World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
90
Citations
29944
World Ranking
735
National Ranking
397

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1982 - Fellows of the Econometric Society

Overview

Stephen T. Smale is affiliated with the University of California, Los Angeles in the United States. Their research contributions span multiple areas within biochemistry, genetics, molecular biology, immunology, and microbiology.

Their recent published papers cover topics related to immune responses, inflammation, and molecular mechanisms in cells. These papers include:

  • IL-10 constrains sphingolipid metabolism to limit inflammation (2024, Nature)
  • Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome (2020, Cell Metabolism)
  • Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins (2020, Nature Immunology)
  • The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling (2024, Immunity)
  • Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2 (2022, Acta Pharmaceutica Sinica B)

Frequent coauthors collaborating with Smale include:

  • Allison E. Daly
  • Philip O. Scumpia
  • An-Chieh Feng
  • Kevin J. Williams
  • Prabhat Kumar Purbey

They regularly publish in several prominent venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genes & Development
  • Trends in Immunology
  • Nature Immunology
  • The Journal of Immunology

Their main fields of study include biochemistry, genetics and molecular biology with 39 publications, and immunology and microbiology with 31 publications. Subfields of focus are immunology, molecular biology, cancer research, oncology, and surgery.

Key research topics covered by their work include:

  • interferon and immune responses
  • NF-κB Signaling Pathways
  • Immune Response and Inflammation
  • Genomics and Chromatin Dynamics
  • Immune Cell Function and Interaction
  • Immune cells in cancer
  • RNA Research and Splicing

Stephen T. Smale has been recognized by professional societies, including being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2019 and a Fellow of the Econometric Society in 1982.

Best Publications

  • Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.

    Hans D. Brightbill;Daniel H. Libraty;Stephan R. Krutzik;Ruey Bing Yang

  • The “initiator” as a transcription control element

    Stephen T. Smale;David Baltimore

  • The RNA polymerase II core promoter.

    Stephen T. Smale;James T. Kadonaga

  • Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

    Karen E Brown;Simon S Guest;Stephen T Smale;Kyungmin Hahm

  • DNA sequence requirements for transcriptional initiator activity in mammalian cells.

    R Javahery;A Khachi;K Lo;B Zenzie-Gregory

  • Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes

    Stephen T Smale

  • A role for Dicer in immune regulation.

    Bradley S Cobb;Arnulf Hertweck;James P Smith;Eric D. O'Connor

  • T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer.

    Bradley S Cobb;Tatyana Nesterova;Elizabeth A. Thompson;Arnulf Hertweck

  • A Unifying Model for the Selective Regulation of Inducible Transcription By CpG Islands and Nucleosome Remodeling

    Vladimir R. Ramirez-Carrozzi;Daniel Braas;Dev M. Bhatt;Christine S. Cheng

  • Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID.

    Stephen T. Smale;Martin C. Schmidt;Arnold J. Berk;David Baltimore

  • Transcriptional Regulation in Eukaryotes: Concepts, Strategies and Techniques

    Michael Carey;Stephen T.smale

  • Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions

    Dev M. Bhatt;Amy Pandya-Jones;Ann Jay Tong;Iros Barozzi

  • Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response.

    Vladimir R. Ramirez-Carrozzi;Aaron A. Nazarian;Caiyi C. Li;Sarah L. Gore

  • Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins.

    Scott E. Plevy;James H. M. Gemberling;Sang Hsu;Andrew J. Dorner

  • Selective transcription in response to an inflammatory stimulus.

    Stephen T. Smale

  • A Prominent Role for Sp1 During Lipopolysaccharide- Mediated Induction of the IL-10 Promoter in Macrophages

    Hans D. Brightbill;Scott E. Plevy;Robert L. Modlin;Stephen T. Smale

  • Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages.

    Shomyseh Sanjabi;Alexander Hoffmann;Hsiou-Chi Liou;David Baltimore

  • Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin.

    Kyungmin Hahm;Bradley S. Cobb;Aaron S. McCarty;Karen E. Brown

  • Core promoters: active contributors to combinatorial gene regulation

    Stephen T. Smale

  • Direct recognition of initiator elements by a component of the transcription factor IID complex.

    J Kaufmann;S T Smale

Frequent Co-Authors

Michael Carey
Michael Carey University of California, Los Angeles
Craig L. Peterson
Craig L. Peterson University of Massachusetts Chan Medical School
Matthias Merkenschlager
Matthias Merkenschlager Imperial College London
Amanda G. Fisher
Amanda G. Fisher University of Oxford
Peter Tontonoz
Peter Tontonoz University of California, Los Angeles
Gioacchino Natoli
Gioacchino Natoli European Institute of Oncology
Alexander Hoffmann
Alexander Hoffmann University of California, Los Angeles
Irving L. Weissman
Irving L. Weissman Stanford University
Robert L. Modlin
Robert L. Modlin University of California, Los Angeles
Kenneth S. Zaret
Kenneth S. Zaret University of Pennsylvania

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a degree in Molecular Biology opens up a wide range of academic and professional options. If you’re considering online study, there are many related fields to boost your expertise and career prospects. For example, pursuing an online interdisciplinary studies degree career outcomes can prepare you for diverse roles across science and healthcare industries by combining biology with other disciplines.

For those interested in history’s role in biological research or science communication, the best online history masters programs offer a flexible path to deepen your academic credentials. Similarly, understanding the organizational side of scientific resources is possible with a library science degree, which can lead to careers managing research archives or digital databases.

If you’re drawn to healthcare and communication, asha approved slp programs online provide specialized training in speech-language pathology, meeting professional standards while allowing flexibility. Each of these online degrees opens new career pathways related to molecular biology, allowing students to customize their education and future opportunities.

Best Scientists Citing Stephen T. Smale

Trending Scientists

Recently Published Articles