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Biology and Biochemistry

D-Index
58
Citations
9441
World Ranking
13427
National Ranking
955

Overview

Rudolf E. Leube is affiliated with RWTH Aachen University in Germany and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans various subfields, including cell biology, molecular biology, cardiology and cardiovascular medicine, aging, and immunology.

The scientist has explored several main topics throughout their career. These include skin and cellular biology research, cellular mechanics and interactions, genetics, aging and longevity in model organisms, cardiovascular effects of exercise, reproductive system and pregnancy, endometriosis research and treatment, and circadian rhythm and melatonin.

Rudolf E. Leube has published work in numerous scientific journals, with frequent appearances in the following publication venues:

  • Cells
  • International Journal of Molecular Sciences
  • Scientific Reports
  • Frontiers in Cell and Developmental Biology
  • bioRxiv (Cold Spring Harbor Laboratory)

Recent papers by Leube include the following:

  • "Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy," 2020, Basic Research in Cardiology
  • "Hemidesmosome-Related Keratin Filament Bundling and Nucleation," 2021, International Journal of Molecular Sciences
  • "How Mechanical Forces Change the Human Endometrium during the Menstrual Cycle in Preparation for Embryo Implantation," 2021, Cells
  • "Intestinal intermediate filament polypeptides in C. elegans: Common and isotype-specific contributions to intestinal ultrastructure and function," 2020, Scientific Reports
  • "Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy," 2020, JCI Insight

Leube collaborates regularly with several coauthors, including Nicole Schwarz, Reinhard Windoffer, Sebastian Kant, Florian Geisler, and Jacopo Di Russo. The count of publications with these coauthors ranges from five to nine joint contributions each, reflecting collaborative efforts in their research areas.

Best Publications

  • Structural and regulatory functions of keratins

    Thomas M. Magin;Preethi Vijayaraj;Rudolf E. Leube

  • Detection of behavioral alterations and learning deficits in mice lacking synaptophysin.

    U. Schmitt;N. Tanimoto;M. Seeliger;F. Schaeffel

  • Keratins as the main component for the mechanical integrity of keratinocytes

    Lena Ramms;Gloria Fabris;Reinhard Windoffer;Nicole Schwarz

  • Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage

    Sergey M. Troyanovsky;Leonid G. Eshkind;Regina B. Troyanovsky;Rudolf E. Leube

  • Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA.

    R. E. Leube;P. Kaiser;A. Seiter;R. Zimbelmann

  • Structure and function of desmosomes.

    Bastian Holthöfer;Reinhard Windoffer;Sergey Troyanovsky;Rudolf E. Leube

  • Expression of simple epithelial type cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ.

    F X Bosch;R E Leube;T Achtstätter;R Moll

  • Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia

    Reinhard Windoffer;Michael Beil;Thomas M. Magin;Rudolf E. Leube

  • Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells.

    Leonid Eshkind;Qi Tian;Ansgar Schmidt;Werner W. Franke

  • Molecular characterization and expression of the stratification-related cytokeratins 4 and 15.

    R. E. Leube;B. L. Bader;F. X. Bosch;R. Zimbelmann

  • Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage

    Sergey M. Troyanovsky;Regina B. Troyanovsky;Regina B. Troyanovsky;Leonid G. Eshkind;Vladimir A. Krutovskikh

  • Characterization of the human gene encoding cytokeratin 17 and its expression pattern.

    S. M. Troyanovsky;R. E. Leube;Werner W. Franke

  • Mice lacking synaptophysin reproduce and form typical synaptic vesicles.

    Leonid G. Eshkind;Rudolf E. Leube

  • Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation.

    Sergey M. Troyanovsky;Regina B. Troyanovsky;Regina B. Troyanovsky;Leonid G. Eshkind;Rudolf E. Leube

  • Keratins control intercellular adhesion involving PKC-α–mediated desmoplakin phosphorylation

    Cornelia Kröger;Fanny Loschke;Nicole Schwarz;Reinhard Windoffer

  • Cytokeratin expression in simple epithelia: III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ

    Rudolf E. Leube;Franx X. Bosch;Valentino Romano;Ralf Zimbelmann

  • Synaptophysin Is Required for Synaptobrevin Retrieval during Synaptic Vesicle Endocytosis

    Sarah L. Gordon;Rudolf E. Leube;Michael A. Cousin

  • Keratins Regulate Protein Biosynthesis Through Localization of GLUT1 and -3 Upstream of AMP Kinase and Raptor

    Preethi Vijayaraj;Preethi Vijayaraj;Cornelia Kröger;Ursula Reuter;Reinhard Windoffer

  • The binding of plakoglobin to desmosomal cadherins: patterns of binding sites and topogenic potential.

    Nikolai A. Chitaev;Rudolf E. Leube;Regina B. Troyanovsky;Leonid G. Eshkind

  • Topogenesis and sorting of synaptophysin: Synthesis of a synaptic vesicle protein from a gene transfected into nonneuroendocrine cells

    Rudolf E. Leube;Bertram Wiedenmann;Werner W. Franke

Frequent Co-Authors

Thomas M. Magin
Thomas M. Magin Leipzig University
Werner W. Franke
Werner W. Franke German Cancer Research Center
Til Aach
Til Aach RWTH Aachen University
Nikolas K. Haass
Nikolas K. Haass University of Queensland
Erik M. Jorgensen
Erik M. Jorgensen University of Utah
Christian Trautwein
Christian Trautwein RWTH Aachen University
Jens Waschke
Jens Waschke Ludwig-Maximilians-Universität München
Joachim Jankowski
Joachim Jankowski RWTH Aachen University
Anna Akhmanova
Anna Akhmanova Utrecht University
Dennis R. Roop
Dennis R. Roop University of Colorado Anschutz Medical Campus

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