World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
13650
World Ranking
9244
National Ranking
4090

Research.com Recognitions

  • 2017 - Hellman Fellow

Overview

Michelle A. Digman is affiliated with the University of California, Irvine in the United States. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with a total of 108 publications in this area. Within these fields, they have contributed extensively to Molecular Biology, Biophysics, Biomedical Engineering, Cancer Research, and Oncology.

Their work covers several specific research topics including:

  • Advanced Fluorescence Microscopy Techniques
  • Cell Image Analysis Techniques
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Mitochondrial Function and Pathology
  • Metabolomics and Mass Spectrometry Studies
  • Cancer Cells and Metastasis
  • Bioluminescence and Chemiluminescence Research

Michelle A. Digman has published numerous papers across various scientific journals and venues. Their frequent publication outlets include the Biophysical Journal, bioRxiv hosted by Cold Spring Harbor Laboratory, Nature Methods, Nature Cell Biology, and ACS Photonics.

Recent papers authored or co-authored by Digman include:

  • "Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing," 2020, Nature Cell Biology
  • "UTX condensation underlies its tumour-suppressive activity," 2021, Nature
  • "Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis," 2020, Nature Cell Biology
  • "Automated segmentation and tracking of mitochondria in live-cell time-lapse images," 2021, Nature Methods
  • "Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing," 2024, Nature Communications

The scientist frequently collaborates with several researchers. Notable co-authors include Lorenzo Scipioni, Enrico Gratton, Giulia Tedeschi, Francesco Palomba, and Austin E.Y.T. Lefebvre.

Among their achievements, Michelle A. Digman was awarded the Hellman Fellow in 2017.

Best Publications

  • The Phasor Approach to Fluorescence Lifetime Imaging Analysis

    Michelle A. Digman;Valeria R. Caiolfa;Moreno Zamai;Enrico Gratton

  • Measuring fast dynamics in solutions and cells with a laser scanning microscope.

    Michelle A. Digman;Claire M. Brown;Parijat Sengupta;Paul W. Wiseman

  • Mapping the number of molecules and brightness in the laser scanning microscope.

    Michelle A. Digman;Rooshin Dalal;Alan F. Horwitz;Enrico Gratton

  • Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue

    Chiara Stringari;Amanda Cinquin;Olivier Cinquin;Michelle A. Digman

  • Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

    Kira T Pate;Chiara Stringari;Stephanie Sprowl-Tanio;Kehui Wang

  • Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

    Claire C. Chen;Linan Liu;Fengxia Ma;Fengxia Ma;Chi W. Wong

  • Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection

    Dong-Ku Kang;M. Monsur Ali;Kaixiang Zhang;Susan S. Huang

  • Fluctuation correlation spectroscopy with a laser-scanning microscope: exploiting the hidden time structure.

    Michelle A. Digman;Parijat Sengupta;Paul W. Wiseman;Claire M. Brown

  • Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing.

    Ryan T. Davis;Kerrigan Blake;Dennis Ma;Mari B. Ishak Gabra

  • Lessons in Fluctuation Correlation Spectroscopy

    Michelle A. Digman;Enrico Gratton

  • Raster image correlation spectroscopy (RICS) for measuring fast protein dynamics and concentrations with a commercial laser scanning confocal microscope.

    C. M. Brown;R. B. Dalal;B. Hebert;M. A. Digman

  • Stoichiometry of molecular complexes at adhesions in living cells

    Michelle A. Digman;Paul W. Wiseman;Colin Choi;Alan R. Horwitz

  • Raster image correlation spectroscopy in live cells

    Molly J Rossow;Jennifer M Sasaki;Michelle A Digman;Enrico Gratton

  • PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells

    Seong M. Kim;Tricia T. Nguyen;Archna Ravi;Peter Kubiniok

  • Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains.

    Bharath Ananthanarayanan;Robert V. Stahelin;Michelle A. Digman;Wonhwa Cho

  • Paxillin Dynamics Measured during Adhesion Assembly and Disassembly by Correlation Spectroscopy

    Michelle A. Digman;Claire M. Brown;Alan R. Horwitz;William W. Mantulin

  • Free Extracellular Diffusion Creates the Dpp Morphogen Gradient of the Drosophila Wing Disc

    Shaohua Zhou;Wing-Cheong Lo;Jeffrey L. Suhalim;Michelle A. Digman

  • Imaging barriers to diffusion by pair correlation functions.

    Michelle A. Digman;Enrico Gratton

  • Diacylglycerol-induced membrane targeting and activation of protein kinase Cepsilon: mechanistic differences between protein kinases Cdelta and Cepsilon.

    Robert V. Stahelin;Michelle A. Digman;Michelle A. Digman;Martina Medkova;Bharath Ananthanarayanan

  • Heparan Sulfate Acts as a Bone Morphogenetic Protein Coreceptor by Facilitating Ligand-induced Receptor Hetero-oligomerization

    Wan-Jong Kuo;Michelle A. Digman;Arthur D. Lander

Frequent Co-Authors

Enrico Gratton
Enrico Gratton University of California, Irvine
Robert V. Stahelin
Robert V. Stahelin Purdue University West Lafayette
Robert M. Hoffman
Robert M. Hoffman AntiCancer (United States)
Daniela Pozzi
Daniela Pozzi Sapienza University of Rome
Abraham P. Lee
Abraham P. Lee University of California, Irvine
Kyoko Yokomori
Kyoko Yokomori University of California, Irvine
Wonhwa Cho
Wonhwa Cho University of Illinois at Chicago
Albert F. Yee
Albert F. Yee University of California, Irvine
Moshe Levi
Moshe Levi Georgetown University
Joseph P. Albanesi
Joseph P. Albanesi The University of Texas Southwestern Medical Center

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