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Immunology

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56
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17826
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National Ranking
321

Overview

Rainer Doffinger is a researcher affiliated with the University of Cambridge in the United Kingdom. Their scientific work primarily centers on the field of Medicine, with a particular focus on Infectious Diseases, Immunology, Neurology, Genetics, and Molecular Biology. The main topics in their research portfolio include SARS-CoV-2 and COVID-19 research, COVID-19 clinical research studies, immunodeficiency and autoimmune disorders, long-term effects of COVID-19, T-cell and B-cell immunology, SARS-CoV-2 detection and testing, and immune cell function and interaction.

Doffinger has contributed to numerous publications that address various aspects of SARS-CoV-2 and immune system responses. Notable recent papers include:

  • A thermostable, closed SARS-CoV-2 spike protein trimer (2020, Nature Structural & Molecular Biology)
  • Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease (2021, Immunity)
  • Neutralising antibodies in Spike mediated SARS-CoV-2 adaptation (2020, bioRxiv (Cold Spring Harbor Laboratory))
  • SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies (2021, bioRxiv (Cold Spring Harbor Laboratory))
  • Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report (2020, Nature Communications)

The frequent publication venues for Doffinger's work highlight involvement in both preprint and peer-reviewed settings, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Immunology
  • Research Square (Research Square)
  • Nature Communications
  • Frontiers in Immunology

Collaboration forms a significant part of Doffinger's research activities. Frequent co-authors include John R. Bradley, Lourdes Ceron-Gutierrez, Kenneth G. C. Smith, Ravindra K. Gupta, and Nathalie Kingston, reflecting ongoing partnerships within the immunology and infectious disease research communities.

Best Publications

  • Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

    Frédéric Altare;Anne Durandy;David Lammas;Jean-François Emile

  • SARS-CoV-2 evolution during treatment of chronic infection.

    Steven A. Kemp;Dami A. Collier;Dami A. Collier;Rawlings P. Datir;Isabella A. T. M. Ferreira

  • X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling.

    Rainer Döffinger;Asma Smahi;Christine Bessia;Frédéric Geissmann

  • A robust model for read count data in exome sequencing experiments and implications for copy number variant calling

    Vincent Plagnol;James Curtis;Michael Epstein;Kin Y. Mok

  • Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.

    Dami A Collier;Dami A Collier;Isabella A T M Ferreira;Prasanti Kotagiri;Rawlings P Datir;Rawlings P Datir

  • A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

    Emmanuelle Jouanguy;Salma Lamhamedi-Cherradi;David Lammas;Susan E. Dorman

  • Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

    Ivan Angulo;Oscar Vadas;Fabien Garçon;Edward Banham-Hall

  • Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

    Anne Puel;Anne Puel;Rainer Döffinger;Angels Natividad;Angels Natividad;Maya Chrabieh;Maya Chrabieh

  • IRF8 mutations and human dendritic-cell immunodeficiency.

    Sophie Hambleton;Sandra Salem;Jacinta Bustamante;Venetia Bigley

  • Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.

    Dami A. Collier;Dami A. Collier;Anna De Marco;Isabella A. T. M. Ferreira;Bo Meng

  • Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.

    F Altare;D Lammas;P Revy;E Jouanguy

  • Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

    Capucine Picard;Capucine Picard;Horst Von Bernuth;Horst Von Bernuth;Horst Von Bernuth;Pegah Ghandil;Pegah Ghandil;Pegah Ghandil;Maya Chrabieh;Maya Chrabieh

  • IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.

    Emmanuelle Jouanguy;Rainer Döffinger;Stéphanie Dupuis;Annaïck Pallier

  • Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.

    Tanya I Coulter;Anita Chandra;Chris M Bacon;Judith Babar

  • Revisiting Human IL-12Rβ1 Deficiency: A Survey of 141 Patients From 30 Countries

    Ludovic de Beaucoudrey;Arina Samarina;Arina Samarina;Arina Samarina;Jacinta Bustamante;Jacinta Bustamante;Aurélie Cobat;Aurélie Cobat

  • A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

    Gilles Courtois;Asma Smahi;Janine Reichenbach;Rainer Döffinger

  • The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

    Bing He;Raul Santamaria;Weifeng Xu;Montserrat Cols

  • The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency

    Venetia Bigley;Muzlifah Haniffa;Sergei Doulatov;Xiao-Nong Wang

  • The NF-κB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes

    Asma Smahi;Gilles Courtois;Smail Hadj Rabia;Rainer Döffinger

  • Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.

    Laura Bergamaschi;Federica Mescia;Lorinda Turner;Aimee L. Hanson

  • A thermostable, closed SARS-CoV-2 spike protein trimer.

    Xiaoli Xiong;Kun Qu;Katarzyna A. Ciazynska;Myra Hosmillo

  • Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

    Erik Schoenmakers;Maura Agostini;Catherine Mitchell;Nadia Schoenmakers

  • Autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity.

    Rainer Döffinger;Matthew R. Helbert;Gabriela Barcenas-Morales;Kun Yang

  • Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.

    Emma M. Haapaniemi;Meri Kaustio;Hanna L. M. Rajala;Arjan J. van Adrichem

  • IRAK-4-and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

    Isabelle Isnardi;Yen Shing Ng;Iva Srdanovic;Roja Motaghedi

  • Human interferon-gamma-mediated immunity is a genetically controlled continuous trait that determines the outcome of mycobacterial invasion.

    Stéphanie Dupuis;Rainer Döffinger;Capucine Picard;Claire Fieschi

Frequent Co-Authors

Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Mario Abinun
Mario Abinun Newcastle University
Siobhan O. Burns
Siobhan O. Burns University College London
Kenneth G. C. Smith
Kenneth G. C. Smith Walter and Eliza Hall Institute of Medical Research
Sinisa Savic
Sinisa Savic University of Leeds
Andrew J. Cant
Andrew J. Cant Newcastle University
Adrian J. Thrasher
Adrian J. Thrasher University College London
Bodo Grimbacher
Bodo Grimbacher University of Freiburg
Ian Goodfellow
Ian Goodfellow University of Cambridge
Capucine Picard
Capucine Picard Université Paris Cité

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