Gabriele Saretzki

Overview

Best Publications

• A DNA damage checkpoint response in telomere-initiated senescence

  Fabrizio d'Adda di Fagagna;Philip M. Reaper;Lorena Clay-Farrace;Heike Fiegler

  3153
  Citations

• Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

  T von Zglinicki;G Saretzki;W Döcke;C Lotze

  1085
  Citations

• Feedback between p21 and reactive oxygen production is necessary for cell senescence

  João F Passos;Glyn Nelson;Chunfang Wang;Torsten Richter

  994
  Citations

• Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

  Diana Jurk;Caroline Wilson;Joao F. Passos;Fiona Oakley

  822
  Citations

• Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.

  João F Passos;Gabriele Saretzki;Gabriele Saretzki;Shaheda Ahmed;Shaheda Ahmed;Glyn Nelson

  787
  Citations

• Mitochondria are required for pro‐ageing features of the senescent phenotype

  Clara Correia-Melo;Clara Correia-Melo;Francisco D.M. Marques;Rhys Anderson;Graeme Hewitt

  660
  Citations

• Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress.

  Shaheda Ahmed;João F. Passos;Matthew J. Birket;Tina Beckmann

  543
  Citations

• Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

  S Petersen;G Saretzki;von, Zglinicki, T

  530
  Citations

• Human cell senescence as a DNA damage response

  T. von Zglinicki;G. Saretzki;J. Ladhoff;F. d’Adda di Fagagna

  512
  Citations

• DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

  João F. Passos;Gabriele Saretzki;Thomas von Zglinicki

  392
  Citations

• Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?

  G Saretzki;von, Zglinicki, T;Serra;M Lorenz

  383
  Citations

• Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells.

  Lyle Armstrong;Katarzyna Tilgner;Gabriele Saretzki;Stuart P. Atkinson

  337
  Citations

• Replicative aging, telomeres, and oxidative stress.

  Gabriele Saretzki;Thomas Von Zglinicki

  330
  Citations

• Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells.

  Gabriele Saretzki;Lyle Armstrong;Alan Leake;Majlinda Lako

  329
  Citations

• Extracellular Superoxide Dismutase Is a Major Antioxidant in Human Fibroblasts and Slows Telomere Shortening

  Violeta Serra;Thomas von Zglinicki;Mario Lorenz;Gabriele Saretzki

  326
  Citations

• Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.

  Gabriele Saretzki;Gabriele Saretzki;Theresia Walter;Stuart Atkinson;Jõao F. Passos

  301
  Citations

• MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

  Gabriele Saretzki;Michael P. Murphy;Thomas Von Zglinicki

  230
  Citations

• Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments

  G Saretzki;N Sitte;U Merkel;RE Wurm

  230
  Citations

• Accelerated Telomere Shortening in Fibroblasts After Extended Periods of Confluency

  N Sitte;G Saretzki;T von Zglinicki

  206
  Citations

• Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice.

  Satomi Miwa;Howsun Jow;Karen Baty;Amy Johnson

  204
  Citations