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Chemistry

D-Index
63
Citations
16294
World Ranking
8327
National Ranking
473

Research.com Recognitions

  • 2009 - Fellow of the Royal Society, United Kingdom
  • 1991 - Interdisciplinary Prize, Royal Society of Chemistry (UK)

Overview

Malcolm F. G. Stevens is affiliated with the University of Nottingham in the United Kingdom. Their research primarily focuses on materials science with a significant concentration in materials chemistry.

The scientist has contributed notably to the study of crystallization and solubility, particularly using X-ray diffraction techniques in crystallography. Their work also interfaces with biomedical fields including glioma diagnosis and treatment, cancer therapeutics and mechanisms, and brain metastases management. Additionally, they have contributed research related to advanced biosensing and bioanalysis techniques as well as RNA interference and gene delivery.

Key recent publications include:

  • Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage, 2020, ACS Applied Materials & Interfaces
  • Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue, 2021, ACS Applied Materials & Interfaces
  • Discovery of new imidazotetrazinones with potential to overcome tumor resistance, 2023, European Journal of Medicinal Chemistry
  • Antitumour imidazotetrazines: past, present... and future?, 2023, RSC Chemical Biology
  • Modulation of the acidity of the 8-carboxamide group in the temozolomide family of antitumor imidazo[5,1-d][1,2,3,5]tetrazines, 2020, ARKIVOC

Frequent co-authors in their research include:

  • Tracey D. Bradshaw
  • Helen S. Summers
  • Christopher J. Moody
  • Magdalena B. Foreiter
  • William Lewis

Their work has appeared predominantly in the following publication venues:

  • The Cambridge Structural Database
  • ACS Applied Materials & Interfaces
  • European Journal of Medicinal Chemistry
  • RSC Chemical Biology
  • ARKIVOC

Recognition for their scientific contributions includes the Fellow of the Royal Society, United Kingdom, awarded in 2009, and the Interdisciplinary Prize from the Royal Society of Chemistry (UK) received in 1991.

Best Publications

  • Temozolomide: Mechanisms of Action, Repair and Resistance

    Jihong Zhang;Malcolm F.G. Stevens;Tracey D. Bradshaw

  • Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

    E.S. Newlands;M.F.G. Stevens;S.R. Wedge;R.T. Wheelhouse

  • Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines.

    Catriona G. Mortimer;Geoffrey Wells;Jean-Philippe Crochard;Erica L. Stone

  • Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs.

    Ian Hutchinson;Sharon A. Jennings;B. Rao Vishnuvajjala;and Andrew D. Westwell

  • NMR and Molecular Modeling Investigation of the Mechanism of Activation of the Antitumor Drug Temozolomide and Its Interaction with DNA

    Brian J. Denny;Richard T. Wheelhouse;Malcolm F. G. Stevens;Lincoln L. H. Tsang

  • Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo.

    Dong-Fang Shi;Tracey D. Bradshaw;Samantha Wrigley;Carol J. McCall

  • Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles.

    Ian Hutchinson;Mei-Sze Chua;Helen L. Browne;Valentina Trapani

  • Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648).

    Stefania Aiello;Geoffrey Wells;Erica L Stone;Hachemi Kadri

  • Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine

    Malcolm F. G. Stevens;John A. Hickman;Simon P. Langdon;David Chubb

  • Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours.

    S.M. O'Reilly;E.S. Newlands;M. Brampton;M.G. Glaser

  • Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

    N M Bleehen;E S Newlands;Siow Ming Lee;Nick Thatcher

  • Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.

    Sharon M. Gowan;Robert Heald;Malcolm F. G. Stevens;Lloyd R. Kelland

  • Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one , a novel broad-spectrum antitumor agent.

    Malcolm F. G. Stevens;John A. Hickman;Robert Stone;Neil W. Gibson

  • Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.

    Angela Rizzo;Erica Salvati;Manuela Porru;Carmen D’Angelo

  • Drug Recognition and Stabilisation of the Parallel-stranded DNA Quadruplex d(TTAGGGT)4 Containing the Human Telomeric Repeat

    Evripidis Gavathiotis;Robert A. Heald;Malcolm F.G. Stevens;Mark S. Searle

  • Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration.

    Carlo Leonetti;Sarah Amodei;Carmen D'Angelo;Angela Rizzo

  • Antitumour benzothiazoles. Part 20: 3'-cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analogues.

    Ian Hutchinson;Tracey D Bradshaw;Charles S Matthews;Malcolm F.G Stevens

  • Semisynthesis and in vitro anticancer activities of andrographolide analogues.

    Srinivasa Rao Jada;Genevieve Suseno Subur;Charlie Matthews;Ahmad Sazali Hamzah

  • Antitumor Benzothiazoles. 7. Synthesis of 2-(4-Acylaminophenyl)benzothiazoles and Investigations into the Role of Acetylation in the Antitumor Activities of the Parent Amines

    † Mei-Sze Chua;† Dong-Fang Shi;Samantha Wrigley;Tracey D. Bradshaw

  • Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.

    A. S. Clark;B. Deans;M. F. G. Stevens;M. J. Tisdale

  • Antitumor Polycyclic Acridines. 8.1 Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium Salts

    Robert A. Heald;Chetna Modi;Jenny C. Cookson;Ian Hutchinson

  • Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.

    Mei-Sze Chua;Eiji Kashiyama;Tracey D. Bradshaw;Sherman F. Stinson

Frequent Co-Authors

Charles A. Laughton
Charles A. Laughton University of Nottingham
Maurizio D'Incalci
Maurizio D'Incalci Humanitas University
Simon P. Langdon
Simon P. Langdon University of Edinburgh
Gabriella Zupi
Gabriella Zupi École Normale Supérieure de Lyon
Christopher J. Moody
Christopher J. Moody University of Nottingham
John A. Hickman
John A. Hickman University of Manchester
Mark S. Searle
Mark S. Searle University of Nottingham
Eric Gilson
Eric Gilson Université Côte d'Azur
William Lewis
William Lewis University of Sydney
Peter A. Lambert
Peter A. Lambert Aston University

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