World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
9691
World Ranking
13410
National Ranking
1043

Overview

John A. Kirby is affiliated with Newcastle University in the United Kingdom. Their research spans multiple disciplines within medicine and the biomedical sciences, with a focus on both clinical and molecular aspects of disease. Kirby's work has contributed to understanding pathological mechanisms and improving approaches to diagnosis and treatment in diverse areas.

Their primary fields of study include Medicine and Biochemistry, Genetics and Molecular Biology. Within these broader domains, Kirby has conducted research in specialized subfields such as Oncology, Surgery, Immunology, Molecular Biology, and Hepatology. This multidisciplinary approach supports investigation into complex disease processes and therapeutic strategies.

Key topics addressed in Kirby's research are:

  • Liver Diseases and Immunity
  • Orthopaedic implants and arthroplasty
  • Liver Disease Diagnosis and Treatment
  • Cancer Cells and Metastasis
  • Chemokine receptors and signaling
  • Immunotherapy and Immune Responses
  • Inflammatory Bowel Disease

Kirby's recent publications illustrate their diverse research interests and include:

  • "Regulation and Role of αE Integrin and Gut Homing Integrins in Migration and Retention of Intestinal Lymphocytes during Inflammatory Bowel Disease," 2021, The Journal of Immunology
  • "The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis," 2021, Hepatology
  • "MiR-126-3p Is Dynamically Regulated in Endothelial-to-Mesenchymal Transition during Fibrosis," 2021, International Journal of Molecular Sciences
  • "HER2 splice variants in breast cancer: investigating their impact on diagnosis and treatment outcomes," 2020, Oncotarget
  • "The relationship between disease activity and UDCA response criteria in primary biliary cholangitis: A cohort study," 2022, EBioMedicine

Their work has appeared in a range of academic journals, with frequent contributions to the following publication venues:

  • International Journal of Molecular Sciences
  • American Journal Of Pathology
  • Cancers
  • Orthopaedic Proceedings
  • The Journal of Immunology

Frequent collaborators in Kirby's research include Jeremy M. Palmer, Alison Tyson-Capper, Ben Barron-Millar, Christopher A Lamb, and George Mells. Collaborative efforts have contributed to advancing understanding in areas related to liver diseases, immunology, and cancer biology.

Best Publications

  • Epithelial-to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance

    Paraskevi Mallini;Thomas Lennard;John Kirby;Annette Meeson

  • Pulmonary transplantation: the role of brain death in donor lung injury.

    Vassilios S. Avlonitis;Andrew J. Fisher;John A. Kirby;John H. Dark

  • Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease.

    Karolina A Rygiel;Helen Robertson;Helen L Marshall;Marcin Pekalski

  • The hemodynamic mechanisms of lung injury and systemic inflammatory response following brain death in the transplant donor

    Vassilios S. Avlonitis;Christopher H. Wigfield;John A. Kirby;John H. Dark

  • Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis

    Helen Robertson;John A. Kirby;William W. Yip;David E.J. Jones

  • Examination of the function of RANTES, MIP-1α, and MIP-1β following interaction with heparin-like glycosaminoglycans

    Simi Ali;Adrian C.V. Palmer;Ben Banerjee;Sarah J. Fritchley

  • Randomized clinical trial of omega‐3 fatty acid‐supplemented enteral nutrition versus standard enteral nutrition in patients undergoing oesophagogastric cancer surgery

    J Sultan;S M Griffin;F Di Franco;J A Kirby

  • Chronic Renal Allograft Dysfunction: The Role of T Cell–Mediated Tubular Epithelial to Mesenchymal Cell Transition

    Helen Robertson;Simi Ali;Benjamin J McDonnell;Alastair D Burt

  • Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation

    Lee A Borthwick;Sean M Parker;Kathrine A Brougham;Gail E Johnson

  • Neutrophil chemotaxis and receptor expression in clinical septic shock

    Ahmad D. Chishti;Brian K. Shenton;John A. Kirby;Simon V. Baudouin;Simon V. Baudouin

  • Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis.

    Gaik W. Tew;Jason A. Hackney;Deena Gibbons;Christopher A. Lamb

  • Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients

    C Ward;I A Forrest;D M Murphy;G E Johnson

  • Toll-like receptor interactions: tolerance of MyD88-dependent cytokines but enhancement of MyD88-independent interferon-β production

    Andrea Broad;John A. Kirby;David E. J. Jones

  • The trouble with kidneys derived from the non heart-beating donor: a single center 10-year experience.

    J Kirby;P Griffiths;D Manas;C Snowden

  • A comparison of the antigen‐presenting capabilities of class II MHC‐expressing human lung epithelial and endothelial cells

    A C Cunningham;J G Zhang;J V Moy;S Ali

  • Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis.

    Stephen J. Yeaman;John A. Kirby;David E. J. Jones

  • Toll-like receptor (TLR) response tolerance: a key physiological "damage limitation" effect and an important potential opportunity for therapy.

    Andrea Broad;David E.J. Jones;John A. Kirby

  • Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanism.

    Marta R. Gorowiec;Lee A. Borthwick;Sean M. Parker;John A. Kirby

  • Leucocyte chemotaxis: Examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by Monocyte Chemoattractant Proteins-1, -2, -3 and -4

    Julie Wain;John Kirby;Simi Ali

  • TGF-beta expression in renal transplant biopsies: a comparative study between cyclosporin-A and tacrolimus.

    Mostafa A. S. Mohamed;Helen Robertson;Trevor A. Booth;Shlokarth Balupuri

Frequent Co-Authors

David Jones
David Jones Newcastle University
Alastair D. Burt
Alastair D. Burt Newcastle University
Paul A. Corris
Paul A. Corris Newcastle University
Chris Ward
Chris Ward Newcastle University
Margaret F. Bassendine
Margaret F. Bassendine Newcastle University
David E. Neal
David E. Neal University of Cambridge
John Kelly
John Kelly University College London
Adrian Hayday
Adrian Hayday King's College London
Stefan Schreiber
Stefan Schreiber Kiel University

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