World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
82
Citations
27873
World Ranking
931
National Ranking
496

Overview

Alexander Hoffmann is affiliated with the University of California, Los Angeles in the United States. Their primary research spans immunology, molecular biology, and medicine, with focused contributions to subfields including immunology, molecular biology, oncology, cancer research, and epidemiology.

Their work concentrates on key topics such as immune response and inflammation, NF-κB signaling pathways, cytokine signaling pathways and interactions, immune cells in cancer, interferon and immune responses, T-cell and B-cell immunology, and immune cell function and interaction.

Frequent co-authors collaborating with Hoffmann include Katherine M. Sheu, Apeksha Singh, Quen J. Cheng, Adewunmi Adelaja, and Brooks Taylor.

They have published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cell Systems, Cell Reports, Proceedings of the National Academy of Sciences, and Molecular Systems Biology.

Recent papers by Hoffmann and collaborators include:

  • NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages, 2021, Science
  • Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance, 2022, Annual Review of Immunology
  • Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses, 2021, Immunity
  • Gene Regulatory Strategies that Decode the Duration of NFκB Dynamics Contribute to LPS- versus TNF-Specific Gene Expression, 2020, Cell Systems
  • Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics, 2020, Cell Reports

Best Publications

  • The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation

    Alexander Hoffmann;Andre Levchenko;Martin L. Scott;David Baltimore

  • Circuitry of nuclear factor kappaB signaling.

    Alexander Hoffmann;David Baltimore

  • Signaling via the NFκB system.

    Simon Mitchell;Jesse Vargas;Alexander Hoffmann

  • Transcriptional regulation via the NF-κB signaling module

    A Hoffmann;G Natoli;G Ghosh

  • Molecular Determinants of Crosstalk between Nuclear Receptors and Toll-like Receptors

    Sumito Ogawa;Jean Lozach;Chris Benner;Gabriel Pascual

  • Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis

    Norihiko Takeda;Ellen L. O'Dea;Andrew Doedens;Jung Whan Kim

  • A Unifying Model for the Selective Regulation of Inducible Transcription By CpG Islands and Nucleosome Remodeling

    Vladimir R. Ramirez-Carrozzi;Daniel Braas;Dev M. Bhatt;Christine S. Cheng

  • Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity

    Shannon L. Werner;Derren Barken;Alexander Hoffmann

  • A single NFκB system for both canonical and non-canonical signaling.

    Vincent Feng-Sheng Shih;Rachel Tsui;Andrew Caldwell;Alexander Hoffmann

  • Crystal structure of TFIID TATA-box binding protein

    Dimitar B. Nikolov;Shu-Hong Hu;Shu-Hong Hu;Shu-Hong Hu;Judith Lin;Judith Lin;Judith Lin;Alexander Gasch

  • A fourth IκB protein within the NF-κB signaling module

    Soumen Basak;Hana Kim;Jeffrey D. Kearns;Vinay Tergaonkar

  • One Nucleotide in a κB Site Can Determine Cofactor Specificity for NF-κB Dimers

    Thomas H. Leung;Alexander Hoffmann;David Baltimore

  • Genetic analysis of NF-κB/Rel transcription factors defines functional specificities

    Alexander Hoffmann;Thomas H. Leung;David Baltimore

  • CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

    Tomohisa Kato;Mireille Delhase;Alexander Hoffmann;Michael Karin

  • Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID).

    Alexander Hoffmann;Eric Sinn;Tohru Yamamoto;Josephine Wang

  • Accurate information transmission through dynamic biochemical signaling networks

    Jangir Selimkhanov;Brooks Taylor;Jason Yao;Anna Pilko

  • Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies

    A. Hoffmann;R.G. Roeder

  • Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators

    Jin Mo Park;Florian R. Greten;Athena Wong;Randal J. Westrick

  • Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages.

    Shomyseh Sanjabi;Alexander Hoffmann;Hsiou-Chi Liou;David Baltimore

  • Structural similarity between TAFs and the heterotetrameric core of the histone octamer.

    Xiaoling Xie;Xiaoling Xie;Tetsuro Kokubo;Tetsuro Kokubo;Steven L. Cohen;Urooj A. Mirza

Frequent Co-Authors

Gourisankar Ghosh
Gourisankar Ghosh University of California, San Diego
David Baltimore
David Baltimore California Institute of Technology
Robert G. Roeder
Robert G. Roeder Rockefeller University
Masami Horikoshi
Masami Horikoshi University of Tokyo
Stephen T. Smale
Stephen T. Smale University of California, Los Angeles
Andre Levchenko
Andre Levchenko Yale University
Stephen K. Burley
Stephen K. Burley Rutgers, The State University of New Jersey
Christopher K. Glass
Christopher K. Glass University of California, San Diego
Michael R. Yeaman
Michael R. Yeaman University of California, Los Angeles
Stephen M. Hedrick
Stephen M. Hedrick University of California, San Diego

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

If you are passionate about Molecular Biology but want flexibility in your studies, several related online degrees and career pathways can broaden your expertise. Exploring naab-accredited online architecture degrees can open doors to careers blending science and design, especially in bioengineering or research facility planning.

A bachelor in mathematics online complements molecular biology by building strong analytical and statistical skills, crucial for data analysis and research interpretation.

Those interested in creative fields might consider online graphic design programs. These skills are valuable for scientific illustration, data visualization, and developing educational resources in the life sciences.

For a broader educational background, enrolling in a program listed in the online interdisciplinary studies degree ranking affordable can help you tailor your coursework to a unique combination of subjects. This is ideal for students seeking cross-disciplinary careers that blend biology, technology, and design.

Best Scientists Citing Alexander Hoffmann

Trending Scientists

Recently Published Articles