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Biology and Biochemistry

D-Index
72
Citations
23793
World Ranking
6178
National Ranking
2906

Overview

Donald P. Bottaro is a researcher affiliated with the National Institutes of Health in the United States. Their work spans several areas within medicine and biochemistry, genetics, and molecular biology, and they have contributed to research in fields such as pulmonary and respiratory medicine, surgery, molecular biology, oncology, and cancer research.

Their research focuses on several main topics, including:

  • Bladder and urothelial cancer treatments
  • Renal cell carcinoma treatment
  • Cancer immunotherapy and biomarkers
  • Urinary and genital oncology studies
  • Angiogenesis and VEGF in cancer
  • Cancer genomics and diagnostics
  • Ferroptosis and cancer prognosis

Donald P. Bottaro's recent publications cover clinical oncology and cancer therapeutics, including multiple studies on combination therapies and biomarkers in genitourinary cancers. Some of the notable recent papers are:

  • Phase I Study of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced or Metastatic Urothelial Carcinoma and Other Genitourinary Tumors, 2020, Journal of Clinical Oncology
  • Cabozantinib in patients with platinum-refractory metastatic urothelial carcinoma: an open-label, single-centre, phase 2 trial, 2020, The Lancet Oncology
  • Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer, 2020, Clinical Cancer Research
  • Final Results From a Phase I Trial and Expansion Cohorts of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced/Metastatic Genitourinary Tumors, 2024, Journal of Clinical Oncology
  • The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma, 2024, Cell Reports

Their frequent co-authors include:

  • Andrea B. Apolo
  • Rene Costello
  • Lisa M. Cordes
  • Seth M. Steinberg
  • Scot A. Niglio

Donald P. Bottaro has published extensively in various scientific venues. The most frequent publication journals and platforms are:

  • Journal of Clinical Oncology
  • PLoS ONE
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Cancers
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product

    D. P. Bottaro;J. S. Rubin;D. L. Faletto;A. M.-L. Chan

  • Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

    W. Marston Linehan;Paul T. Spellman;Christopher J. Ricketts;Chad J. Creighton

  • Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

    M Santoro;F Carlomagno;A Romano;D P Bottaro

  • Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

    Toru Miki;Donald P. Bottaro;Timothy P. Fleming;Cheryl L. Smith

  • The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

    Christopher J Ricketts;Aguirre A De Cubas;Huihui Fan;Christof C Smith

  • A BROAD-SPECTRUM HUMAN LUNG FIBROBLAST-DERIVED MITOGEN IS A VARIANT OF HEPATOCYTE GROWTH FACTOR

    J S Rubin;A M Chan;D P Bottaro;W H Burgess

  • Targeting the c-Met Signaling Pathway in Cancer

    B. Peruzzi;D. P Bottaro

  • Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop.

    Toru Miki;Timothy P. Fleming;Donald P. Bottaro;Jeffrey S. Rubin

  • PDGF induction of tyrosine phosphorylation of GTPase activating protein.

    Christopher J. Molloy;Donald P. Bottaro;Timothy P. Fleming;Mark S. Marshall

  • Phase II and Biomarker Study of the Dual MET/VEGFR2 Inhibitor Foretinib in Patients With Papillary Renal Cell Carcinoma

    Toni K. Choueiri;Ulka Vaishampayan;Jonathan E. Rosenberg;Theodore F. Logan

  • Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling *

    Aykut Üren;Frieda Reichsman;Vasiliki Anest;William G. Taylor

  • Keratinocyte growth factor.

    J S Rubin;D P Bottaro;M Chedid;T Miki

  • Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.

    Paolo Fedi;Anna Bafico;Almudena Nieto Soria;Wilson H. Burgess

  • Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product

    Jeffrey S. Rubin;Donald P. Bottaro;Stuart A. Aaronson

  • Smad2 transduces common signals from receptor serine–threonine and tyrosine kinases

    Mark P. de Caestecker;W. Tony Parks;Chistopher J. Frank;Paola Castagnino

  • Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

    Fengju Chen;Yiqun Zhang;Yasin Şenbabaoğlu;Giovanni Ciriello

  • c-Met Autocrine Activation Induces Development of Malignant Melanoma and Acquisition of the Metastatic Phenotype

    Toshiyuki Otsuka;Hisashi Takayama;Hisashi Takayama;Richard Sharp;Giulia Celli

  • Genetic Basis of Cancer of the Kidney: Disease-Specific Approaches to Therapy

    W. Marston Linehan;James Vasselli;Ramaprasad Srinivasan;McClellan M. Walther

  • Targeting the HGF/Met signalling pathway in cancer.

    Fabiola Cecchi;Daniel C. Rabe;Donald P. Bottaro

  • The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (vol 23, pg 313, 2018)

    Christopher J Ricketts;Aguirre A De Cubas;Huihui Fan;Christof C Smith

Frequent Co-Authors

W. Marston Linehan
W. Marston Linehan National Institutes of Health
Stuart A. Aaronson
Stuart A. Aaronson Icahn School of Medicine at Mount Sinai
Jeffrey S. Rubin
Jeffrey S. Rubin National Institutes of Health
Terrence R. Burke
Terrence R. Burke National Institutes of Health
James H. Doroshow
James H. Doroshow National Institutes of Health
Seth M. Steinberg
Seth M. Steinberg National Institutes of Health
Maria J. Merino
Maria J. Merino National Institutes of Health
Jane B. Trepel
Jane B. Trepel National Institutes of Health
Toru Miki
Toru Miki National Institutes of Health
Laura S. Schmidt
Laura S. Schmidt National Institutes of Health

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