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Biology and Biochemistry

D-Index
56
Citations
11795
World Ranking
14388
National Ranking
1129

Overview

James Sharpe is affiliated with the European Bioinformatics Institute in the United Kingdom. Their research mainly spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus also on Medicine.

Their work covers various subfields including Molecular Biology, Public Health, Environmental and Occupational Health, Genetics, Immunology, and Biophysics. This interdisciplinary approach supports their research into key scientific topics.

The main research topics James Sharpe addresses include:

  • Developmental Biology and Gene Regulation
  • Single-cell and spatial transcriptomics
  • Pluripotent Stem Cells Research
  • Cellular Mechanics and Interactions
  • Cell Image Analysis Techniques
  • Down syndrome and intellectual disability research
  • Congenital heart defects research

They have authored numerous papers across influential publication venues. Frequent venues for their publications include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Development
  • arXiv (Cornell University)
  • The FASEB Journal

Some recent papers authored by James Sharpe are:

  • "Periodic formation of epithelial somites from human pluripotent stem cells", 2022, Nature Communications
  • "Salivary gland macrophages and tissue-resident CD8 + T cells cooperate for homeostatic organ surveillance", 2020, Science Immunology
  • "Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes", 2020, Communications Biology
  • "Arrested coalescence of multicellular aggregates", 2022, Soft Matter
  • "Green tea extracts containing epigallocatechin-3-gallate modulate facial development in Down syndrome", 2021, Scientific Reports

Frequent collaborators in James Sharpe's research include:

  • Fumio Nakaki
  • Neus Martínez-Abadías
  • Nicola Gritti
  • Vikas Trivedi
  • Marco Musy

Best Publications

  • Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies

    James Sharpe;Ulf Ahlgren;Paul Perry;Bill Hill

  • Senescence is a developmental mechanism that contributes to embryonic growth and patterning.

    Mekayla Storer;Alba Mas;Alexandre Robert-Moreno;Matteo Pecoraro

  • Positional information and reaction-diffusion: two big ideas in developmental biology combine.

    Jeremy B. A. Green;James Sharpe

  • Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism

    Rushikesh Sheth;Luciano Marcon;Luciano Marcon;M. Félix Bastida;M. Félix Bastida;Marisa Junco

  • Optical projection tomography

    James Alexander Sharpe

  • Tomographic molecular imaging and 3D quantification within adult mouse organs.

    Tomas Alanentalo;Amir Asayesh;Harris Morrison;Christina E Lorén

  • Reprogramming Hox Expression in the Vertebrate Hindbrain: Influence of Paraxial Mesoderm and Rhombomere Transposition

    Nobue Itasaki;James Sharpe;Alastair Morrison;Robb Krumlauf

  • Optical projection tomography as a new tool for studying embryo anatomy

    James Sharpe

  • The role of spatially controlled cell proliferation in limb bud morphogenesis.

    Bernd Boehm;Henrik Westerberg;Gaja Lesnicar-Pucko;Sahdia Raja

  • An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients

    James Cotterell;James Sharpe

  • EMAP and EMAGE: a framework for understanding spatially organized data.

    Richard A. Baldock;Jonathan Bard;Jonathan Bard;Albert Burger;Nicholas Burton

  • Mechanobiology of embryonic skeletal development: Insights from animal models.

    Niamh C. Nowlan;James Sharpe;Karen A. Roddy;Patrick J. Prendergast

  • Selectivity, sharing and competitive interactions in the regulation of Hoxb genes

    James Sharpe;Stefan Nonchev;Alex Gould;Jenny Whiting

  • Visualizing plant development and gene expression in three dimensions using optical projection tomography.

    Karen Lee;Jerome Avondo;Harris Morrison;Lilian Blot

  • Morphogenesis in robot swarms

    Ivica Slavkov;Daniel Carrillo-Zapata;Daniel Carrillo-Zapata;Noemi Carranza;Xavier Diego;Xavier Diego

  • A unified design space of synthetic stripe-forming networks.

    Yolanda Schaerli;Andreea Munteanu;Andreea Munteanu;Magüi Gili;Magüi Gili;James Cotterell;James Cotterell

  • Identification of Sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch

    James Sharpe;Laura Lettice;Jacob Hecksher-Sørensen;Margaret Fox

  • Perspective: The promise of multi-cellular engineered living systems.

    Roger D. Kamm;Rashid Bashir;Natasha Arora;Roy D. Dar

  • Turing patterns in development: what about the horse part?

    Luciano Marcon;James Sharpe;James Sharpe

  • 3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19)

    Kristen Summerhurst;Margaret Stark;James Sharpe;Duncan Davidson

Frequent Co-Authors

Duncan Davidson
Duncan Davidson University of Edinburgh
Andreas Wagner
Andreas Wagner University of Zurich
Shigehiro Kuraku
Shigehiro Kuraku National Institute of Genetics
Jorge Ripoll
Jorge Ripoll Carlos III University of Madrid
Doron Merkler
Doron Merkler University of Geneva
Miguel Torres
Miguel Torres Spanish National Centre for Cardiovascular Research
Robb Krumlauf
Robb Krumlauf Stowers Institute for Medical Research
Saverio Bellusci
Saverio Bellusci University of Giessen
Joan T. Richtsmeier
Joan T. Richtsmeier Pennsylvania State University
Dan Holmberg
Dan Holmberg Lund University

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