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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
11972
World Ranking
13183
National Ranking
5619

Overview

Joseph Locker is affiliated with the University of Pittsburgh in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a notable focus on Molecular Biology, Oncology, Epidemiology, Hepatology, and Genetics.

Their research addresses key topics such as Liver Disease Diagnosis and Treatment, Liver Physiology and Pathology, Ubiquitin and Proteasome Pathways, Cancer-related Molecular Pathways, Drug-Induced Hepatotoxicity and Protection, Lung Cancer Research Studies, and Renal and Related Cancers.

Joseph Locker has contributed publications to several scientific journals. Frequent publication venues include:

  • American Journal Of Pathology
  • Cellular and Molecular Gastroenterology and Hepatology
  • Cancer Research
  • American Journal of Physiology-Renal Physiology
  • Frontiers in Physiology

Their recent papers demonstrate a range of research interests and collaborations. Some of the highlighted papers include:

  • Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1 -Deficient Human and Mouse Small-Cell Lung Cancer, 2020, Cancer Research
  • Cubilin-, megalin-, and Dab2-dependent transcription revealed by CRISPR/Cas9 knockout in kidney proximal tubule cells, 2021, American Journal of Physiology-Renal Physiology
  • Transcriptional Programs Driving Shear Stress-Induced Differentiation of Kidney Proximal Tubule Cells in Culture, 2020, Frontiers in Physiology
  • Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease, 2022, Cellular and Molecular Gastroenterology and Hepatology
  • Yes-Associated Protein Is Crucial for Constitutive Androstane Receptor-Driven Hepatocyte Proliferation But Not for Induction of Drug Metabolism Genes in Mice, 2020, Hepatology

The scientist collaborates frequently with a number of co-authors, including:

  • Bharat Bhushan
  • George K. Michalopoulos
  • John Stoops
  • Anne Orr
  • Siddhi Jain

Best Publications

  • Classifying collective cancer cell invasion

    Peter Friedl;Joseph Locker;Erik Sahai;Jeffrey E. Segall

  • The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression.

    M A Nalesnik;R Jaffe;T E Starzl;A J Demetris

  • Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.

    G. D. Block;J. Locker;W. C. Bowen;B. E. Petersen

  • The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation.

    Elsie S. Lee;Joseph Locker;Michael Nalesnik;Jorge Reyes

  • Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: A distinct entity?

    Beverly P. Nelson;Michael A. Nalesnik;David W. Bahler;Joseph Locker

  • Molecular genetic analysis of lymphoid tumors arising after organ transplantation.

    J. Locker;M. Nalesnik

  • Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.

    H. Huang;H. Wang;M. Sinz;M. Zoeckler

  • The Clinical Spectrum, Pathology, and Clonal Analysis of Epstein-Barr Virus–Associated Lymphoproliferative Disorders in Heart–Lung Transplant Recipients

    Parmjeet S. Randhawa;Samuel A. Yousem;Irwin L. Paradis;James A. Dauber

  • Characterization of a second human pulmonary surfactant-associated protein SP-A gene.

    Sikandar L. Katyal;Gurmukh Singh;Joseph Locker

  • Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice

    Hongbo Wang;Hongbo Wang;Hongbo Wang;Frederick Bauzon;Peng Ji;Peng Ji;Xiaoliang Xu;Xiaoliang Xu;Xiaoliang Xu

  • DNA methylation and hepatocarcinogenesis in rats fed a choline-devoid diet

    Joseph Locker;Tirumuru V. Reddy;Benito Lombardi

  • A dictionary of transcription control sequences.

    Joseph Locker;Gregory Buzard

  • ErbB3-dependent motility and intravasation in breast cancer metastasis.

    Chengsen Xue;Fubo Liang;Radma Mahmood;Magalis Vuolo

  • Indolent mantle cell lymphoma with nodal involvement and mutated immunoglobulin heavy chain genes.

    Laurentia Nodit;David W Bahler;Samuel A Jacobs;Joseph Locker

  • Resetting the transcription factor network reverses terminal chronic hepatic failure

    Taichiro Nishikawa;Aaron Bell;Jenna M. Brooks;Kentaro Setoyama

  • Posttransplant lymphoproliferative disorders in heart-lung transplant recipients: Primary presentation in the allograft

    Samuel A. Yousem;Parmjeet Randhawa;Joseph Locker;Irwin L. Paradis

  • c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet

    Nalini Chandar;Benito Lombardi;Joseph Locker

  • Recurrent Epstein-Barr virus-associated lesions in organ transplant recipients

    Tsung Teh Wu;Steven H. Swerdlow;Joseph Locker;David Bahler

  • A common set of immediate-early response genes in liver regeneration and hyperplasia.

    Joseph Locker;Jianmin Tian;Robert Carver;Danilo Concas;Danilo Concas

  • Rybp/DEDAF is required for early postimplantation and for central nervous system development.

    Melinda K. Pirity;Joseph Locker;Nicole Schreiber-Agus

Frequent Co-Authors

Amedeo Columbano
Amedeo Columbano University of Cagliari
Michael A. Nalesnik
Michael A. Nalesnik University of Pittsburgh
Thomas J. Gill
Thomas J. Gill New England Baptist Hospital
Parmjeet Randhawa
Parmjeet Randhawa University of Pittsburgh
Jeffrey E. Segall
Jeffrey E. Segall Albert Einstein College of Medicine
John J. Fung
John J. Fung University of Chicago
George K. Michalopoulos
George K. Michalopoulos University of Pittsburgh
Satdarshan P. Monga
Satdarshan P. Monga University of Pittsburgh
Theresa L. Whiteside
Theresa L. Whiteside University of Pittsburgh
Jorge Reyes
Jorge Reyes University of Washington

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