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Biology and Biochemistry

D-Index
52
Citations
11727
World Ranking
16558
National Ranking
1307

Overview

Lyle Armstrong is affiliated with Newcastle University in the United Kingdom and has a significant research portfolio primarily in biochemistry, genetics, molecular biology, and medicine. Their work spans several key subfields, including molecular biology, ophthalmology, cellular and molecular neuroscience, radiology, nuclear medicine, imaging, and genetics.

Their research touches on multiple specialized topics, such as retinal development and disorders, epigenetics and DNA methylation, neuroscience and neural engineering, retinal diseases and treatments, genomics and chromatin dynamics, photoreceptor and optogenetics research, and pluripotent stem cells research.

Armstrong has contributed to numerous papers, some of which include:

  • "A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells" (2021, The Ocular Surface)
  • "Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface" (2020, The Ocular Surface)
  • "Transplanted Pluripotent Stem Cell-Derived Photoreceptor Precursors Elicit Conventional and Unusual Light Responses in Mice With Advanced Retinal Degeneration" (2021, Stem Cells)
  • "Platform to study intracellular polystyrene nanoplastic pollution and clinical outcomes" (2020, Stem Cells)
  • "Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function" (2020, Stem Cells Translational Medicine)

Frequent co-authors contributing to Armstrong's work include Majlinda Lako, Joseph Collin, Birthe Dorgau, Rachel Queen, and Μαρία Γεωργίου.

Armstrong regularly publishes research in several venues with multiple contributions in each, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Stem Cells Translational Medicine
  • Stem Cells
  • The Ocular Surface
  • Frontiers in Cell and Developmental Biology

In addition to journal articles, Armstrong has authored a book titled Epigenetics, published as an eBook by Garland Science in 2020.

Best Publications

  • Ethical and Safety Issues of Stem Cell-Based Therapy.

    Volarevic;BS Markovic;M Gazdic;A Volarevic

  • The role of PI3K/AKT, MAPK/ERK and NFκβ signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis

    Lyle Armstrong;Owen Hughes;Sun Yung;Louise Hyslop

  • Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

    Katherine Amps;Peter W. Andrews;George Anyfantis;Lyle Armstrong

  • Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages.

    Louise Hyslop;Miodrag Stojkovic;Lyle Armstrong;Theresia Walter

  • Efficient Hematopoietic Differentiation of Human Embryonic Stem Cells on Stromal Cells Derived from Hematopoietic Niches

    Maria H. Ledran;Anna Krassowska;Lyle Armstrong;Ian Dimmick

  • Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells.

    Lyle Armstrong;Katarzyna Tilgner;Gabriele Saretzki;Stuart P. Atkinson

  • An Autogeneic Feeder Cell System That Efficiently Supports Growth of Undifferentiated Human Embryonic Stem Cells

    Petra Stojkovic;Majlinda Lako;Rebecca Stewart;Stefan Przyborski

  • Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells.

    Gabriele Saretzki;Lyle Armstrong;Alan Leake;Majlinda Lako

  • Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity

    Lyle Armstrong;Miodrag Stojkovic;Ian Dimmick;Sajjad Ahmad

  • Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.

    Gabriele Saretzki;Gabriele Saretzki;Theresia Walter;Stuart Atkinson;Jõao F. Passos

  • Derivation of Human Embryonic Stem Cells from Developing and Arrested Embryos

    Xin Zhang;Petra Stojkovic;Stefan Przyborski;Michael Cooke

  • Differentiation of Human Embryonic Stem Cells into Corneal Epithelial‐Like Cells by In Vitro Replication of the Corneal Epithelial Stem Cell Niche

    Sajjad Ahmad;Rebecca Stewart;Sun Yung;Sai Kolli;Sai Kolli

  • Derivation of human embryonic stem cells from day-8 blastocysts recovered after three-step in vitro culture.

    Miodrag Stojkovic;Majlinda Lako;Petra Stojkovic;Rebecca Stewart

  • Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes.

    Miodrag Stojkovic;Petra Stojkovic;Christine Leary;Vanessa Jane Hall

  • Isolation of primordial germ cells from differentiating human embryonic stem cells.

    Katarzyna Tilgner;Stuart P. Atkinson;Anna Golebiewska;Miodrag Stojković

  • Hair follicle dermal cells repopulate the mouse haematopoietic system

    Majlinda Lako;Lyle Armstrong;Paul M. Cairns;Sue Harris

  • A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

    Xin Zhang;Irina Neganova;Stefan Przyborski;Chunbo Yang

  • Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage

    L. Armstrong;L. Armstrong;G. Saretzki;H. Peters;I. Wappler

  • Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

    Adriana Buskin;Lili Zhu;Valeria Chichagova;Basudha Basu

  • Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer.

    Lyle Armstrong;Majlinda Lako;Wendy Dean;Miodrag Stojkovic

Frequent Co-Authors

Majlinda Lako
Majlinda Lako Newcastle University
Miodrag Stojkovic
Miodrag Stojkovic University of Kragujevac
Stefan Przyborski
Stefan Przyborski Durham University
Gabriele Saretzki
Gabriele Saretzki Newcastle University
Evelyne Sernagor
Evelyne Sernagor Newcastle University
Colin A. Johnson
Colin A. Johnson University of Leeds
Bernard Keavney
Bernard Keavney University of Manchester
Susan Lindsay
Susan Lindsay Newcastle University
David J. Elliott
David J. Elliott Newcastle University
Chris F. Inglehearn
Chris F. Inglehearn University of Leeds

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