His primary areas of investigation include DNA supercoil, DNA, DNA gyrase, Molecular biology and DNA replication. The concepts of his DNA supercoil study are interwoven with issues in Chromosome and Circular bacterial chromosome. His work on Topoisomerase as part of general DNA research is frequently linked to Monte Carlo method, bridging the gap between disciplines.
His research in DNA gyrase focuses on subjects like Topoisomerase-II Inhibitor, which are connected to Transcription. His work focuses on many connections between Molecular biology and other disciplines, such as Escherichia coli, that overlap with his field of interest in Aromatic amino acids, Repressor, Gene expression and Tryptophan repressor. His work deals with themes such as Genetics and Stereochemistry, which intersect with Biophysics.
Nicholas R. Cozzarelli mainly investigates DNA, DNA supercoil, Biophysics, Molecular biology and Genetics. Nicholas R. Cozzarelli is involved in the study of DNA that focuses on Topoisomerase in particular. In Topoisomerase, Nicholas R. Cozzarelli works on issues like Catenation, which are connected to Gel electrophoresis.
Nicholas R. Cozzarelli has researched DNA supercoil in several fields, including Linking number, Circular bacterial chromosome, Site-specific recombination and DNA gyrase. In general DNA gyrase study, his work on Topoisomerase IV often relates to the realm of Novobiocin, thereby connecting several areas of interest. In his research, DNA polymerase is intimately related to Polymerase, which falls under the overarching field of Molecular biology.
Nicholas R. Cozzarelli mainly focuses on DNA, Genetics, DNA supercoil, Biophysics and DNA replication. His DNA study is concerned with the larger field of Biochemistry. His study in the field of Gene, Mutation and Chromosome segregation also crosses realms of Cockayne syndrome.
His research in DNA supercoil intersects with topics in Processivity, Topoisomerase IV, Chromosome and Circular bacterial chromosome. His Biophysics study integrates concerns from other disciplines, such as Oligonucleotide, Catenane, Helicase, Random hexamer and Prokaryotic DNA replication. Nicholas R. Cozzarelli combines subjects such as Fungal genetics and Sequence analysis with his study of DNA replication.
His scientific interests lie mostly in DNA, DNA supercoil, Genetics, DNA replication and Biophysics. In the subject of general DNA, his work in Topoisomerase is often linked to Twist, thereby combining diverse domains of study. His DNA supercoil research incorporates themes from Crystallography, Chromosome, Processivity and Stereochemistry.
His Gene, Mutation, Plasmid and Chromosome segregation study in the realm of Genetics connects with subjects such as Membrane protein. His DNA replication research integrates issues from Topoisomerase IV and Cell biology. Nicholas R. Cozzarelli regularly ties together related areas like Biochemistry in his Biophysics studies.
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Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme
Akio Sugino;Craig L. Peebles;Kenneth N. Kreuzer;Nicholas R. Cozzarelli.
Proceedings of the National Academy of Sciences of the United States of America (1977)
DNA gyrase and the supercoiling of DNA
Nicholas R. Cozzarelli.
Structural transitions and elasticity from torque measurements on DNA
Zev Bryant;Michael D. Stone;Jeff Gore;Steven B. Smith.
Biochemical topology: applications to DNA recombination and replication.
Steven A. Wasserman;Nicholas R. Cozzarelli.
Topological domain structure of the Escherichia coli chromosome
Lisa Postow;Christine D. Hardy;Javier Arsuaga;Nicholas R. Cozzarelli.
Genes & Development (2004)
Structure of plectonemically supercoiled DNA
T C Boles;J H White;N R Cozzarelli.
Journal of Molecular Biology (1990)
Energy coupling in DNA gyrase and the mechanism of action of novobiocin
Akio Sugino;N. Patrick Higgins;Patrick O. Brown;Craig L. Peebles.
Proceedings of the National Academy of Sciences of the United States of America (1978)
Probability of DNA knotting and the effective diameter of the DNA double helix
Valentin V. Rybenkov;Nicholas R. Cozzarelli;Alexander V. Vologodskii.
Proceedings of the National Academy of Sciences of the United States of America (1993)
Topoisomerase IV is a target of quinolones in Escherichia coli
A B Khodursky;E L Zechiedrich;N R Cozzarelli.
Proceedings of the National Academy of Sciences of the United States of America (1995)
C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis
Kirsten A. Hagstrom;Victor F. Holmes;Nicholas R. Cozzarelli;Barbara J. Meyer.
Genes & Development (2002)
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