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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
26158
World Ranking
11672
National Ranking
832

Overview

Heike L. Pahl is affiliated with the University of Freiburg in Germany and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research focuses primarily on hematology, molecular biology, genetics, oncology, and immunology, with a notable emphasis on myeloproliferative neoplasms and related blood disorders.

The scientist's work spans a range of main topics, including:

  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Chronic Myeloid Leukemia Treatments
  • Kruppel-like factors research
  • Acute Myeloid Leukemia Research
  • Eosinophilic Disorders and Syndromes
  • Epigenetics and DNA Methylation
  • Cytokine Signaling Pathways and Interactions

Heike L. Pahl has published research in various prominent scientific journals. Frequent publication venues include:

  • Blood
  • Leukemia
  • Journal of Clinical Investigation
  • Cancer Research
  • Cancers

Recent significant papers authored or co-authored by Pahl reflect active contributions to research on inflammation, leukemogenesis, immune response, and disease severity in blood cancers. Notable publications include:

  • "Malignant JAK-signaling: at the interface of inflammation and malignant transformation" (2025, Leukemia)
  • "Kidney Dysfunction Is Associated with Thrombosis and Disease Severity in Myeloproliferative Neoplasms: Implications from the German Study Group for MPN Bioregistry" (2021, Cancers)
  • "GPRC5C drives branched-chain amino acid metabolism in leukemogenesis" (2023, Blood Advances)
  • "Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice" (2024, Journal of Clinical Investigation)
  • "Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment" (2024, Cancer Research)

Collaborative work is a notable aspect of Pahl's research, with frequent co-authors including:

  • Hans Felix Staehle
  • Steffen Koschmieder
  • Albert Gründer
  • Robert Zeiser
  • Florian H. Heidel

Through their contributions, Heike L. Pahl has established a research profile centered on deeper understanding and treatment strategies for blood cancers and related hematologic disorders. Their focus on molecular mechanisms, genetic factors, and immune system interactions continues to align with contemporary investigations in hematology and oncology.

Best Publications

  • Activators and target genes of Rel/NF-kappaB transcription factors.

    Heike L Pahl

  • Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

    E. B.-M. Traenckner;H. L. Pahl;T. Henkel;K. N. Schmidt

  • MyD88, an adapter protein involved in interleukin-1 signaling.

    Kimberly Burns;Fabio Martinon;Christoph Esslinger;Heike Pahl

  • Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

    Véronique Imbert;Rudolf A Rupec;Antonia Livolsi;Heike L Pahl

  • The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65

    G Lyss;A Knorre;T J Schmidt;H L Pahl

  • A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.

    H.L. Pahl;P.A. Baeuerle

  • Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones

    Alfonso J. Garcı́a-Piñeres;Vı́ctor Castro;Gerardo Mora;Thomas J. Schmidt

  • The ER-overload response: activation of NF-κB

    Heike L. Pahl;Patrick A. Baeuerle

  • Myeloproliferative Neoplasm (MPN) Symptom Assessment Form Total Symptom Score: Prospective International Assessment of an Abbreviated Symptom Burden Scoring System Among Patients With MPNs

    Robyn M. Emanuel;Amylou C. Dueck;Holly L. Geyer;Jean Jacques Kiladjian

  • JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms.

    Amy V Jones;Andrew Chase;Richard T Silver;David Oscier

  • Regulation of the transcription factors NF-κB and AP-1 by redox changes

    Markus Meyer;Heike L. Pahl;Patrick A. Baeuerle

  • The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

    H. L. Pahl;B. Krauss;K. Schulze-Osthoff;T. Decker

  • The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.

    H. L. Pahl;R. J. Scheibe;Dong-Er Zhang;Hui-Min Chen

  • Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action

    Peter Rüngeler;Victor Castro;Gerardo Mora;Nezhun Gören

  • Oxygen and the control of gene expression

    Heike L. Pahl;Patrick A. Baeuerle

  • Helicobacter pylori Activates Mitogen-activated Protein Kinase Cascades and Induces Expression of the Proto-oncogenes c-fos and c-jun

    Tobias Meyer-ter-Vehn;Antonello Covacci;Manfred Kist;Heike L. Pahl

  • Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB

    Guido Lyss;Thomas J. Schmidt;Irmgard Merfort;Heike L. Pahl

  • Activation of NF‐κB by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers

    Heike L. Pahl;Patrick A. Baeuerle

  • The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity.

    Hui-Min Chen;H. L. Pahl;R. J. Scheibe;Dong-Er Zhang

  • Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera.

    Snežana Temerinac;Steffen Klippel;Elisabeth Strunck;Sabine Röder

Frequent Co-Authors

Alessandro Rambaldi
Alessandro Rambaldi University of Milan
Andreas Reiter
Andreas Reiter Heidelberg University
Amylou C. Dueck
Amylou C. Dueck Mayo Clinic
Francisco Cervantes
Francisco Cervantes University of Barcelona
Harry C. Schouten
Harry C. Schouten Maastricht University
Ruben A. Mesa
Ruben A. Mesa The University of Texas Health Science Center at San Antonio
Francesco Passamonti
Francesco Passamonti University of Milan
Alessandro M. Vannucchi
Alessandro M. Vannucchi University of Florence
Claire N. Harrison
Claire N. Harrison Guy's and St Thomas' NHS Foundation Trust
Tiziano Barbui
Tiziano Barbui FROM-Fondazione per la Ricerca Ospedale di Bergamo

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