World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
95
Citations
26851
World Ranking
641
National Ranking
350

Overview

Nicholas R. Cozzarelli was affiliated with the University of California, Berkeley in the United States. Their research spanned multiple fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Within these areas, they contributed to subfields such as Molecular Biology, Radiology, Nuclear Medicine and Imaging, and Immunology.

The scientist's work focused on topics related to cancer therapeutics and mechanisms, monoclonal and polyclonal antibodies research, and immunotherapy and immune responses. These themes were reflected in their publications and collaborations.

Nicholas R. Cozzarelli's recent recorded publication was titled "Mechanism of topology simplification by type II DNA topoisomerases," published in 2020 in UNC Libraries. This paper had garnered citations in the academic community, indicating engagement with their findings.

Frequent collaborators included Alexander V. Vologodskii, W. Zhang, V. V. Rybenkov, A. A. Podtelezhnikov, and Darshini Subramanian. These co-authorships highlighted interdisciplinary connections in their research efforts.

The main venue where they published was UNC Libraries, which hosted at least one of their noted papers.

  • Mechanism of topology simplification by type II DNA topoisomerases (2020, UNC Libraries)

  • Alexander V. Vologodskii
  • W. Zhang
  • V. V. Rybenkov
  • A. A. Podtelezhnikov
  • Darshini Subramanian

  • UNC Libraries

  • Cancer therapeutics and mechanisms
  • Monoclonal and Polyclonal Antibodies Research
  • Immunotherapy and Immune Responses

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Immunology and Microbiology

  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging
  • Immunology

Best Publications

  • Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

    Akio Sugino;Craig L. Peebles;Kenneth N. Kreuzer;Nicholas R. Cozzarelli

  • Structural transitions and elasticity from torque measurements on DNA

    Zev Bryant;Michael D. Stone;Jeff Gore;Steven B. Smith

  • Biochemical topology: applications to DNA recombination and replication.

    Steven A. Wasserman;Nicholas R. Cozzarelli

  • Topological domain structure of the Escherichia coli chromosome

    Lisa Postow;Christine D. Hardy;Javier Arsuaga;Nicholas R. Cozzarelli

  • Structure of plectonemically supercoiled DNA

    T C Boles;J H White;N R Cozzarelli

  • Energy coupling in DNA gyrase and the mechanism of action of novobiocin

    Akio Sugino;N. Patrick Higgins;Patrick O. Brown;Craig L. Peebles

  • Probability of DNA knotting and the effective diameter of the DNA double helix

    Valentin V. Rybenkov;Nicholas R. Cozzarelli;Alexander V. Vologodskii

  • Escherichia coli Mutants Thermosensitive for Deoxyribonucleic Acid Gyrase Subunit A: Effects on Deoxyribonucleic Acid Replication, Transcription, and Bacteriophage Growth

    Kenneth N. Kreuzer;Nicholas R. Cozzarelli

  • DNA overwinds when stretched

    Jeff Gore;Zev Bryant;Zev Bryant;Marcelo Nöllmann;Mai U. Le

  • Topoisomerase IV is a target of quinolones in Escherichia coli

    A B Khodursky;E L Zechiedrich;N R Cozzarelli

  • C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis

    Kirsten A. Hagstrom;Victor F. Holmes;Nicholas R. Cozzarelli;Barbara J. Meyer

  • 13S Condensin Actively Reconfigures DNA by Introducing Global Positive Writhe: Implications for Chromosome Condensation

    Keiji Kimura;Valentin V Rybenkov;Nancy J Crisona;Tatsuya Hirano

  • The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication

    David E. Adams;Eugene M. Shekhtman;E.Lynn Zechiedrich;Molly B. Schmid

  • Conformational and thermodynamic properties of supercoiled DNA.

    A V Vologodskii;N R Cozzarelli

  • A sign inversion mechanism for enzymatic supercoiling of DNA.

    Patrick O. Brown;Nicholas R. Cozzarelli

  • Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli.

    E.Lynn Zechiedrich;E.Lynn Zechiedrich;Arkady B. Khodursky;Sophie Bachellier;Robert Schneider

  • Conformational and Thermodynamic Properties of Supercoiled DNA

    Alexander V. Vologodskii;Stephen D. Levene;Konstantin V. Klenin;Maxim Frank-Kamenetskii

  • Use of site-specific recombination as a probe of DNA structure and metabolism in vivo.

    James B. Bliska;Nicholas R. Cozzarelli

  • Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli

    Brian J Peter;Brian J Peter;Javier Arsuaga;Adam M Breier;Arkady B Khodursky

  • Purification of subunits of Escherichia coli DNA gyrase and reconstitution of enzymatic activity

    N P Higgins;C L Peebles;A Sugino;N R Cozzarelli

Frequent Co-Authors

Alexander Vologodskii
Alexander Vologodskii New York University
Carlos Bustamante
Carlos Bustamante Stanford University
Patrick O. Brown
Patrick O. Brown Stanford University
Mark A. Krasnow
Mark A. Krasnow Stanford University
Akio Sugino
Akio Sugino Osaka University
Eckard Wimmer
Eckard Wimmer Stony Brook University
Alison D. O'Brien
Alison D. O'Brien Uniformed Services University of the Health Sciences
Andrew B. Onderdonk
Andrew B. Onderdonk Brigham and Women's Hospital
Lynn W. Enquist
Lynn W. Enquist Princeton University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a career in molecular biology opens the door to many related fields—particularly in health and human services. If you are seeking flexible study options, online programs can be both accessible and affordable. Some professionals build a strong foundation in scientific understanding, then branch into allied fields for more career opportunities.

Those interested in the mental health sector might consider the cheapest masters in counseling or an clinical psychology online degree to start or enhance their roles within counseling and therapy.

For a broader impact on community well-being, a human services degree online can prepare you for roles in outreach, support services, and case management. If you have a background in education, you might even wonder, can a teacher become a speech pathologist? The answer is yes—with the right coursework and credentials, career changes into specialized allied health fields are possible.

No matter your pathway, these programs offer convenient online formats to help fit education into your current lifestyle while pursuing new career directions related to science and healthcare.

Best Scientists Citing Nicholas R. Cozzarelli

Recently Published Articles