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Biology and Biochemistry

D-Index
62
Citations
20281
World Ranking
10567
National Ranking
4590

Overview

Jan Lammerding is affiliated with Cornell University in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with a total of 143 publications. Their research primarily focuses on molecular biology, cell biology, oncology, biomedical engineering, and biophysics.

The scientific topics addressed in Lammerding's work include nuclear structure and function, RNA research and splicing, cellular mechanics and interactions, microtubule and mitosis dynamics, genomics and chromatin dynamics, DNA repair mechanisms, and 3D printing in biomedical research.

Some of the recent publications authored by Lammerding and their colleagues are:

  • Mechanics and functional consequences of nuclear deformations (2022), published in Nature Reviews Molecular Cell Biology
  • Nuclear Deformation Causes DNA Damage by Increasing Replication Stress (2020), published in Current Biology
  • Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer (2022), published in Oncogene
  • Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue (2021), published in Nature Biomedical Engineering
  • Confined migration induces heterochromatin formation and alters chromatin accessibility (2022), published in iScience

Lammerding has frequently published in journals such as bioRxiv (Cold Spring Harbor Laboratory), Trends in Cell Biology, Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Journal of Cell Science, and iScience.

Collaborations feature several frequent co-authors:

  • Jacob Odell
  • Noam Zuela-Sopilniak
  • Matthew J. Paszek
  • Pragya Shah
  • Richa Agrawal

This combination of research topics and collaborations reflects a focus on the mechanics and dynamics of cellular processes at the molecular and structural level, including nuclear function and cellular migration, which have implications for understanding disease mechanisms, particularly in oncology and regenerative medicine.

Best Publications

  • Mechanotransduction gone awry.

    Diana E. Jaalouk;Jan Lammerding

  • Chromosomal instability drives metastasis through a cytosolic DNA response.

    Samuel F. Bakhoum;Samuel F. Bakhoum;Bryan Ngo;Ashley M. Laughney;Julie Ann Cavallo;Julie Ann Cavallo

  • Nuclear envelope rupture and repair during cancer cell migration

    Celine M. Denais;Rachel M. Gilbert;Philipp Isermann;Alexandra L. McGregor

  • Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction

    Jan Lammerding;P. Christian Schulze;Tomosaburo Takahashi;Serguei Kozlov

  • Nuclear Shape, Mechanics, and Mechanotransduction

    Kris Noel Dahl;Alexandre J.S. Ribeiro;Jan Lammerding

  • Lamins A and C but not lamin B1 regulate nuclear mechanics

    Jan Lammerding;Loren G. Fong;Julie Y. Ji;Karen Reue;Karen Reue

  • The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

    Maria L. Lombardi;Diana E. Jaalouk;Catherine M. Shanahan;Brian Burke

  • Nuclear mechanics during cell migration

    Peter Friedl;Katarina Wolf;Jan Lammerding

  • Emerging views of the nucleus as a cellular mechanosensor

    Tyler J Kirby;Jan Lammerding

  • Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics

    Chin Yee Ho;Diana E. Jaalouk;Diana E. Jaalouk;Maria K. Vartiainen;Jan Lammerding;Jan Lammerding

  • Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells

    Jan Lammerding;Janet Hsiao;P. Christian Schulze;Serguei Kozlov

  • Nuclear Mechanics and Mechanotransduction in Health and Disease

    Philipp Isermann;Jan Lammerding

  • Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions *

    Amy C. Rowat;Amy C. Rowat;Amy C. Rowat;Diana E. Jaalouk E. Jaalouk;Monika Zwerger;W. Lloyd Ung

  • Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

    Patricia M. Davidson;Celine Denais;Maya C. Bakshi;Jan Lammerding

  • Prelamin A and lamin A appear to be dispensable in the nuclear lamina

    Loren G. Fong;Jennifer K. Ng;Jan Lammerding;Timothy A. Vickers

  • Broken nuclei--lamins, nuclear mechanics, and disease.

    Patricia M. Davidson;Jan Lammerding

  • A three-dimensional viscoelastic model for cell deformation with experimental verification

    Hélène Karcher;Jan Lammerding;Hayden Huang;Richard T. Lee

  • Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors

    Valerie L. R. M. Verstraeten;Julie Y. Ji;Kiersten S. Cummings;Richard T. Lee

  • Mechanical Properties of the Cell Nucleus and the Effect of Emerin Deficiency

    A.C. Rowat;J. Lammerding;John Hjort Ipsen

  • Mechanotransduction in cardiac myocytes.

    Jan Lammerding;Roger D. Kamm;Richard T. Lee;Richard T. Lee

Frequent Co-Authors

Richard T. Lee
Richard T. Lee Harvard University
Patricia M. Davidson
Patricia M. Davidson Johns Hopkins University
Colin L. Stewart
Colin L. Stewart Agency for Science, Technology and Research
Loren G. Fong
Loren G. Fong University of California, Los Angeles
Stephen G. Young
Stephen G. Young University of California, Los Angeles
Peter Friedl
Peter Friedl Radboud University Medical Center
Harald Herrmann
Harald Herrmann German Cancer Research Center
Jukka Westermarck
Jukka Westermarck Åbo Akademi University
Gisèle Bonne
Gisèle Bonne Université Paris Cité

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