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D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
15548
World Ranking
12378
National Ranking
955

Overview

Simon T. Barry is affiliated with AstraZeneca in the United Kingdom and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields, including Molecular Biology, Oncology, Immunology, Pulmonary and Respiratory Medicine, and Cancer Research.

The scientist's research topics encompass a range of areas within cancer biology and immunology. These include:

  • Immune cells in cancer
  • PI3K/AKT/mTOR signaling in cancer
  • Cancer Immunotherapy and Biomarkers
  • Cancer Genomics and Diagnostics
  • Pancreatic and Hepatic Oncology Research
  • Immune Cell Function and Interaction
  • Cancer Cells and Metastasis

The publication venues frequently associated with Simon T. Barry's work reflect a focus on cancer and molecular biology research. Among these venues are:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Analytical Chemistry
  • npj Breast Cancer

Simon T. Barry has collaborated extensively with a number of researchers in their field. Frequent co-authors include:

  • Richard J. A. Goodwin
  • Owen J. Sansom
  • Grégory Hamm
  • Andrew D. Campbell
  • Josephine Bunch

Selected recent papers authored or co-authored by Simon T. Barry include:

  • The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer, 2021, Nature Genetics
  • Therapeutic targeting of tumour myeloid cells, 2023, Nature reviews. Cancer
  • CXCR2 inhibition enables NASH-HCC immunotherapy, 2022, Gut
  • Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer, 2020, Gastroenterology
  • MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects, 2020, Nature Immunology

Best Publications

  • Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

    Uma Prabhakar;Hiroshi Maeda;Rakesh K. Jain;Eva M. Sevick-Muraca

  • Challenges and strategies in anti-cancer nanomedicine development: An industry perspective ☆

    Jennifer I. Hare;Twan Lammers;Marianne B. Ashford;Sanyogitta Puri

  • AZD2171: A Highly Potent, Orally Bioavailable, Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor for the Treatment of Cancer

    Stephen R. Wedge;Jane Kendrew;Laurent F. Hennequin;Paula J. Valentine

  • CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

    Colin W. Steele;Saadia A. Karim;Joshua D.G. Leach;Peter Bailey

  • PDGF-regulated rab4-dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading

    Marnie Roberts;Simon Barry;Alison Woods;Peter van der Sluijs

  • Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.

    Rene Jackstadt;Sander R. van Hooff;Joshua D. Leach;Xabier Cortes-Lavaud

  • IL-23 secreted by myeloid cells drives castration-resistant prostate cancer

    Arianna Calcinotto;Clarissa Spataro;Elena Zagato;Diletta Di Mitri

  • WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

    Luke Boulter;Rachel V. Guest;Timothy J. Kendall;David H. Wilson

  • Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ.

    Sarit Schwartz;John Wongvipat;Cath B. Trigwell;Urs Hancox

  • The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-delta to focal adhesions

    Simon T. Barry;David R. Critchley

  • Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

    Susan Ashton;Young Ho Song;Jim Nolan;Elaine Cadogan

  • Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sites.

    John Weekes;Simon T. Barry;David R. Critchley

  • TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

    Thomas G. Bird;Thomas G. Bird;Miryam Müller;Luke Boulter;David F. Vincent

  • CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype.

    Juliana B. Candido;Jennifer P. Morton;Peter Bailey;Andrew D. Campbell

  • Requirement for Rho in Integrin Signalling

    Simon T. Barry;Helen M. Flinn;Martin J. Humphries;David R. Critchley

  • The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3.

    Steven B Ludbrook;Simon T Barry;Chris J Delves;Carmel M T Horgan

  • ARF1 Mediates Paxillin Recruitment to Focal Adhesions and Potentiates Rho-stimulated Stress Fiber Formation in Intact and Permeabilized Swiss 3T3 Fibroblasts

    J.C. Norman;D. Jones;S.T. Barry;M.R. Holt

  • Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

    Diletta Di Mitri;Michela Mirenda;Jelena Vasilevska;Arianna Calcinotto

  • Analysis of the α4β1 Integrin–Osteopontin Interaction

    Simon T. Barry;Steven B. Ludbrook;Elaine Murrison;Carmel M.T. Horgan

  • The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.

    Arafath K. Najumudeen;Fatih Ceteci;Sigrid K. Fey;Gregory Hamm

Frequent Co-Authors

Owen J. Sansom
Owen J. Sansom University of Glasgow
Andrew V. Biankin
Andrew V. Biankin University of Glasgow
Jennifer P. Morton
Jennifer P. Morton University of Glasgow
Colin Nixon
Colin Nixon University of Glasgow
David R. Critchley
David R. Critchley University of Leicester
Marie Cumberbatch
Marie Cumberbatch AstraZeneca (United Kingdom)
Zoltan Takats
Zoltan Takats Imperial College London
Jim C. Norman
Jim C. Norman University of Glasgow
Frances R. Balkwill
Frances R. Balkwill Queen Mary University of London
Alan Ashworth
Alan Ashworth University of California, San Francisco

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