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Biology and Biochemistry

D-Index
48
Citations
7719
World Ranking
18446
National Ranking
7531

Overview

Richard Milner is affiliated with the San Diego Biomedical Research Institute in the United States and has a research focus predominantly within neuroscience, medicine, and biochemistry, genetics, and molecular biology. Their academic output spans 41 publications in neuroscience, 24 in medicine, and 17 in biochemistry, genetics, and molecular biology.

The main subfields of study for Milner include neurology, immunology and allergy, molecular biology, genetics, and epidemiology. Their research covers a range of interconnected topics such as barrier structure and function studies, neuroinflammation and neurodegeneration mechanisms, neurological disease mechanisms and treatments, cell adhesion molecules research, high altitude and hypoxia, acute ischemic stroke management, and caveolin-1 related cellular processes.

Milner's frequently published venues reflect a focus on the neurovascular and neurological research community. These include:

  • Fluids and Barriers of the CNS
  • Glia
  • Aging
  • Acta Neuropathologica Communications
  • Neural Regeneration Research

Coauthorship collaboration is extensive with researchers such as Sebok K. Halder, Arjun Sapkota, Cong Wang, Heng Huang, and Kegui Zhou, indicating a network in neurovascular biology and immunology. Sebok K. Halder is noted as a particularly frequent collaborator with 24 joint publications.

The following recent papers exemplify Milner's research contributions, showing an emphasis on blood-brain barrier dynamics, hypoxia, and neuroimmune interactions:

  • Mild hypoxia triggers transient blood-brain barrier disruption: a fundamental protective role for microglia (2020) published in Acta Neuropathologica Communications
  • The impact of genetic manipulation of laminin and integrins at the blood-brain barrier (2022) published in Fluids and Barriers of the CNS
  • Hypoxia in multiple sclerosis; is it the chicken or the egg? (2020) published in Brain
  • Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation (2020) published in Frontiers in Neuroscience
  • The importance of laminin at the blood-brain barrier (2023) published in Neural Regeneration Research

Best Publications

  • The integrin family of cell adhesion molecules has multiple functions within the CNS.

    Richard Milner;Iain L. Campbell

  • Integrin–Matrix Interactions in the Cerebral Microvasculature

    Gregory J. del Zoppo;Richard Milner

  • Microglial activation and matrix protease generation during focal cerebral ischemia.

    Gregory J. del Zoppo;Richard Milner;Takuma Mabuchi;Stephanie Hung

  • A developmental analysis of oligodendroglial integrins in primary cells: changes in alpha v-associated beta subunits during differentiation.

    R. Milner;C. Ffrench-Constant

  • A Role in Migration for the αvβ1 Integrin Expressed on Oligodendrocyte Precursors

    Richard Milner;Gwynneth Edwards;Charles Streuli;Charles ffrench-Constant;Charles ffrench-Constant

  • The extracellular matrix and cytokines regulate microglial integrin expression and activation.

    Richard Milner;Iain L. Campbell

  • Division of Labor of Schwann Cell Integrins during Migration on Peripheral Nerve Extracellular Matrix Ligands

    Richard Milner;Martin Wilby;Stephen Nishimura;Kevin Boylen

  • Microglia are the major source of TNF-α and TGF-β1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin.

    Jennifer V. Welser-Alves;Richard Milner

  • Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration

    Richard Milner;Helen J. Anderson;Rebecca F. Rippon;Jennifer S. McKay

  • Fibronectin promotes brain capillary endothelial cell survival and proliferation through alpha5beta1 and alphavbeta3 integrins via MAP kinase signalling.

    Jan Wang;Richard Milner

  • Cytokines regulate microglial adhesion to laminin and astrocyte extracellular matrix via protein kinase C-dependent activation of the α6β1 integrin

    Richard Milner;Iain L. Campbell

  • Interferon-Independent, Human Immunodeficiency Virus Type 1 gp120-Mediated Induction of CXCL10/IP-10 Gene Expression by Astrocytes In Vivo and In Vitro

    Valérie C. Asensio;Joachim Maier;Richard Milner;Kaan Boztug

  • Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by β(1)-integrins.

    Takashi Osada;Yu Huan Gu;Masato Kanazawa;Yoshiaki Tsubota

  • Developmental Regulation of β1 Integrins during Angiogenesis in the Central Nervous System

    Richard Milner;Iain L. Campbell

  • Fibronectin- and Vitronectin-Induced Microglial Activation and Matrix Metalloproteinase-9 Expression Is Mediated by Integrins α5β1 and αvβ5

    Richard Milner;Stephen J. Crocker;Stephanie Hung;Xiaoyun Wang

  • Responses of Endothelial Cell and Astrocyte Matrix-Integrin Receptors to Ischemia Mimic Those Observed in the Neurovascular Unit

    Richard Milner;Stephanie Hung;Xiaoyun Wang;Greta I. Berg

  • Use of Gel Zymography to Examine Matrix Metalloproteinase (Gelatinase) Expression in Brain Tissue or in Primary Glial Cultures

    Harald Frankowski;Yu Huan Gu;Ji Hoe Heo;Richard Milner

  • Astrocytic Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Promotes Oligodendrocyte Differentiation and Enhances CNS Myelination

    C. S. Moore;R. Milner;A. Nishiyama;R. F. Frausto

  • Increased expression of fibronectin and the α5β1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxia

    Richard Milner;Stephanie Hung;Bernadette Erokwu;Paula Dore-Duffy

  • Differentiation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter.

    R. J. M. Franklin;S. A. Bayley;R. Milner;C. Ffrench-Constant

Frequent Co-Authors

Charles ffrench-Constant
Charles ffrench-Constant University of Edinburgh
Iain L. Campbell
Iain L. Campbell University of Sydney
Charles H. Streuli
Charles H. Streuli University of Manchester
James A. Koziol
James A. Koziol Scripps Research Institute
J. Lindsay Whitton
J. Lindsay Whitton Scripps Research Institute
José A. Fernández
José A. Fernández Scripps Research Institute
M. Laura Feltri
M. Laura Feltri University at Buffalo, State University of New York
James W. Fawcett
James W. Fawcett University of Cambridge
Joseph C. LaManna
Joseph C. LaManna Case Western Reserve University

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