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D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
14097
World Ranking
13664
National Ranking
1065

Overview

Carol MacKintosh is affiliated with the University of Dundee in the United Kingdom. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology and cardiovascular medicine.

The primary fields of study in MacKintosh's work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields targeted in their research comprise:

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Epidemiology
  • Surgery
  • Genetics

Their main research topics address:

  • 14-3-3 protein interactions
  • Metabolism, Diabetes, and Cancer
  • Ubiquitin and proteasome pathways
  • Autophagy in Disease and Therapy
  • Pancreatic function and diabetes
  • Cardiovascular Function and Risk Factors
  • Cardiomyopathy and Myosin Studies

MacKintosh has contributed to several recent papers, which highlight diverse aspects of molecular signaling and disease mechanisms:

  • A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis, 2020, Nature Communications
  • Opposing roles for AMPK in regulating distinct mitophagy pathways, 2024, Molecular Cell
  • Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators, 2021, Journal of Biological Chemistry
  • Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells, 2022, Biochemical Journal
  • Publisher's Note: ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase, 2022, Journal of Cell Science

Frequently collaborating with MacKintosh are several researchers, including:

  • Marianna Longo
  • Alan R. Prescott
  • Rachel Toth
  • David G. Campbell
  • Aniketh Bishnu

The venues where MacKintosh's work is often published reflect their research scope and impact. These include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Molecular Cell
  • Nature Communications
  • Journal of Biological Chemistry
  • Biochemical Journal

Best Publications

  • Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants.

    Carol MacKintosh;Kenneth A. Beattie;Susanne Klumpp;Philip Cohen

  • Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.

    J. Liu;M. W. Albers;T. J. Wandless;S. Luan

  • Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

    Carol Mackintosh

  • 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.

    Mercedes Pozuelo Rubio;Kathryn M Geraghty;Barry H C Wong;Nicola T Wood

  • Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1

    Carina I. Holmberg;Ville Hietakangas;Andrey Mikhailov;Jouni O. Rantanen

  • Bioinformatic and experimental survey of 14-3-3-binding sites

    Catherine Johnson;Sandra Crowther;Margaret J. Stafford;David G. Campbell

  • The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.

    Robert W. MacKintosh;Kevin N Dalby;David G. Campbell;Patricia T.W. Cohen

  • Inhibitors of protein kinases and phosphatases

    Carol MacKintosh;Robert W. MacKintosh

  • AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours.

    Fiona A. Ross;Carol MacKintosh;D. Grahame Hardie

  • Phosphorylation-dependent interactions between enzymes of plant metabolism and 14-3-3 proteins.

    Greg Moorhead;Pauline Douglas;Valerie Cotelle;Jean Harthill

  • Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccin

    Greg Moorhead;Pauline Douglas;Nick Morrice;Marie Scarabel

  • PRAS40 Is a Target for Mammalian Target of Rapamycin Complex 1 and Is Required for Signaling Downstream of This Complex

    Bruno D. Fonseca;Ewan M. Smith;Ewan M. Smith;Vivian H.-Y. Lee;Carol MacKintosh

  • Modulators of 14-3-3 Protein-Protein Interactions

    Loes M. Stevers;Eline Sijbesma;Maurizio Botta;Carol MacKintosh

  • Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A.

    Carol MacKintosh;Susanne Klumpp

  • 14-3-3s regulate global cleavage of their diverse binding partners in sugar-starved Arabidopsis cells

    Valérie Cotelle;Sarah E.M. Meek;Fiona Provan;Fiona C. Milne

  • Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.

    Shuai Chen;Jane Murphy;Rachel Toth;David G. Campbell

  • Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

    Kathryn M. Geraghty;Shuai Chen;Jean E. Harthill;Adel F. Ibrahim

  • 14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides

    Fábio Madeira;Michele Tinti;Gavuthami Murugesan;Emily Berrett

  • Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose.

    Jean E. Harthill;Sarah E. M. Meek;Nick Morrice;Mark W. Peggie

  • Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues.

    Yue-Ming Li;Carol Mackintosh;John E. Casida

Frequent Co-Authors

Rachel Toth
Rachel Toth University of Dundee
David G. Campbell
David G. Campbell University of Adelaide
Philip Cohen
Philip Cohen University of Dundee
Hugh G. Nimmo
Hugh G. Nimmo University of Glasgow
Kei Sakamoto
Kei Sakamoto University of Copenhagen
Alan R. Prescott
Alan R. Prescott University of Dundee
D. Grahame Hardie
D. Grahame Hardie University of Dundee
Charles N. David
Charles N. David Ludwig-Maximilians-Universität München
Mark Stitt
Mark Stitt Max Planck Institute of Molecular Plant Physiology

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