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Immunology

D-Index
70
Citations
17710
World Ranking
2417
National Ranking
63

Overview

Doron Merkler is affiliated with the University of Geneva in Switzerland. Their research spans multiple areas within immunology and medicine, focusing on the intersection of immune cell function, neuroinflammation, and molecular biology.

The scientist's main fields of study include:

  • Immunology and Microbiology
  • Medicine

Within these fields, they have a strong emphasis on these subfields:

  • Immunology
  • Neurology
  • Molecular Biology
  • Epidemiology
  • Genetics

The core topics of Doron Merkler's work are centered around:

  • T-cell and B-cell Immunology
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Interferon and immune responses
  • Immune Response and Inflammation
  • Virus-based gene therapy research

Merkler has contributed to a variety of scientific journals and publication venues, with frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • Cell
  • Cell Reports

Recent papers authored or co-authored by Doron Merkler include:

  • Magnesium sensing via LFA-1 regulates CD8+ T cell effector function, 2022, Cell
  • STING orchestrates the neuronal inflammatory stress response in multiple sclerosis, 2024, Cell
  • Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation, 2021, Nature Neuroscience
  • Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology, 2020, Cell Reports
  • Tissue-resident CD8 + T cells drive compartmentalized and chronic autoimmune damage against CNS neurons, 2022, Science Translational Medicine

The scientist has collaborated extensively with several researchers, among the most frequent co-authors are:

  • Ingrid Wagner
  • Mario Kreutzfeldt
  • Daniel D. Pinschewer
  • Giovanni Di Liberto
  • Ilena Vincenti

Best Publications

  • Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

    Alexander Mildner;Hauke Schmidt;Mirko Nitsche;Doron Merkler

  • High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

    Dunja Mrdjen;Anto Pavlovic;Felix J. Hartmann;Bettina Schreiner

  • TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

    Francesca Alfei;Kristiyan Kanev;Maike Hofmann;Ming Wu

  • A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

    Ivana Nikić;Doron Merkler;Doron Merkler;Catherine Sorbara;Mary Brinkoetter

  • The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

    Weldy V. Bonilla;Anja Fröhlich;Anja Fröhlich;Karin Senn;Sandra Kallert

  • Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue

    Nicolas Snaidero;Wiebke Möbius;Tim Czopka;Liesbeth H.P. Hekking

  • Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

    Marco Prinz;Marco Prinz;Hauke Schmidt;Alexander Mildner;Alexander Mildner;Klaus-Peter Knobeloch

  • Locomotor Recovery in Spinal Cord-Injured Rats Treated with an Antibody Neutralizing the Myelin-Associated Neurite Growth Inhibitor Nogo-A

    Doron Merkler;Gerlinde A. S. Metz;Olivier Raineteau;Volker Dietz

  • Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

    Caroline Fecher;Caroline Fecher;Caroline Fecher;Laura Trovò;Laura Trovò;Stephan A. Müller;Stephan A. Müller;Nicolas Snaidero;Nicolas Snaidero

  • Aggravation of viral hepatitis by platelet-derived serotonin

    Philipp A. Lang;Claudio Contaldo;Panco Georgiev;Ashraf Mohammad El-Badry

  • A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination.

    Doron Merkler;Tristan Ernsting;Martin Kerschensteiner;Wolfgang Brück

  • Erratum: High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease (Immunity (2018) 48(2) (380–395.e6) (S1074761318300323) (10.1016/j.immuni.2018.01.011))

    Dunja Mrdjen;Anto Pavlovic;Felix J. Hartmann;Bettina Schreiner

  • Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

    Karin Steinbach;Ilena Vincenti;Mario Kreutzfeldt;Nicolas Page

  • The Immune System Bridges the Gut Microbiota with Systemic Energy Homeostasis: Focus on TLRs, Mucosal Barrier, and SCFAs

    Martina Spiljar;Doron Merkler;Mirko Trajkovski

  • USP18 lack in microglia causes destructive interferonopathy of the mouse brain

    Tobias Goldmann;Nicolas Zeller;Jenni Raasch;Katrin Kierdorf

  • TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.

    Benjamin Schattling;Karin Steinbach;Karin Steinbach;Edda Thies;Martin Kruse

  • Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis

    Muriel B. Sättler;Doron Merkler;Katharina Maier;Christine Stadelmann

  • Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

    Moumita Datta;Ori Staszewski;Elena Raschi;Maximilian Frosch

  • Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

    Salvatore Fabbiano;Nicolas Suárez-Zamorano;Claire Chevalier;Vladimir Lazarević

  • Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping.

    Giovanni Di Liberto;Stanislav Pantelyushin;Mario Kreutzfeldt;Nicolas Page

  • Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection

    Sarah Enouz;Lucie Carrié;Doron Merkler;Doron Merkler;Michael J. Bevan

  • Pervasive Axonal Transport Deficits in Multiple Sclerosis Models

    Catherine Diamante Sorbara;Catherine Diamante Sorbara;Naomi Elizabeth Wagner;Anne Ladwig;Ivana Nikić

  • Treadmill training in incomplete spinal cord injured rats

    Karim Fouad;Gerlinde A.S Metz;Doron Merkler;Volker Dietz

Frequent Co-Authors

Wolfgang Brück
Wolfgang Brück University of Göttingen
Daniel D. Pinschewer
Daniel D. Pinschewer University of Basel
Christine Stadelmann
Christine Stadelmann University of Göttingen
Thomas Misgeld
Thomas Misgeld Technical University of Munich
Martin Kerschensteiner
Martin Kerschensteiner Ludwig-Maximilians-Universität München
Mikael Simons
Mikael Simons German Center for Neurodegenerative Diseases
Max Löhning
Max Löhning Charité - University Medicine Berlin
James Sharpe
James Sharpe European Bioinformatics Institute
Martin E. Schwab
Martin E. Schwab University of Zurich
Marco Prinz
Marco Prinz University of Freiburg

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