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Biology and Biochemistry

D-Index
75
Citations
23441
World Ranking
5255
National Ranking
2500

Overview

Karl Drlica is affiliated with Rutgers, The State University of New Jersey in the United States. Their research focuses primarily on topics related to antibiotic resistance, bacterial genetics, and infectious diseases, with significant contributions to the understanding of bacterial death pathways and antimicrobial resistance mechanisms.

The main fields of study associated with Karl Drlica include Biochemistry, Genetics and Molecular Biology, and Medicine. Within these fields, subfields of particular interest are Molecular Biology, Infectious Diseases, Molecular Medicine, Genetics, and Materials Chemistry.

Karl Drlica's work encompasses a range of main topics, such as:

  • Antibiotic Resistance in Bacteria
  • Tuberculosis Research and Epidemiology
  • Bacterial Genetics and Biotechnology
  • Antimicrobial Resistance in Staphylococcus
  • Bacterial biofilms and quorum sensing
  • Enzyme Structure and Function
  • RNA and protein synthesis mechanisms

They have published multiple papers in various scientific venues, with frequent publications in bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, mBio, Antimicrobial Agents and Chemotherapy, and eLife.

Representative recent publications include:

  • "A broadly applicable, stress-mediated bacterial death pathway regulated by the phosphotransferase system (PTS) and the cAMP-Crp cascade," 2022, Proceedings of the National Academy of Sciences
  • "Glutamine Is Required for M1-like Polarization of Macrophages in Response to Mycobacterium tuberculosis Infection," 2022, mBio
  • "Bacterial death from treatment with fluoroquinolones and other lethal stressors," 2020, Expert Review of Anti-infective Therapy
  • "Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species," 2022, Antimicrobial Agents and Chemotherapy
  • "Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress," 2023, eLife

Karl Drlica collaborates regularly with several coauthors, including:

  • Xilin Zhao
  • Alejandro Pironti
  • Bo Shopsin
  • Gregory Putzel
  • Robert J. Ulrich

Best Publications

  • DNA gyrase, topoisomerase IV, and the 4-quinolones.

    Karl Drlica;Xilin Zhao

  • Histonelike proteins of bacteria.

    K Drlica;J Rouviere-Yaniv

  • Quinolone-mediated bacterial death.

    Karl Drlica;Muhammad Malik;Robert J. Kerns;Xilin Zhao

  • Restricting the Selection of Antibiotic-Resistant Mutants: A General Strategy Derived from Fluoroquinolone Studies

    Xilin Zhao;Karl Drlica

  • The mutant selection window and antimicrobial resistance

    Karl Drlica

  • Escherichia coli DNA topoisomerase I mutants: Increased supercoiling is corrected by mutations near gyrase genes

    Gail J. Pruss;Stephen H. Manes;Karl Drlica

  • Control of bacterial DNA supercoiling

    Karl Drlica

  • Post-stress bacterial cell death mediated by reactive oxygen species

    Yuzhi Hong;Jie Zeng;Xiuhong Wang;Xiuhong Wang;Karl Drlica

  • Inhibitors of DNA topoisomerases

    Karl Drlica;Robert J. Franco

  • Reactive oxygen species and the bacterial response to lethal stress.

    Xilin Zhao;Xilin Zhao;Karl Drlica

  • Mutant selection window hypothesis updated.

    Karl Drlica;Xilin Zhao

  • DNA supercoiling and prokaryotic transcription

    Gail J. Pruss;Karl Drlica;Karl Drlica

  • Quinolones: Action and Resistance Updated

    Karl Drlica;Hiroshi Hiasa;Robert Kerns;Muhammad Malik

  • Mechanism of fluoroquinolone action.

    Karl Drlica

  • Mutant Prevention Concentrations of Fluoroquinolones for Clinical Isolates of Streptococcus pneumoniae

    Joseph M. Blondeau;Xilin Zhao;Glen Hansen;Karl Drlica

  • Biology of bacterial deoxyribonucleic acid topoisomerases.

    K Drlica

  • FLUOROQUINOLONES: ACTION AND RESISTANCE

    Karl Drlica;Muhammad Malik

  • Effect of fluoroquinolone concentration on selection of resistant mutants of Mycobacterium bovis BCG and Staphylococcus aureus.

    Yuzhi Dong;Xilin Zhao;John Domagala;Karl Drlica

  • DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage.

    Chang-Rung Chen;Muhammad Malik;Muhammad Malik;Michael Snyder;Michael Snyder;Karl Drlica;Karl Drlica

  • Restricting the selection of antibiotic-resistant mutant bacteria: measurement and potential use of the mutant selection window.

    Xilin Zhao;Karl Drlica

Frequent Co-Authors

Xilin Zhao
Xilin Zhao Xiamen University
Abraham Pinter
Abraham Pinter Rutgers, The State University of New Jersey
Barry N. Kreiswirth
Barry N. Kreiswirth Center for Discovery and Innovation
James J. Rahal
James J. Rahal New York Hospital Queens
Michael Snyder
Michael Snyder Stanford University
James M. Musser
James M. Musser Houston Methodist
James M. Berger
James M. Berger Johns Hopkins University
Fred Russell Kramer
Fred Russell Kramer Rutgers, The State University of New Jersey
Yogendra Singh
Yogendra Singh University of Delhi
Srinand Sreevatsan
Srinand Sreevatsan Michigan State University

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