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Ernest Fraenkel

Ernest Fraenkel

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
24494
World Ranking
11102
National Ranking
4803

Overview

Ernest Fraenkel is a researcher affiliated with MIT in the United States, specializing in the fields of Biochemistry, Genetics, and Molecular Biology as well as Medicine. Their work spans multiple subfields including Molecular Biology, Neurology, Genetics, Cellular and Molecular Neuroscience, and Immunology.

Their research focuses on various key scientific topics such as Amyotrophic Lateral Sclerosis (ALS) Research, Neurogenetic and Muscular Disorders Research, Genetic Neurodegenerative Diseases, Single-cell and Spatial Transcriptomics, RNA Research and Splicing, Bioinformatics and Genomic Networks, and Mitochondrial Function and Pathology.

Their recent publications include the following papers:

  • "TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A" (2022), published in Nature
  • "Dictionary of immune responses to cytokines at single-cell resolution" (2023), published in Nature
  • "Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines" (2022), published in Nature Neuroscience
  • "Genome-scale screens identify factors regulating tumor cell responses to natural killer cells" (2021), published in Nature Genetics
  • "A Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules" (2020), published in Scientific Reports

Frequently collaborating with peers, Fraenkel has co-authored numerous papers with the following researchers:

  • Leslie M. Thompson (22 collaborations)
  • James D. Berry (21 collaborations)
  • Steven Finkbeiner (17 collaborations)
  • Dhruv Sareen (15 collaborations)
  • Hemali Phatnani (13 collaborations)

Fraenkel's work is commonly published in notable scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory) - 21 publications
  • Nature Communications - 7 publications
  • arXiv (Cornell University) - 5 publications
  • Nature - 3 publications
  • Nature Neuroscience - 2 publications

Best Publications

  • Transcriptional Regulatory Networks in Saccharomyces cerevisiae

    Tong Ihn Lee;Nicola J. Rinaldi;François Robert;Duncan T. Odom

  • Transcriptional regulatory code of a eukaryotic genome

    Christopher T. Harbison;D. Benjamin Gordon;Tong Ihn Lee;Nicola J. Rinaldi

  • Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

    Duncan T. Odom;Nora Zizlsperger;D. Benjamin Gordon;George W. Bell

  • The whole-genome landscape of medulloblastoma subtypes

    Paul A. Northcott;Paul A. Northcott;Ivo Buchhalter;Ivo Buchhalter;A. Sorana Morrissy;Volker Hovestadt

  • Foxp3 occupancy and regulation of key target genes during T-cell stimulation

    Alexander Marson;Karsten Kretschmer;Garrett M. Frampton;Elizabeth S. Jacobsen

  • An improved map of conserved regulatory sites for Saccharomyces cerevisiae

    Kenzie D MacIsaac;Ting Wang;D Benjamin Gordon;D Benjamin Gordon;David K Gifford

  • Computational discovery of gene modules and regulatory networks.

    Ziv Bar-Joseph;Georg K Gerber;Tong Ihn Lee;Nicola J Rinaldi

  • HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

    Marc L. Mendillo;Sandro Santagata;Sandro Santagata;Martina Koeva;George W. Bell

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Tissue-specific transcriptional regulation has diverged significantly between human and mouse.

    Duncan T Odom;Robin D Dowell;Elizabeth S Jacobsen;William Gordon

  • The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

    Alexandra B. Keenan;Sherry L. Jenkins;Kathleen M. Jagodnik;Simon Koplev

  • Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F–DP

    Ning Zheng;Ernest Fraenkel;Carl O. Pabo;Nikola P. Pavletich

  • Insights into GATA-1 Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis

    Ming Yu;Laura Riva;Huafeng Xie;Yocheved Schindler

  • Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

    Esti Yeger-Lotem;Laura Riva;Linhui Julie Su;Aaron D Gitler;Aaron D Gitler

  • Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors

    Ming Yu;Tali Mazor;Hui Huang;Hsuan-Ting Huang

  • Practical Strategies for Discovering Regulatory DNA Sequence Motifs

    Kenzie D MacIsaac;Ernest Fraenkel

  • Core transcriptional regulatory circuitry in human hepatocytes

    Duncan T Odom;Robin D Dowell;Elizabeth S Jacobsen;Lena Nekludova

  • Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM

    Alan S. L. Wong;Gigi C. G. Choi;Cheryl H. Cui;Gabriela Pregernig

  • Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

    Ryan G. Lim;Chris Quan;Andrea M. Reyes-Ortiz;Sarah E. Lutz

  • Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Nicola Ticozzi

Frequent Co-Authors

Leslie M. Thompson
Leslie M. Thompson University of California, Irvine
Clive N. Svendsen
Clive N. Svendsen Cedars-Sinai Medical Center
Alan B. Cantor
Alan B. Cantor Harvard University
Scott L. Pomeroy
Scott L. Pomeroy Boston Children's Hospital
Roger J. Davis
Roger J. Davis University of Massachusetts Chan Medical School
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco

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