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Biology and Biochemistry

D-Index
63
Citations
22178
World Ranking
10000
National Ranking
173

Overview

Michele De Palma is affiliated with the École Polytechnique Fédérale de Lausanne in Switzerland. Their research primarily focuses on the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. The subfields of study include Immunology, Molecular Biology, Oncology, Cancer Research, and Pulmonary and Respiratory Medicine.

Their published work spans several main research topics, including:

  • Immune cells in cancer
  • Immunotherapy and Immune Responses
  • Phagocytosis and Immune Regulation
  • Angiogenesis and VEGF in Cancer
  • Extracellular vesicles in disease
  • CAR-T cell therapy research
  • Epigenetics and DNA Methylation

Some recent notable papers authored by Michele De Palma include:

  • "Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles" (2021) published in Nature Communications
  • "Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models" (2021) published in Science Translational Medicine
  • "Biology and therapeutic targeting of tumour-associated macrophages" (2020) published in The Journal of Pathology
  • "Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice" (2020) published in Journal of Clinical Investigation
  • "Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy" (2023) published in Nature Cancer

Frequent publication venues for Michele De Palma include:

  • Science Translational Medicine
  • Nature Cancer
  • Cell Reports
  • Nature Communications
  • iScience

The scientist has collaborated multiple times with several co-authors, including:

  • Alan Guichard
  • Nahal Mansouri
  • Amaia Martínez-Usatorre
  • Nadine Fournier
  • Bruno Torchia

Michele De Palma's book contributions include a publication with Frontiers Media titled "Immunity, Cancer and the Microenvironment: Resolving a 3-Way Standoff" published in 2023.

Best Publications

  • Microenvironmental regulation of tumour angiogenesis

    Michele De Palma;Daniela Biziato;Tatiana V. Petrova

  • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

    Michele De Palma;Mary Anna Venneri;Rossella Galli;Lucia Sergi Sergi

  • Macrophage Regulation of Tumor Responses to Anticancer Therapies

    Michele De Palma;Claire E. Lewis

  • HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.

    Charlotte Rolny;Massimiliano Mazzone;Sònia Tugues;Damya Laoui

  • Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

    Roberta Mazzieri;Ferdinando Pucci;Davide Moi;Erika Zonari

  • Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells.

    Michele De Palma;Mary Anna Venneri;Cristina Roca;Luigi Naldini

  • FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

    Pauline Andreu;Magnus Johansson;Nesrine I. Affara;Ferdinando Pucci

  • Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells

    Mario Leonardo Squadrito;Caroline Baer;Frédéric Burdet;Claudio Maderna

  • Consensus guidelines for the use and interpretation of angiogenesis assays

    Patrycja Nowak-Sliwinska;Kari Alitalo;Elizabeth Allen;Andrey Anisimov

  • Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.

    Mary Anna Venneri;Michele De Palma;Maurilio Ponzoni;Ferdinando Pucci

  • Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

    Martina Schmittnaegel;Nicolò Rigamonti;Ece Kadioglu;Antonino Cassará

  • Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

    Russell Hughes;Bin-Zhi Qian;Charlotte Rowan;Munitta Muthana

  • Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

    Ioanna Keklikoglou;Chiara Cianciaruso;Esra Güç;Mario Leonardo Squadrito

  • Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions

    Seth B. Coffelt;Andrea O. Tal;Alexander Scholz;Michele De Palma

  • Engineering dendritic cell vaccines to improve cancer immunotherapy

    Caleb R Perez;Michele De Palma

  • Tumor-Targeted Interferon-α Delivery by Tie2-Expressing Monocytes Inhibits Tumor Growth and Metastasis

    Michele De Palma;Roberta Mazzieri;Letterio S. Politi;Ferdinando Pucci

  • Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications

    Michele De Palma;Craig Murdoch;Mary Anna Venneri;Luigi Naldini

  • Correction of metachromatic leukodystrophy in the mouse model by transplantation of genetically modified hematopoietic stem cells

    Alessandra Biffi;Michele De Palma;Angelo Quattrini;Ubaldo Del Carro

  • Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

    Yukiji Takeda;Sandra Maria Araújo da Costa;Estelle Delamarre;Carmen Roncal

  • A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships

    Ferdinando Pucci;Mary Anna Venneri;Daniela Biziato;Alessandro Nonis

Frequent Co-Authors

Luigi Naldini
Luigi Naldini Vita-Salute San Raffaele University
Claire E. Lewis
Claire E. Lewis University of Sheffield
M. Luisa Iruela-Arispe
M. Luisa Iruela-Arispe Northwestern University
Jeffrey W. Pollard
Jeffrey W. Pollard University of Edinburgh
George Coukos
George Coukos Cornell University
Tatiana V. Petrova
Tatiana V. Petrova University of Lausanne
Tambet Teesalu
Tambet Teesalu University of Tartu
Rakesh K. Jain
Rakesh K. Jain Harvard University
Lisa M. Coussens
Lisa M. Coussens Oregon Health & Science University

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