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Lawrence I. Rothblum

Lawrence I. Rothblum

D-Index & Metrics

Molecular Biology

D-Index
56
Citations
9594
World Ranking
2218
National Ranking
1099

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Lawrence I. Rothblum is affiliated with the University of Oklahoma in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a specific focus on Molecular Biology. The scientist's work spans key topics including RNA Research and Splicing, Genomics and Chromatin Dynamics, RNA modifications and cancer, CRISPR and Genetic Engineering, Plant Virus Research Studies, and mechanisms of RNA and protein synthesis.

Their publication record includes studies published in venues such as Genes, Journal of Biological Chemistry, Biochemical Society Transactions, bioRxiv (Cold Spring Harbor Laboratory), and The FASEB Journal. Below are some of the recent papers authored or coauthored by Rothblum:

  • Dynamics of the RNA polymerase I TFIIF/TFIIE-like subcomplex: a mini-review, 2020, Biochemical Society Transactions
  • PAF49: An RNA Polymerase I subunit essential for rDNA transcription and stabilization of PAF53, 2023, Journal of Biological Chemistry
  • The Mammalian and Yeast A49 and A34 Heterodimers: Homologous but Not the Same, 2021, Genes
  • Targeted knockdown of the PAF49 component of the PAF53/PAF49 heterodimer causes the degradation of PAF53, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • The Codependent Expression of Yeast RNA Polymerase I Rpa34/Rpa49 Heterodimer Subcomplex, 2022, The FASEB Journal

Frequent co-authors in their research activities include Rachel McNamar, Bruce A. Knutson, Kairo N. Baylor, Aula M. Fakhouri, and Katrina Rothblum. These collaborations have contributed to multiple publications and studies exploring various aspects of RNA polymerase complexes and related molecular biology topics.

Lawrence I. Rothblum's body of work addresses several aspects of RNA biology and transcription regulation, particularly focusing on RNA polymerase I and its subunits, as well as the interplay of protein complexes involved in gene expression. Their involvement in research related to both mammalian and yeast systems reflects a comparative approach to understanding conserved molecular mechanisms.

Among professional recognitions, Rothblum was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2018.

Best Publications

  • mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

    Katherine M. Hannan;Yves Brandenburger;Anna Jenkins;Kerith Sharkey

  • SnRNAs, SnRNPs, and RNA processing.

    H Busch;R Reddy;L Rothblum;Y C Choi

  • A Kinetic Framework for a Mammalian RNA Polymerase in Vivo

    Miroslav Dundr;Urs Hoffmann-Rohrer;Qiyue Hu;Ingrid Grummt

  • Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product

    Alice H. Cavanaugh;William M. Hempel;Laura J. Taylor;Vitaly Rogalsky

  • An Immediate Response of Ribosomal Transcription to Growth Factor Stimulation in Mammals Is Mediated by ERK Phosphorylation of UBF

    Victor Y Stefanovsky;Guillaume Pelletier;Ross Hannan;Thérèse Gagnon-Kugler

  • Rapid, small-scale RNA isolation from tissue culture cells.

    Wenqin Xie;L. I. Rothblum

  • Growth Factor Signaling Regulates Elongation of RNA Polymerase I Transcription in Mammals via UBF Phosphorylation and r-Chromatin Remodeling

    Victor Stefanovsky;Frédéric Langlois;Thérèse Gagnon-Kugler;Larry I. Rothblum

  • UBF levels determine the number of active ribosomal RNA genes in mammals.

    Elaine Sanij;Gretchen Poortinga;Kerith Sharkey;Sandy Hung

  • Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury.

    P L Zhang;L I Rothblum;W K Han;T M Blasick

  • Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta.

    Charles M. Schworer;Lawrence I. Rothblum;Thomas J. Thekkumkara;Harold A. Singer

  • Nucleologenesis: U3 snRNA-containing prenucleolar bodies move to sites of active pre-rRNA transcription after mitosis.

    Luis F. Jiménez-García;M. D L Segura-Valdez;Robert L. Ochs;Lawrence I. Rothblum

  • Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1.

    K. M. Hannan;R. D. Hannan;S. D. Smith;L. S. Jefferson

  • Identification of two forms of the RNA polymerase I transcription factor UBF.

    Daniel J. O'Mahony;Lawrence I. Rothblum

  • Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription.

    Guillaume Pelletier;Victor Y. Stefanovsky;Marlène Faubladier;Iwona Hirschler-Laszkiewicz

  • Transcription by RNA polymerase I.

    Hannan Km;Hannan Rd;Rothblum Li

  • Dysregulation of RNA polymerase I transcription during disease

    Katherine M Hannan;Elaine Sanij;Lawrence I Rothblum;Ross D Hannan

  • Phosphorylation of Eukaryotic Translation Initiation Factor 2α Coordinates rRNA Transcription and Translation Inhibition during Endoplasmic Reticulum Stress

    Jenny B. DuRose;Donalyn Scheuner;Randal J. Kaufman;Lawrence I. Rothblum

  • Identification of a silver binding protein associated with the cytological silver staining of actively transcribing nucleolar regions

    Howard R. Hubbell;Lawrence I. Rothblum;T.C. Hsu

  • Characterization of factors that direct transcription of rat ribosomal DNA.

    S D Smith;E Oriahi;D Lowe;H F Yang-Yen

  • Rrn3 Phosphorylation Is a Regulatory Checkpoint for Ribosome Biogenesis

    Alice H. Cavanaugh;Iwona Hirschler-Laszkiewicz;Qiyue Hu;Miroslav Dundr

Frequent Co-Authors

Ross D. Hannan
Ross D. Hannan Australian National University
Joseph Y. Cheung
Joseph Y. Cheung Temple University
Harris Busch
Harris Busch Baylor College of Medicine
Richard B. Pearson
Richard B. Pearson Peter MacCallum Cancer Centre
David J. Carey
David J. Carey Geisinger Health System
Leonard S. Jefferson
Leonard S. Jefferson Pennsylvania State University
Jonathan Lytton
Jonathan Lytton University of Calgary
George Harauz
George Harauz University of Guelph
Gregory J. Goodall
Gregory J. Goodall University of Adelaide
Craig S. Pikaard
Craig S. Pikaard Indiana University

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