satoh;Osamu Takeuchi;Alexis Vandenbon;Koubun Yasuda

  • IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

    Tomohiro Yoshimoto;Kiyoshi Takeda;Takashi Tanaka;Kazunobu Ohkusu

  • Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression

    Fumiko Nomura;Sachiko Akashi;Yoshimitsu Sakao;Shintaro Sato

  • Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu.

    Kenji Nakanishi;Tomohiro Yoshimoto;Hiroko Tsutsui;Haruki Okamura

  • Hepatocyte growth factor gene therapy of liver cirrhosis in rats.

    Takahiro Ueki;Yasufumi Kaneda;Hiroko Tsutsui;Kenji Nakanishi

  • SOCS-1 participates in negative regulation of LPS responses.

    Reiko Nakagawa;Tetsuji Naka;Hiroko Tsutsui;Minoru Fujimoto

  • Regulation of interferon-gamma production by IL-12 and IL-18

    Haruki Okamura;Shin-ichiro Kashiwamura;Hiroko Tsutsui;Tomohiro Yoshimoto

  • Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells.

    Tomohiro Yoshimoto;Koubun Yasuda;Hidehisa Tanaka;Masakiyo Nakahira

  • INTERLEUKIN-18: A NOVEL CYTOKINE THAT AUGMENTS BOTH INNATE AND ACQUIRED IMMUNITY

    Haruki Okamura;Hiroko Tsutsui;Shin-Ichiro Kashiwamura;Tomohiro Yoshimoto

  • Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system

    Yuichi Kondo;Tomohiro Yoshimoto;Koubun Yasuda;Shizue Futatsugi-Yumikura

  • IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

    Tomohiro Yoshimoto;Hiroko Tsutsui;Kouji Tominaga;Katsuaki Hoshino

  • IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

    H Tsutsui;K Nakanishi;K Matsui;K Higashino

  • Interleukin-18 in Health and Disease

    Koubun Yasuda;Kenji Nakanishi;Hiroko Tsutsui

  • Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice

    Yasutomo Imai;Koubun Yasuda;Yoshiko Sakaguchi;Takashi Haneda

  • Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells

    Tomohiro Yoshimoto;Haruki Okamura;Yoh Ichi Tagawa;Yoichiro Iwakura

  • IL-18 accounts for both TNF-alpha- and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice.

    H Tsutsui;K Matsui;N Kawada;Y Hyodo

Frequent Co-Authors

Hiroko Tsutsui
Hiroko Tsutsui Hyogo College of Medicine
Tomohiro Yoshimoto
Tomohiro Yoshimoto Hyogo College of Medicine
Haruki Okamura
Haruki Okamura Hyogo College of Medicine
Shizuo Akira
Shizuo Akira Osaka University
Kiyoshi Takeda
Kiyoshi Takeda Osaka University
Tadamitsu Kishimoto
Tadamitsu Kishimoto Osaka University
Toshiyuki Hamaoka
Toshiyuki Hamaoka Osaka University
Tetsuji Naka
Tetsuji Naka Kōchi University
William E. Paul
William E. Paul National Institute of Allergy and Infectious Diseases
Masashi Kurimoto
Masashi Kurimoto Okayama University

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