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Chemistry

D-Index
45
Citations
7054
World Ranking
16492
National Ranking
631

Overview

Antonio Randazzo is affiliated with the University of Naples Federico II in Italy and has contributed extensively to the field of Biochemistry, Genetics, and Molecular Biology, with a predominant focus on Molecular Biology. Their work encompasses a total of 98 publications in this main field, with 89 specifically in Molecular Biology, alongside contributions to Organic Chemistry, Ecology, Cancer Research, and Epidemiology.

The researcher's publications cover a range of topics, including DNA and Nucleic Acid Chemistry, Advanced Biosensing and Bioanalysis Techniques, RNA Interference and Gene Delivery, RNA and Protein Synthesis Mechanisms, Bacteriophages and Microbial Interactions, Virus-Based Gene Therapy Research, and RNA Research and Splicing. A significant portion of Antonio Randazzo's research output surrounds the chemistry of nucleic acids and molecular methods related to biosensing and gene delivery systems.

Frequent publication venues for this scientist include:

  • International Journal of Molecular Sciences
  • Journal of Medicinal Chemistry
  • Angewandte Chemie International Edition
  • Physical Chemistry Chemical Physics
  • International Journal of Biological Macromolecules

Among the recent notable papers authored by Antonio Randazzo are:

  • "Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells," 2020, published in Journal of Medicinal Chemistry
  • "Effects of Sequence and Base Composition on the CD and TDS Profiles of i-DNA," 2021, published in Angewandte Chemie International Edition
  • "Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics," 2020, published in Scientific Reports
  • "Conformational plasticity of DNA secondary structures: probing the conversion between i-motif and hairpin species by circular dichroism and ultraviolet resonance Raman spectroscopies," 2022, published in Physical Chemistry Chemical Physics
  • "G-quadruplexes in cancer-related gene promoters: from identification to therapeutic targeting," 2023, published in Expert Opinion on Therapeutic Patents

Antonio Randazzo collaborates regularly with a number of co-authors, including:

  • Jussara Amato
  • Bruno Pagano
  • Nunzia Iaccarino
  • Anna Di Porzio
  • Simona Marzano

The scientist's research contributions largely focus on structures and dynamics of nucleic acids, including G-quadruplexes and i-DNA, with multiple studies examining their implications for genome stability and cancer. This work often integrates advanced spectroscopy and computational methods to explore molecular conformations and interactions.

Best Publications

  • Topological Characterization of Nucleic Acid G‐Quadruplexes by UV Absorption and Circular Dichroism

    Andreas Ioannis Karsisiotis;Nason Ma'ani Hessari;Ettore Novellino;Gian Piero Spada

  • A non-empirical chromophoric interpretation of CD spectra of DNA G-quadruplex structures

    Stefano Masiero;Roberta Trotta;Silvia Pieraccini;Stefano De Tito

  • High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity

    Irene Russo Krauss;Antonello Merlino;Antonio Randazzo;Ettore Novellino

  • Circular dichroism of quadruplex structures.

    Antonio Randazzo;Gian Piero Spada;Mateus Webba da Silva

  • Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4

    Luigi Martino;Ada Virno;Bruno Pagano;Antonella Virgilio

  • Thrombin–aptamer recognition: a revealed ambiguity

    Irene Russo Krauss;Antonello Merlino;Concetta Giancola;Antonio Randazzo

  • Stability and binding properties of a modified thrombin binding aptamer.

    Bruno Pagano;Luigi Martino;Antonio Randazzo;Concetta Giancola

  • The G‐Triplex DNA

    Vittorio Limongelli;Stefano De Tito;Linda Cerofolini;Marco Fragai

  • Halipeptins A and B: two novel potent anti-inflammatory cyclic depsipeptides from the Vanuatu marine sponge Haliclona species.

    Antonio Randazzo;Giuseppe Bifulco;Clelia Giannini;Mariarosaria Bucci

  • Effects of petrosaspongiolide M, a novel phospholipase A2 inhibitor, on acute and chronic inflammation.

    Garcia-Pastor P;Randazzo A;Gomez-Paloma L;Alcaraz Mj

  • Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.

    Sandro Cosconati;Luciana Marinelli;Roberta Trotta;Ada Virno

  • A new modified thrombin binding aptamer containing a 5′–5′ inversion of polarity site

    Luigi Martino;Ada Virno;Antonio Randazzo;Antonella Virgilio

  • Petrosaspongiolides M-R: new potent and selective phospholipase A2 inhibitors from the New Caledonian marine sponge Petrosaspongia nigra

    Antonio Randazzo;Cécile Debitus;Luigi Minale;P. García Pastor

  • Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders.

    Sandro Cosconati;Luciana Marinelli;Roberta Trotta;Ada Virno

  • Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection.

    Angela Casillo;Ermenegilda Parrilli;Filomena Sannino;Daniel E. Mitchell

  • G-triplex structure and formation propensity

    Linda Cerofolini;Jussara Amato;Andrea Giachetti;Vittorio Limongelli

  • Stability and structure of telomeric DNA sequences forming quadruplexes containing four G-tetrads with different topological arrangements

    Luigi Petraccone;Eva Erra;Veronica Esposito;Antonio Randazzo

  • Effects of an 8-bromodeoxyguanosine incorporation on the parallel quadruplex structure [d(TGGGT)]4

    Veronica Esposito;Antonio Randazzo;Gennaro Piccialli;Luigi Petraccone

  • A unique capsular polysaccharide structure from the psychrophilic marine bacterium Colwellia psychrerythraea 34H that mimics antifreeze (glyco)proteins.

    Sara Carillo;Angela Casillo;Giuseppina Pieretti;Ermenegilda Parrilli

  • AXINELLINS A AND B : NEW PROLINE-CONTAINING ANTIPROLIFERATIVE CYCLOPEPTIDES FROM THE VANUATU SPONGE AXINELLA CARTERI

    Antonio Randazzo;Fabrizio Dal Piaz;Stefania Orrù;Cécile Debitus

  • Common G-Quadruplex Binding Agents Found to Interact With i-Motif-Forming DNA: Unexpected Multi-Target-Directed Compounds

    Alessia Pagano;Nunzia Iaccarino;Mahmoud A. S. Abdelhamid;Diego Brancaccio

Frequent Co-Authors

Ettore Novellino
Ettore Novellino University of Naples Federico II
Cécile Debitus
Cécile Debitus University of Western Brittany
Claudio Luchinat
Claudio Luchinat University of Florence
Giovanni Capranico
Giovanni Capranico University of Bologna
Giuseppe Bifulco
Giuseppe Bifulco University of Salerno
Piero Pucci
Piero Pucci University of Naples Federico II
Stephen Neidle
Stephen Neidle University College London
Gian Piero Spada
Gian Piero Spada University of Bologna
Gennaro Marino
Gennaro Marino University of Naples Federico II

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