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Biology and Biochemistry

D-Index
52
Citations
11007
World Ranking
16596
National Ranking
1309

Overview

Rachel Toth is affiliated with the University of Dundee in the United Kingdom and has a research focus primarily within Biochemistry, Genetics, and Molecular Biology, amassing 97 publications in this broad field. Their work spans several subfields including Molecular Biology, Genetics, Epidemiology, Cell Biology, and Oncology.

Their research topics include:

  • Ubiquitin and proteasome pathways
  • Autophagy in Disease and Therapy
  • Genetics and Neurodevelopmental Disorders
  • Mitochondrial Function and Pathology
  • DNA Repair Mechanisms
  • Parkinson's Disease Mechanisms and Treatments
  • PARP inhibition in cancer therapy

Rachel Toth has contributed to a range of recent scientific papers such as:

  • "Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies," 2021, published in PLoS ONE
  • "Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1," 2021, published in Science Advances
  • "Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling," 2020, published in Developmental Cell
  • "Structural basis of FANCD2 deubiquitination by USP1−UAF1," 2021, published in Nature Structural & Molecular Biology
  • "CDKL5 kinase controls transcription-coupled responses to DNA damage," 2021, published in The EMBO Journal

Frequent co-authors of Rachel Toth include:

  • Thomas Macartney (17 joint publications)
  • John Rouse (15 joint publications)
  • Houjiang Zhou (14 joint publications)
  • Thomas Carroll (11 joint publications)
  • Miratul M. K. Muqit (10 joint publications)

Their publications appear predominantly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory) - 17 publications
  • Zenodo (CERN European Organization for Nuclear Research) - 8 publications
  • Life Science Alliance - 4 publications
  • Scientific Reports - 4 publications
  • Science Advances - 3 publications

Best Publications

  • LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

    Jose M Lizcano;Olga Göransson;Rachel Toth;Maria Deak

  • Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

    David E. Gordon;Joseph Hiatt;Mehdi Bouhaddou;Veronica V. Rezelj

  • Loss of iron triggers PINK1/Parkin‐independent mitophagy

    George F G Allen;Rachel Toth;John James;Ian G Ganley

  • Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.

    Ivan M. Muñoz;Karolina Hain;Anne-Cécile Déclais;Mary Gardiner

  • Bioinformatic and experimental survey of 14-3-3-binding sites

    Catherine Johnson;Sandra Crowther;Margaret J. Stafford;David G. Campbell

  • The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

    Olga Ananieva;Joanne Darragh;Claus Johansen;Julia M Carr

  • PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A–SIK–CRTC3 Pathway

    Kirsty F. MacKenzie;Kristopher Clark;Shaista Naqvi;Victoria A. McGuire

  • Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.

    Shuai Chen;Jane Murphy;Rachel Toth;David G. Campbell

  • Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

    Andrew Macdonald;David G Campbell;Rachel Toth;Hilary McLauchlan

  • A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.

    Suzannah J. Rihn;Andreas Merits;Siddharth Bakshi;Matthew L. Turnbull

  • Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

    Kathryn M. Geraghty;Shuai Chen;Jean E. Harthill;Adel F. Ibrahim

  • 14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides

    Fábio Madeira;Michele Tinti;Gavuthami Murugesan;Emily Berrett

  • Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.

    Atul Kumar;Jacob D Aguirre;Tara E C Condos;R Julio Martinez-Torres

  • Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate

    Mahaboobi Jaleel;Andrew McBride;Jose M. Lizcano;Maria Deak

  • mTOR activates the VPS34–UVRAG complex to regulate autolysosomal tubulation and cell survival

    Michael J. Munson;George F. G. Allen;Rachel Toth;David G. Campbell

  • K29-Selective Ubiquitin Binding Domain Reveals Structural Basis of Specificity and Heterotypic Nature of K29 Polyubiquitin

    Yosua Adi Kristariyanto;Syed Arif Abdul Rehman;David G. Campbell;Nicholas A. Morrice

  • Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

    Sambit K. Nanda;Ram K.C. Venigalla;Alban Ordureau;Janet C. Patterson-Kane

  • Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.

    Dennis Castor;Nidhi Nair;Anne-Cécile Déclais;Christophe Lachaud

  • 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

    Abdallah K Al-Hakim;Olga Göransson;Maria Deak;Rachel Toth

  • MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

    Beatrice M Filippi;Paola de los Heros;Youcef Mehellou;Iva Navratilova

Frequent Co-Authors

Carol MacKintosh
Carol MacKintosh University of Dundee
J. Simon C. Arthur
J. Simon C. Arthur University of Dundee
David G. Campbell
David G. Campbell University of Adelaide
Alan R. Prescott
Alan R. Prescott University of Dundee
Maria Deak
Maria Deak University of Dundee
Dario R. Alessi
Dario R. Alessi University of Dundee
Axel Knebel
Axel Knebel University of Dundee
Lars Iversen
Lars Iversen Aarhus University Hospital
D. Grahame Hardie
D. Grahame Hardie University of Dundee
Philip Cohen
Philip Cohen University of Dundee

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