World's Best Scientists 2026 revealed!
M. Luisa Iruela-Arispe

M. Luisa Iruela-Arispe

D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
29952
World Ranking
2434
National Ranking
1292

Medicine

D-Index
90
Citations
30010
World Ranking
12200
National Ranking
6255

Overview

M. Luisa Iruela-Arispe is affiliated with Northwestern University in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a strong interdisciplinary focus. The primary fields of study include biochemistry, genetics and molecular biology with 56 publications, and medicine with 50 publications. Their work further delves into specialized subfields such as molecular biology, immunology, neurology, cell biology, and pulmonary and respiratory medicine.

The scientist's research topics feature a range of significant biomedical subjects, including single-cell and spatial transcriptomics, angiogenesis and VEGF in cancer, renal and related cancers, congenital heart defects research, cell adhesion molecules research, RNA modifications in cancer, and erythrocyte function and pathophysiology.

Selected recent publications demonstrate a continuous contribution to contemporary biomedical research. Some notable papers include:

  • Mapping human haematopoietic stem cells from haemogenic endothelium to birth, 2022, Nature
  • Mechanisms of Endothelial Regeneration and Vascular Repair and Their Application to Regenerative Medicine, 2020, American Journal Of Pathology
  • The cellular architecture of the antimicrobial response network in human leprosy granulomas, 2021, Nature Immunology
  • Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state, 2022, Nature Cardiovascular Research
  • Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice, 2023, Journal of Clinical Investigation

The scientist frequently collaborates with a network of co-authors, including Feiyang Ma, Matteo Pellegrini, Jocelynda Salvador, Gloria E. Hernandez, and Ana Mompeón. These partnerships reflect ongoing multidisciplinary work across immunology, vascular biology, and related biomedical fields.

Publication venues for their work often include leading scientific journals and repositories such as bioRxiv (Cold Spring Harbor Laboratory), Current Opinion in Hematology, Nature Cardiovascular Research, Journal of Clinical Investigation, and Cell Reports. This range indicates engagement with cutting-edge research communities and dissemination channels relevant to their expertise.

Best Publications

  • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

    Mats Hellström;Li Kun Phng;Jennifer J. Hofmann;Elisabet Wallgard

  • Autocrine VEGF Signaling Is Required for Vascular Homeostasis

    Sunyoung Lee;Tom T. Chen;Chad L. Barber;Maria C. Jordan

  • Myc-driven murine prostate cancer shares molecular features with human prostate tumors.

    Katharine Ellwood-Yen;Thomas G. Graeber;John Wongvipat;M. Luisa Iruela-Arispe

  • Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

    Sunyoung Lee;Shahla M. Jilani;Ganka V. Nikolova;Darren R. Carpizo

  • Fate tracing reveals the endothelial origin of hematopoietic stem cells.

    Ann C. Zovein;Jennifer J. Hofmann;Maureen Lynch;Wendy J. French

  • Consensus guidelines for the use and interpretation of angiogenesis assays

    Patrycja Nowak-Sliwinska;Kari Alitalo;Elizabeth Allen;Andrey Anisimov

  • Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis.

    Yajaira Suárez;Carlos Fernández-Hernando;Jun Yu;Scott A. Gerber

  • Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

    Juan Carlos Rodríguez-Manzaneque;Timothy F. Lane;María Asunción Ortega;Richard O. Hynes

  • METH-1, a Human Ortholog of ADAMTS-1, and METH-2 Are Members of a New Family of Proteins with Angio-inhibitory Activity

    Francisca Vázquez;Gregg Hastings;Maria Asunción Ortega;Timothy F Lane

  • Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.

    John D. Sandy;Jennifer Westling;Richard D. Kenagy;M. Luisa Iruela-Arispe

  • Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

    Natividad Villa;Liberty Walker;Claire E. Lindsell;Judith Gasson

  • VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells.

    Jackelyn A. Alva;Ann C. Zovein;Arnaud Monvoisin;Thomas Murphy

  • Inactivation of erythropoietin leads to defects in cardiac morphogenesis

    Hong Wu;Sang Hoon Lee;Jing Gao;Xin Liu

  • Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

    Ioanna Keklikoglou;Chiara Cianciaruso;Esra Güç;Mario Leonardo Squadrito

  • The chicken chorioallantoic membrane model in biology, medicine and bioengineering.

    Patrycja Nowak-Sliwinska;Tatiana Segura;M. Luisa Iruela-Arispe

  • The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors

    E W Raines;T F Lane;M L Iruela-Arispe;R Ross

  • Cellular and molecular mechanisms of vascular lumen formation.

    M. Luisa Iruela-Arispe;George E. Davis

  • Inhibition of Angiogenesis by Thrombospondin-1 Is Mediated by 2 Independent Regions Within the Type 1 Repeats

    M. Luisa Iruela-Arispe;Michele Lombardo;Henry C. Krutzsch;Jack Lawler

  • Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy

    Saul J. Priceman;James L. Sung;Zory Shaposhnik;Jeremy B. Burton;Jeremy B. Burton

  • Extracellular Matrix, Inflammation, and the Angiogenic Response

    Alicia G. Arroyo;M. Luisa Iruela-Arispe

Frequent Co-Authors

E. Helene Sage
E. Helene Sage Benaroya Research Institute
Matteo Pellegrini
Matteo Pellegrini University of California, Los Angeles
Hanna K.A. Mikkola
Hanna K.A. Mikkola University of California, Los Angeles
Hellmut G. Augustin
Hellmut G. Augustin Heidelberg University
Peter Tontonoz
Peter Tontonoz University of California, Los Angeles
Lily Wu
Lily Wu University of California, Los Angeles
Michele De Palma
Michele De Palma École Polytechnique Fédérale de Lausanne
Freddy Radtke
Freddy Radtke École Polytechnique Fédérale de Lausanne
Anne Eichmann
Anne Eichmann Yale University
Elisabetta Dejana
Elisabetta Dejana Uppsala University

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