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Genetics

D-Index
86
Citations
49558
World Ranking
1232
National Ranking
46

Overview

Aaron Isaacs is affiliated with Maastricht University in the Netherlands, focusing primarily on medicine with a particular emphasis on cardiology and cardiovascular medicine. Their research intersects several subfields including molecular biology, genetics, surgery, and immunology.

Their work covers a range of topics within cardiac health and genetics. Main topics of research include:

  • Atrial Fibrillation Management and Outcomes
  • Cardiac Arrhythmias and Treatments
  • Cardiac electrophysiology and arrhythmias
  • Genetic Associations and Epidemiology
  • Epigenetics and DNA Methylation
  • Cardiomyopathy and Myosin Studies
  • Birth, Development, and Health

Aaron Isaacs has contributed to multiple research papers in high-impact journals. Notable recent papers include:

  • Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability, 2021, Nature Communications
  • Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour, 2021, Nature Human Behaviour
  • Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction, 2020, Nature Communications
  • GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification, 2023, Nature Genetics
  • Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference, 2020, EP Europace

These publications reflect a focus on genetic epidemiology, cardiac electrophysiology, and improved clinical strategies for atrial fibrillation.

Frequent coauthors collaborating with Aaron Isaacs include:

  • Ulrich Schotten
  • Stef Zeemering
  • Michał Kawczyński
  • Sander Verheule
  • Joris Winters

The scientist's research frequently appears in several venues, with multiple publications in:

  • Heart Rhythm
  • EP Europace
  • UNC Libraries
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)

The combination of research fields, topics, frequent collaborations, and publication venues underscores a multidisciplinary approach to cardiovascular medicine with a strong integration of genetic and molecular biology perspectives.

Best Publications

  • Biological, clinical and population relevance of 95 loci for blood lipids

    Tanya M. Teslovich;Kiran Musunuru;Albert V. Smith;Andrew C. Edmondson

  • Discovery and refinement of loci associated with lipid levels

    Cristen J. Willer;Ellen M. Schmidt;Sebanti Sengupta;Gina M. Peloso;Gina M. Peloso;Gina M. Peloso

  • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

    Georg B. Ehret;Georg B. Ehret;Georg B. Ehret;Patricia B. Munroe;Kenneth M. Rice;Murielle Bochud

  • Defining the role of common variation in the genomic and biological architecture of adult human height

    Andrew R. Wood;Tonu Esko;Jian Yang;Sailaja Vedantam

  • GenABEL: an R library for genome-wide association analysis

    Y. S. Aulchenko;S. Ripke;A. Isaacs;C. M. Van Duijn

  • Genetic studies of body mass index yield new insights for obesity biology

    Adam E. Locke;Bratati Kahali;Sonja I. Berndt;Anne E. Justice

  • Common variants associated with plasma triglycerides and risk for coronary artery disease

    Ron Do;Cristen J. Willer;Ellen M. Schmidt;Sebanti Sengupta

  • Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

    Yurii S Aulchenko;Samuli Ripatti;Ida Lindqvist;Dorret Boomsma

  • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

    Anna Köttgen;Anna Köttgen;Eva Albrecht;Alexander Teumer;Veronique Vitart

  • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

    Robert A Scott;Vasiliki Lagou;Ryan P Welch;Eleanor Wheeler

  • New loci associated with kidney function and chronic kidney disease

    Anna Köttgen;Anna Köttgen;Cristian Pattaro;Carsten A. Böger;Christian Fuchsberger

  • Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

    Simone Wahl;Alexander Drong;Benjamin Lehne;Marie Loh;Marie Loh;Marie Loh

  • Whole-genome sequence variation, population structure and demographic history of the Dutch population

    Laurent C. Francioli;Androniki Menelaou;Sara L. Pulit;Freerk van Dijk

  • Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

    Z Dastani;Hivert M-F.;Hivert M-F.;N Timpson;Perry Jrb.;Perry Jrb.

  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

    Cristian Pattaro;Alexander Teumer;Mathias Gorski;Audrey Y. Chu

  • Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

    Linda Broer;Veryan Codd;Veryan Codd;Dale R Nyholt;Joris Deelen

  • FTO genotype is associated with phenotypic variability of body mass index

    Jian Yang;Jian Yang;Ruth J F Loos;Ruth J F Loos;Joseph E. Powell;Joseph E. Powell;Sarah E. Medland

  • Disease variants alter transcription factor levels and methylation of their binding sites.

    Marc Jan Bonder;René Luijk;Daria V Zhernakova;Matthijs Moed

  • The UK10K project identifies rare variants in health and disease

    Klaudia Walter;Josine L. Min;Jie Huang;Lucy Crooks

  • Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

    Beben Benyamin;Tonu Esko;Janina S. Ried;Aparna Radhakrishnan

Frequent Co-Authors

Albert Hofman
Albert Hofman Harvard University
André G. Uitterlinden
André G. Uitterlinden Erasmus University Rotterdam
Bruce M. Psaty
Bruce M. Psaty University of Washington
Igor Rudan
Igor Rudan University of Edinburgh
Albert V. Smith
Albert V. Smith University of Michigan–Ann Arbor
Vilmundur Gudnason
Vilmundur Gudnason University of Iceland
James F. Wilson
James F. Wilson University of Edinburgh
Caroline Hayward
Caroline Hayward University of Edinburgh
Olli T. Raitakari
Olli T. Raitakari Turku University Hospital
Tim D. Spector
Tim D. Spector King's College London

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