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Genetics

D-Index
72
Citations
49417
World Ranking
2080
National Ranking
74

Overview

Harm-Jan Westra is affiliated with the University Medical Center Groningen in the Netherlands and has a research focus rooted in the fields of Biochemistry, Genetics, and Molecular Biology. Their work spans multiple subfields including Molecular Biology, Genetics, Cancer Research, Immunology, and Neurology.

The research topics that Harm-Jan Westra has contributed to cover a range of areas such as Genetic Associations and Epidemiology, Single-cell and Spatial Transcriptomics, Cancer Genomics and Diagnostics, Bioinformatics and Genomic Networks, Epigenetics and DNA Methylation, Gut Microbiota and Health, and RNA Research and Splicing.

They have published extensively, with significant appearances in publication venues including the University of Groningen research database (University of Groningen / Centre for Information Technology), bioRxiv (Cold Spring Harbor Laboratory), Nature Genetics, Nature Communications, and UNC Libraries.

Recent papers authored or co-authored by Harm-Jan Westra include:

  • Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression (2021, Nature Genetics)
  • Large-scale association analyses identify host factors influencing human gut microbiome composition (2021, Nature Genetics)
  • Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals (2020, Nature Metabolism)
  • Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology (2021, Nature Genetics)
  • Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases (2023, Nature Genetics)

Harm-Jan Westra frequently collaborates with several scientists, including:

  • Lude Franke
  • Annique Claringbould
  • Patrick Deelen
  • Dorret I. Boomsma
  • Roy Oelen

Best Publications

  • Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

    James J. Lee;Robbee Wedow;Aysu Okbay;Edward Kong

  • Genetics of rheumatoid arthritis contributes to biology and drug discovery

    Yukinori Okada;Yukinori Okada;Di Wu;Di Wu;Di Wu;Gosia Trynka;Gosia Trynka;Towfique Raj;Towfique Raj

  • Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

    J Z Liu;S van Sommeren;H Huang;S C Ng

  • Defining the role of common variation in the genomic and biological architecture of adult human height

    Andrew R. Wood;Tonu Esko;Jian Yang;Sailaja Vedantam

  • Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

    Urmo Võsa;Annique Claringbould;Annique Claringbould;Harm-Jan Westra;Marc Jan Bonder

  • Systematic identification of trans eQTLs as putative drivers of known disease associations

    Harm-Jan Westra;Marjolein J Peters;Tõnu Esko;Hanieh Yaghootkar

  • Large-scale association analyses identify host factors influencing human gut microbiome composition

    Alexander Kurilshikov;Carolina Medina-Gomez;Rodrigo Bacigalupe;Djawad Radjabzadeh

  • Genetic studies of body mass index yield new insights for obesity biology

    Adam E. Locke;Bratati Kahali;Sonja I. Berndt;Anne E. Justice

  • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Carl A. Anderson;Gabrielle Boucher;Charlie W. Lees;Andre Franke

  • Genome-wide association study identifies 74 loci associated with educational attainment

    Aysu Okbay;Jonathan P. Beauchamp;Mark Alan Fontana;James J. Lee

  • Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

    Aysu Okbay;Bart M L Baselmans;Jan-Emmanuel De Neve;Patrick Turley

  • GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

    Cornelius A. Rietveld;Sarah E. Medland;Jaime Lane Derringer;Jian Yang

  • Biological interpretation of genome-wide association studies using predicted gene functions

    Tune H Pers;Juha M Karjalainen;Yingleong Chan;Harm-Jan Westra

  • Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

    Richard Karlsson Linnér;Richard Karlsson Linnér;Pietro Biroli;Edward Kong;S. Fleur W. Meddens;S. Fleur W. Meddens

  • Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

    David Ellinghaus;Luke Jostins;Sarah L. Spain;Adrian Cortes

  • High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

    Steve Eyre;John Bowes;John Bowes;Dorothée Diogo;Dorothée Diogo;Annette Lee

  • The transcriptional landscape of age in human peripheral blood

    Marjolein J. Peters;Roby Joehanes;Luke C. Pilling;Claudia Schurmann;Claudia Schurmann

  • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

    Thomas W. Winkler;Anne E. Justice;Mariaelisa Graff;Llilda Barata

  • Genome-wide association study identifies 74 loci associated with educational attainment

    Aysu Okbay;Jonathan P. Beauchamp;Mark Alan Fontana;James J. Lee

  • Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

    Aysu Okbay;Bart M. L. Baselmans;Jan-Emmanuel De Neve;Patrick Turley

Frequent Co-Authors

Lude Franke
Lude Franke University Medical Center Groningen
Tonu Esko
Tonu Esko University of Tartu
Andres Metspalu
Andres Metspalu University of Tartu
Olli T. Raitakari
Olli T. Raitakari Turku University Hospital
Markus Perola
Markus Perola Finnish Institute for Health and Welfare
Jian Yang
Jian Yang University of Birmingham
Grant W. Montgomery
Grant W. Montgomery University of Queensland
Dorret I. Boomsma
Dorret I. Boomsma Vrije Universiteit Amsterdam
Albert Hofman
Albert Hofman Harvard University
Albert V. Smith
Albert V. Smith University of Michigan–Ann Arbor

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