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Biology and Biochemistry

D-Index
42
Citations
7684
World Ranking
19472
National Ranking
7942

Overview

Adam P. Geballe is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research spans several fields of study, primarily in Medicine and Biochemistry, Genetics and Molecular Biology. Within these areas, their work includes subfields such as Epidemiology, Molecular Biology, Infectious Diseases, Genetics, and Oncology.

The scientific topics Geballe focuses on cover multiple aspects of virology and molecular biology. These include:

  • Cytomegalovirus and herpesvirus research
  • Herpesvirus infections and treatments
  • Viral gastroenteritis research and epidemiology
  • SARS-CoV-2 and COVID-19 research
  • Virus-based gene therapy research
  • RNA regulation and disease
  • RNA and protein synthesis mechanisms

Geballe's recent papers demonstrate active contributions to multiple aspects of virology and molecular biology, including mechanisms of viral adaptation and virological discourse. Selected publications include:

  • Translational buffering by ribosome stalling in upstream open reading frames, 2022, PLoS Genetics
  • Virology under the Microscope-a Call for Rational Discourse, 2023, Journal of Virology
  • The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence, 2024, Journal of Virology
  • Rapid adaptation to human protein kinase R by a unique genomic rearrangement in rhesus cytomegalovirus, 2021, PLoS Pathogens
  • Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation, 2023, PLoS Pathogens

They have collaborated frequently with a group of colleagues, notably including Alexander L. Greninger, Daphne C. Avgousti, Michael Lagunoff, Stephanie J. Child, and Felicia Goodrum.

Geballe's research has been published in several scientific venues, with a notable number of works appearing in bioRxiv (Cold Spring Harbor Laboratory), Journal of Virology, PLoS Pathogens, PLoS Genetics, and Viruses.

Best Publications

  • Upstream open reading frames as regulators of mRNA translation.

    David R. Morris;Adam P. Geballe;Adam P. Geballe

  • Cytomegalovirus: pathogen, paradigm, and puzzle

    Michael Boeckh;Adam P. Geballe

  • Poxviruses deploy genomic accordions to adapt rapidly against host antiviral defenses

    Nels C. Elde;Stephanie J. Child;Michael T. Eickbush;Jacob O. Kitzman

  • Protein kinase R reveals an evolutionary model for defeating viral mimicry

    Nels C. Elde;Stephanie J. Child;Adam P. Geballe;Adam P. Geballe;Harmit S. Malik

  • CLASS I MHC-RESTRICTED CYTOTOXIC T LYMPHOCYTE RECOGNITION OF CELLS INFECTED WITH HUMAN CYTOMEGALOVIRUS DOES NOT REQUIRE ENDOGENOUS VIRAL GENE EXPRESSION^

    Stanley R. Riddell;Mike Rabin;Adam P. Geballe;William J. Britt

  • Initiation codons within 5′-leaders of mRNAs as regulators of translation

    Adam P. Geballe;David R. Morris

  • Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1.

    Stephanie J. Child;Morgan Hakki;Katherine L. De Niro;Adam P. Geballe

  • The Human Cytomegalovirus Protein TRS1 Inhibits Autophagy via Its Interaction with Beclin 1

    Magali Chaumorcel;Marion Lussignol;Lina Mouna;Yolaine Cavignac

  • The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA

    Elizabeth E. Gray;Damion Winship;Jessica M. Snyder;Stephanie J. Child

  • Functional analysis of the human cytomegalovirus US28 gene by insertion mutagenesis with the green fluorescent protein gene.

    Jeffrey Vieira;Thomas J. Schall;Lawrence Corey;Lawrence Corey;Adam P. Geballe

  • Regulation of cytomegalovirus late gene expression: gamma genes are controlled by posttranscriptional events.

    A P Geballe;F S Leach;E S Mocarski

  • Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line.

    Robert D. Harrington;Adam P. Geballe

  • A cis-acting element within the 5′ leader of a cytomegalovirus β transcript determines kinetic class

    A.P. Geballe;R.R. Spaete;E.S. Mocarski

  • Binding and Nuclear Relocalization of Protein Kinase R by Human Cytomegalovirus TRS1

    Morgan Hakki;Morgan Hakki;Emily E. Marshall;Katherine L. De Niro;Adam P. Geballe;Adam P. Geballe

  • Translational control by an upstream open reading frame in the HER-2/neu transcript.

    Stephanie J. Child;Melanie K. Miller;Adam P. Geballe

  • Translational inhibition mediated by a short upstream open reading frame in the human cytomegalovirus gpUL4 (gp48) transcript.

    Catherine R. Degnin;Mark R. Schleiss;Jianhong Cao;Adam P. Geballe

  • Translational control of cytomegalovirus gene expression is mediated by upstream AUG codons.

    A P Geballe;E S Mocarski

  • CODING SEQUENCE-DEPENDENT RIBOSOMAL ARREST AT TERMINATION OF TRANSLATION

    Jianhong Cao;Adam P. Geballe

  • Essential Role for either TRS1 or IRS1 in Human Cytomegalovirus Replication

    Emily E. Marshall;Craig J. Bierle;Craig J. Bierle;Wolfram Brune;Adam P. Geballe;Adam P. Geballe

  • Inhibition of translation termination mediated by an interaction of eukaryotic release factor 1 with a nascent peptidyl-tRNA.

    Deanna M. Janzen;Lyudmila Frolova;Lyudmila Frolova;Adam P. Geballe;Adam P. Geballe

Frequent Co-Authors

Mark R. Schleiss
Mark R. Schleiss University of Minnesota
Michael Boeckh
Michael Boeckh Fred Hutchinson Cancer Research Center
Harmit S. Malik
Harmit S. Malik Fred Hutchinson Cancer Research Center
Matthew S. Sachs
Matthew S. Sachs Texas A&M University
Jacob O. Kitzman
Jacob O. Kitzman University of Michigan–Ann Arbor
Jay Shendure
Jay Shendure University of Washington
David R. Morris
David R. Morris University of Washington
Nicholas R. Cozzarelli
Nicholas R. Cozzarelli University of California, Berkeley
Edward S. Mocarski
Edward S. Mocarski Emory University
Patrice Codogno
Patrice Codogno Université Paris Cité

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